A method of high performance liquid chromatography(HPLC) with deep eutectic solvent extraction was established for the rapid determination of organic synthetic pigments in drinks and compound wines.The deep eutectic solvent was a new hydrophobic eutectic material synthesized with tetrabutyl ammonium chloride and octanoic acid.Samples were dissolved with water,then extracted with 200 μL deep eutectic solvent,finally detected by HPLC-diode array detector(DAD) and quantified by external standard method.Results indicated that there were good linear relationships for 11 kinds of organic synthetic pigments in respective mass concentration ranges with their correlation coefficients(r2) all greater than 0.996.The limits of detection(LOD)and the limits of quantitation(LOQ) were in the ranges of 0.03-0.31 mg/kg and 0.08-1.02 mg/kg,respectively.The recoveries ranged from 92.6% to 103% with relative standard deviations(RSD)of 0.98%-4.3%.The method is rapid,simple and accurate,and is suitable for the determination of organic synthetic pigments in drinks and compound wines.