Simultaneous Determination of 9 Self-heating Compounds Including Capsaicin in Cosmetics by High Performance Liquid Chromatography

WU Zhi-shan; WU Jiao-jiao; YIN Wei-cheng; YIN Shuai; LI Zhuo-fang; JIANG Cheng-jun

doi:10.19969/j.fxcsxb.23011902

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Simultaneous Determination of 9 Self-heating Compounds Including Capsaicin in Cosmetics by High Performance Liquid Chromatography

Experimental Techniques and Methods | 更新时间：2023-05-15

- Simultaneous Determination of 9 Self-heating Compounds Including Capsaicin in Cosmetics by High Performance Liquid Chromatography
- Journal of Instrumental Analysis Vol. 42, Issue 5, Pages: 641-646(2023)
- 作者机构：
  
  1.湖南省药品检验检测研究院，湖南长沙 410001
  2.岳阳市食品药品检验所，湖南岳阳 414000
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.23011902
  CLC：
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吴志珊,吴姣娇,尹伟成等.高效液相色谱法同时测定化妆品中辣椒碱等9种热感剂[J].分析测试学报,2023,42(05):641-646.

WU Zhi-shan,WU Jiao-jiao,YIN Wei-cheng,et al.Simultaneous Determination of 9 Self-heating Compounds Including Capsaicin in Cosmetics by High Performance Liquid Chromatography[J].Journal of Instrumental Analysis,2023,42(05):641-646.
吴志珊,吴姣娇,尹伟成等.高效液相色谱法同时测定化妆品中辣椒碱等9种热感剂[J].分析测试学报,2023,42(05):641-646. DOI： 10.19969/j.fxcsxb.23011902.

WU Zhi-shan,WU Jiao-jiao,YIN Wei-cheng,et al.Simultaneous Determination of 9 Self-heating Compounds Including Capsaicin in Cosmetics by High Performance Liquid Chromatography[J].Journal of Instrumental Analysis,2023,42(05):641-646. DOI： 10.19969/j.fxcsxb.23011902.

摘要

建立了测定化妆品中辣椒碱等9种热感剂的高效液相色谱法。样品经80%甲醇超声提取后，过滤，以乙腈-0.5%甲酸水溶液为流动相，采用SymmetryShield,TM,RP18色谱柱（250 mm × 4.6 mm，5 μm）分离，液相色谱分离，二极管阵列检测器进行检测。在优化实验条件下，9种热感剂的分离度好，专属性高，其质量浓度在0.2 ~ 100 μg/mL范围内与峰面积呈良好线性关系，相关系数（,r,2,）均不小于0.999 5，检出限（LOD）为0.001 0 ~ 0.003 4 mg/kg。以水基类、乳剂类、膏霜类3种阴性样品作为空白基质，9种热感剂在0.004、0.02、1 mg/kg 3种加标水平下的回收率为75.6% ~ 115%，相对标准偏差（RSD）为0.083% ~ 7.0%。该方法专属性强、灵敏度高、准确度好，可用于化妆品中9种热感剂含量的测定。

Abstract

A high performance liquid chromatographic（HPLC） method was established for the determination of 9 self-heating compounds，including capsaicin in cosmetics．The samples were ultrasonically extracted with 80% methanol，and then filtered．The target compounds were separated on a SymmetryShield,TM,RP18（250 mm × 4.6 mm，5 μm） with a mobile phase consisting of acetonitrile and 0.5% formic acid by gradient elution，and analyzed by HPLC with a PDA detector．Under the optimal conditions，good linear relationships were obtained for nine compounds in the concentration range of 0.2－100 μg/mL，with correlation coefficients（,r,2,） not less than 0.999 5．The limits of detection（LODs） were in the range of 0.001 0－0.003 4 mg/kg．The spiked recoveries for water，lotion and cream matrixes at three levels of 0.004，0.02，1 mg/kg ranged from 75.6% to 115%，with relative standard deviations（RSDs，,n, = 3） of 0.083%－7.0%．This method is accurate and sensitive，and is suitable for the qualitative and quantitative analysis of 9 self-heating compounds in cosmetics.

关键词

热感剂化妆品高效液相色谱法（HPLC）

Keywords

self-heating compoundscosmeticshigh performance liquid chromatography（HPLC）

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深圳市食品安全检测技术研发重点实验室

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