There are two kinds of redox reactions occurring in electrospray ionization mass spectrometry,ie.electrochemistry and corona discharge induced redox reactions.On one hand,the two kinds of redox reactions will complicate the mass spectra,and decrease the sensitivity for analyte detection.On the other hand,the reactions could be used to develop new ionization sources,improve the ionization efficiency for hardly ionized species and study the protein interaction.The research progress of electrochemistry and corona discharge induced redox reactions at home and abroad was introduced in this review,including their advantages and disadvantages,as well as the methods used to control the two redox reactions.Finally,the methods used to distinguish the two kinds of oxidation reaction were summarized.