A method of high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS）was presented for the determination of five halogenated methyl sulfonic acids（HMSAs）in sludge from municipal sewage treatment plant.Through investigation on extract solvent，extraction method and times，the optimum conditions were obtained as follows:the mixture of methanol and water（1∶1，by volume）was selected as extraction solvent，samples were continually oscillated at 350 r/min for 1 hour，and extracted once.Under the optimized conditions，the extraction efficiencies were（484±28）%，（683±09）%，（810±48）%，（380±11）% and（991±12）% for chloromethanesulfonic acid，dichloromethanesulfonic acid，trichloromethanesulfonic acid，bromomethanesulfonic acid and trifluoromethanesulfonic acid，respectively.The calibration curves for the analytes were linear in the range of 005-50 μg·kg-1 with their correlation coefficients（r）larger than 0991.The limits of detection（LOD）of the method ranged from 0003 to 0018 μg·kg-1 for HMSAs，and the limits of quantitation（LOQ）were in the range of 0010-0059 μg·kg-1.The spiked recoveries for HMSAs in sewage sludge were in the range of 738%-101% with relative standard deviations of 23%-125%.