Portable Detection of Ca<sup>2+</sup> Using Writing Robots Drawing Paper-based Microfluidic Chips

LIU Xu; GAO Guo-wei; HU Jing-fang; ZHANG Kai-yu; LI Yan-sheng

doi:10.19969/j.fxcsxb.22060501

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Portable Detection of Ca²⁺ Using Writing Robots Drawing Paper-based Microfluidic Chips

Scientific Papers | 更新时间：2023-01-04

- Portable Detection of Ca²⁺ Using Writing Robots Drawing Paper-based Microfluidic Chips
- Journal of Instrumental Analysis Vol. 41, Issue 11, Pages: 1607-1613(2022)
- 作者机构：
  
  1.北京信息科技大学传感器实验室，北京 100101
  2.北京信息科技大学现代测控技术教育部重点实验室，北京 100192
  3.中国科学院上海微系统与信息技术研究所传感技术联合国家重点实验室，上海 200050
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.22060501
  CLC：
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刘旭,高国伟,胡敬芳等.写字机器人绘制纸基微流控芯片便携检测Ca²⁺[J].分析测试学报,2022,41(11):1607-1613.

LIU Xu,GAO Guo-wei,HU Jing-fang,et al.Portable Detection of Ca²⁺ Using Writing Robots Drawing Paper-based Microfluidic Chips[J].Journal of Instrumental Analysis,2022,41(11):1607-1613.
刘旭,高国伟,胡敬芳等.写字机器人绘制纸基微流控芯片便携检测Ca²⁺[J].分析测试学报,2022,41(11):1607-1613. DOI： 10.19969/j.fxcsxb.22060501.

LIU Xu,GAO Guo-wei,HU Jing-fang,et al.Portable Detection of Ca²⁺ Using Writing Robots Drawing Paper-based Microfluidic Chips[J].Journal of Instrumental Analysis,2022,41(11):1607-1613. DOI： 10.19969/j.fxcsxb.22060501.

摘要

纸基微流控芯片是一种纸质基底芯片，具有性能优良、价格低廉的优势，然而其制备技术多依赖专业昂贵的设备，限制了纸基微流控芯片的发展。该文采用成本低廉的家用写字机器人，将具有敏感特性的智能水凝胶绘制在纸质基底材料上，得到具有水凝胶阀门的纸基微流控芯片。以Ca,2+,为模型靶标，该纸基微流控芯片能实现不同浓度（0.1 ~ 50 mmol/L）Ca,2+,溶液的裸眼定量检测，并具有很好的易用性和重现性。同时采用ILX506 CCD传感器制作纸基微流控芯片的数字显示设备，以实现芯片测量结果的自动读取功能。该方法能快速便捷、低成本地制备多条纸基微流控芯片，为其普适化制备提供了新的研究思路，在发展中地区具有良好的推广前景。

Abstract

The paper-based microfluidic chips are a kind of paper-based chips，which have the advantages of excellent performance，low price，safety and portability．However，the preparation technology for paper-based microfluidic chips mostly depends on the professional and expensive equipments，which limits their development to a certain extent．And it is not conducive to the commercialization process for paper-based microfluidic chips．In this paper，a paper-based microfluidic chip with hydrogel valve was developed by using a low-cost，simple home writing robot to draw a smart hydrogel with sensitive properties on a paper base．In order to verify the feasibility of the preparation method，Ca,2+, was used as a model target．Results showed that the paper-based microfluidic chip prepared by this method could achieve the quantitative detection of Ca,2+, solutions in the concentration range of 0.1－50 mmol/L with the naked eye，which has good usability and reproducibility．Meanwhile，a ILX506 CCD sensor was used to design and optimize the digital display device of the paper-based microfluidic chip so as to realize the automatic reading function for the measurement results of paper-based microfluidic chip．The experimental results showed that this method could be used for the rapid and convenient preparation of multiple paper-based microfluidic chips at low cost．The preparation method provides a new research idea for the ubiquitous preparation of paper-based microfluidic chips，which has a good promotion prospect in those developing regions.

关键词

纸基微流控芯片写字机器人水凝胶快速检测可视化定量检测

Keywords

paper-based microfluidic chipwriting robothydrogelrapid detectionvisual quantitative detection

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Portable Detection of Ca2+ Using Writing Robots Drawing Paper-based Microfluidic Chips

DOI：10.19969/j.fxcsxb.22060501

摘要

Abstract

关键词

Keywords

references

Portable Detection of Ca²⁺ Using Writing Robots Drawing Paper-based Microfluidic Chips