Determination of Seven Dimethylcyclosiloxanes in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry

LI Si-yuan; CHEN An-li; ZHAO Si-wen; YAN Xiao-hong; DING Yi

doi:10.19969/j.fxcsxb.23091802

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Determination of Seven Dimethylcyclosiloxanes in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry

Scientific Papers | 更新时间：2023-12-25

- Determination of Seven Dimethylcyclosiloxanes in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry
- Journal of Instrumental Analysis Vol. 42, Issue 12, Pages: 1607-1614(2023)
- 作者机构：
  
  广州市药品检验所，广东广州 510160
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.23091802
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李思源,陈安丽,赵思雯等.气相色谱-串联质谱法测定化妆品中7种二甲基环硅氧烷[J].分析测试学报,2023,42(12):1607-1614.

LI Si-yuan,CHEN An-li,ZHAO Si-wen,et al.Determination of Seven Dimethylcyclosiloxanes in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2023,42(12):1607-1614.
李思源,陈安丽,赵思雯等.气相色谱-串联质谱法测定化妆品中7种二甲基环硅氧烷[J].分析测试学报,2023,42(12):1607-1614. DOI： 10.19969/j.fxcsxb.23091802.

LI Si-yuan,CHEN An-li,ZHAO Si-wen,et al.Determination of Seven Dimethylcyclosiloxanes in Cosmetics by Gas Chromatography-Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2023,42(12):1607-1614. DOI： 10.19969/j.fxcsxb.23091802.

摘要

建立了气相色谱-串联质谱法（GC-MS/MS）测定化妆品中7种二甲基环硅氧烷的检测方法。将不同基质化妆品经异丙醇分散、正己烷提取后，以HP-5MS UI毛细管色谱柱（30 m×0.25 mm×0.25 μm）分离，采用GC-MS/MS多重反应监测（MRM）模式检测，基质匹配外标法定量。结果显示，7种二甲基环硅氧烷在50~1 000 ng/mL范围内线性关系良好，相关系数（,R,）为0.996 5~ 0.999 9；方法检出限（LOD）为4.0~6.1 mg/kg，定量下限（LOQ）为13.2 ~ 20.4 mg/kg，平均加标回收率为85.1%~115%，相对标准偏差（RSD）为0.90%~7.0%。采用该方法对市售的102批化妆品进行检测，检出组分涵盖了D4~D9。该方法简便、快速、灵敏、准确，适用于化妆品中7种二甲基环硅氧烷的监测，为保障化妆品的质量安全提供了技术支撑。

Abstract

A gas chromatography-tandem mass spectrometric（GC-MS/MS） method was developed for the simultaneous determination of 7 dimethylcyclosiloxanes in cosmetics. Cosmetics samples with different matrices were dispersed with isopropyl alcohol and extracted with ,n,-hexane，then separated on a HP-5MS UI capillary column（30 m×0.25 mm×0.25 μm），and detected by GC-MS/MS in multiple reactive ion monitoring（MRM） mode. The data were processed and quantified using the matrix-matched external standard method. The results showed that the 7 dimethylcyclosiloxanes had good linear relationships in the range of 50-1 000 ng/mL，with correlation coefficients（,R,） of 0.996 5-0.999 9. The limits of detection（LODs） and the limits of quantitation（LOQs） were in the range of 4.0-6.1 mg/kg and 13.2-20.4 mg/kg，respectively. The average recoveries were in the range of 85.1%-115%，with relative standard deviations（RSDs） of 0.90%-7.0%. The method was applied to test 102 batches of cosmetics sold on the market，and the detected components covered D4-D9. The method is convenient，fast，sensitive and accurate，which is suitable for the determination of the 7 dimethylcyclosiloxanes in cosmetics and could provide technical support for ensuring the quality and safety of cosmetics.

关键词

气相色谱-串联质谱（GC-MS/MS）二甲基环硅氧烷化妆品

Keywords

gas chromatography-tandem mass spectrometry（GC-MS/MS）dimethylcyclosiloxanes（DMCs）cosmetics

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Related Institution

Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology，Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine，Institute of Analysis，Guangdong Academy of Sciences（China National Analytical Center，），Guangzhou

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