A metal-organic framework ZIF-8@Fe3O4 composite was synthesized for the extraction of endocrine disrupting chemicals(EDCs) in water samples by magnetic solid phase extraction(MSPE).Effects of ZIF-8 growth cycles,extraction time,ionic strength,pH,desorption solvent and desorption time on MSPE were investigated.The developed MSPE combined with high performance liquid chromatography was successfully applied in the detection of 4 endocrine disrupting chemicals(EDCs),i.e.bisphenol A,nonyl phenol,octyl phenol and estrone in water samples.Under the optimized conditions,there existed linear relationships for the 4 analytes in the range of 1.0-1 000 μg/L,with the detection limits(S/N=3) of 0.42-0.81 μg/L and the enhancement factors of 61-144.The relative standard deviations(RSDs) for inter-day(n=6) and intra day(n=3) were 2.1%-4.3% and 3.5%-5.8%,respectively.