Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids

XU Fang-min; LI Hai-bo; WEI Wan-li; WANG Rui-hua; LIU Ling-yun; LI Qiang

doi:10.19969/j.fxcsxb.21102504

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Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids

Scientific Papers | 更新时间：2022-07-15

- Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids
- Journal of Instrumental Analysis Vol. 41, Issue 7, Pages: 1030-1035(2022)
- 作者机构：
  
  1.江苏省江阴市公安局物证鉴定室，江苏江阴 214431
  2.江苏省常州市公安局物证鉴定所，江苏常州 213003
  3.江苏省无锡市公安局物证鉴定所，江苏无锡 214001
  4.公安部物证鉴定中心，北京 110038
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.21102504
  CLC：
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徐仿敏,李海波,魏万里等.吲唑酰胺类合成大麻素的EI质谱特征分析[J].分析测试学报,2022,41(07):1030-1035.

XU Fang-min,LI Hai-bo,WEI Wan-li,et al.Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids[J].Journal of Instrumental Analysis,2022,41(07):1030-1035.
徐仿敏,李海波,魏万里等.吲唑酰胺类合成大麻素的EI质谱特征分析[J].分析测试学报,2022,41(07):1030-1035. DOI： 10.19969/j.fxcsxb.21102504.

XU Fang-min,LI Hai-bo,WEI Wan-li,et al.Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids[J].Journal of Instrumental Analysis,2022,41(07):1030-1035. DOI： 10.19969/j.fxcsxb.21102504.

摘要

采用气相色谱－质谱联用技术（GC－MS）对 9 种吲唑酰胺类合成大麻素（MDMB－CHMINACA、5F－AB－PINACA、5F－AMB、AB－CHMINACA、AB－FUBINACA、AB－PINACA、MDMB－FUBINACA、AMB－FUBINACA、ADB－BUTINACA）在电子轰击（EI）电离模式下产生的主要碎片离子和碎裂过程进行分析，并对所获得的质谱图进行解析，推测该类物质的EI碎裂规律。结果表明，在EI模式下，吲唑酰胺类合成大麻素的吲唑3号位酰胺基C—N键的断裂是主要碎裂方式，在碎裂过程中还存在麦氏重排。该研究总结了吲唑酰胺类合成大麻素在EI模式下的主要碎片离子和质谱特征，归纳了EI的特征碎裂规律，可为吲唑酰胺类合成大麻素的结构推断与鉴定提供参考。

Abstract

A gas chromatography－mass spectrometry（GC－MS） was applied to investigate the mass fragmentation characteristics of 9 indazole-3-carboxamide analogues synthetic cannabinoids in electron ionization（EI），including MDMB－CHMINACA，5F－AB－PINACA，5F－AMB，AB－CHMINACA，AB－FUBINACA，AB－PINACA，MDMB－FUBINACA，AMB－FUBINACA and ADB－BUTINACA．The obtained mass spectra were analyzed and the EI fragmentation patterns of indazole-3-carboxamide analogues synthetic cannabinoids were speculated．Results showed that in the EI mode，the C—N cleavage of the amide group connected to the indazole ring at position 3 is the main fragmentation pathway，and the McLafferty rearrangement was happened during the fragmentation．The main fragmentation ions and mass fragmentation characteristic of indazole-3-carboxamide analogues synthetic cannabinoids in EI modes were summarized in this paper，which is useful for identification on the new psychoactive substances of unknown indazole-3-carboxamide analogues synthetic cannabinoids in practical work．

关键词

新精神活性物质合成大麻素吲唑酰胺类气相色谱质谱特征

Keywords

new psychoactive substancessynthetic cannabinoidsindazole-3-carboxamidegas chromatographymass fragmentation characteristics

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