An automatic solid sampling system for time of flight mass spectrometer has been developed in this paper.It is based on a conventional AB Sciex Triple TOF 4600 time of flight mass spectrometer(TOF) with configuration of mobile platform，sampling rod,industrial camera,LED light source,industrial display screen and other components.Solid organic samples could be tested and analyzed directly without any complex pre processing.References are provided for upgrading and renovating of relevant laboratories according to this system.Insoluble unknown organic compounds in pharmaceutical,food,environmental and other kinds of samples could be analyzed quickly,and rapid screening for targets could be achieved by this system.The operator may observe the status of the sample at the inlet of mass spectrometry in real time by screen without the help of extra light source.Automatic test for men machine separation has been realized with software to control.