Determination of Migration of 9 Phenols in Food Contact Materials by High Performance Liquid Chromatography

LIU Gui-hua; SU Feng; LI Wei; KOU Hai-juan; XU Jie; LI Xiao-man; LUO Shi-peng

doi:10.19969/j.fxcsxb.21073011

您当前的位置：

首页 >

文章列表页 >

Determination of Migration of 9 Phenols in Food Contact Materials by High Performance Liquid Chromatography

Scientific Papers | 更新时间：2023-02-13

- Determination of Migration of 9 Phenols in Food Contact Materials by High Performance Liquid Chromatography
- Journal of Instrumental Analysis Vol. 40, Issue 11, Pages: 1619-1626(2021)
- 作者机构：
  
  1.常州工业及消费品检验有限公司，江苏常州 213017
  2.南京海关危险货物与包装检测中心，江苏常州 213022
  3.江苏理工学院化学与环境工程学院，江苏常州 213001
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.21073011
  CLC：
扫描看全文
刘桂华,苏凤,李威等.高效液相色谱法测定食品接触材料及制品中9种酚类物质的迁移量[J].分析测试学报,2021,40(11):1619-1626.

LIU Gui-hua,SU Feng,LI Wei,et al.Determination of Migration of 9 Phenols in Food Contact Materials by High Performance Liquid Chromatography[J].Journal of Instrumental Analysis,2021,40(11):1619-1626.
刘桂华,苏凤,李威等.高效液相色谱法测定食品接触材料及制品中9种酚类物质的迁移量[J].分析测试学报,2021,40(11):1619-1626. DOI： 10.19969/j.fxcsxb.21073011.

LIU Gui-hua,SU Feng,LI Wei,et al.Determination of Migration of 9 Phenols in Food Contact Materials by High Performance Liquid Chromatography[J].Journal of Instrumental Analysis,2021,40(11):1619-1626. DOI： 10.19969/j.fxcsxb.21073011.

摘要

该文建立了苯酚、甲酚类、二甲酚类等9种酚类物质迁移量同时测定的高效液相色谱（HPLC）检测方法。采用Agilent ZORBAX SB－Aq色谱柱进行分离，以甲醇－水为流动相梯度洗脱，流速1.0 mL/min，荧光检测器测定，激发波长为214 nm，发射波长为315 nm。优化了含油脂食品模拟物中9种酚类物质的提取方式，并考察了线性范围、准确度及精密度等方法性能参数。研究结果表明，含油脂食品模拟物中9种酚类物质的最佳提取溶剂为67%甲醇溶液，9种酚类物质在水基及油脂类食品模拟物中的线性相关系数（,r,2,）均高于0.999，回收率为90.7%～99.8%，相对标准偏差均低于6.0%。5种水基食品模拟物中9种酚类物质的定量下限为0.07～0.10 mg/L，橄榄油中9种酚类物质的定量下限为0.15～0.20 mg/kg。方法成功应用于11批食品接触用聚碳酸酯（PC）塑料制品、15批涂层制品中9种酚类物质迁移量的测定。该方法灵敏度高、精密度好，可为食品接触材料及制品中9种酚类物质迁移量的分析提供技术支持。

Abstract

A high performance liquid chromatographic（HPLC） method was established for the simultaneous determination of 9 phenols such as phenol，methyl-phenols and xylenols in food simulants. The sample was separated on an Agilent ZORBAX SB－Aq column by gradient elution，using methanol and water as mobile phase at a flow rate of 1.0 mL/min，and finally determined by fluorescence detection at an excitation wavelength of 214 nm and an emission wavelength of 315 nm．Meanwhile，the extraction method for 9 phenols in the fat-contained simulant was optimized，and the performances of the method including linearity，spiked recovery and precision were studied．Results demonstrated that 67% methanol aqueous solution was the best extraction solvent for the 9 phenols in fat simulants．The results also showed that there were good linear relationships for 9 phenols in all food simulants studied，with correlation coefficients（,r,2,） higher than 0.999．The recoveries for 9 phenols at 3 spiked levels in all food simulants ranged from 90.7% to 99.8%，with relative standard deviations （RSD） all below 6.0%．The limits of quantitation（LOQs） were in the ranges of 0.07－0.10 mg/L for aqueous simulants，and 0.15－0.20 mg/kg for fat simulants. This method was successfully applied to the migration determination of 9 phenols released from 11 plastics articles（PC） and 15 coatings intended to contact with food．The method was sensitive and accurate，and was suitable for the determination of 9 phenols in food simulants.

关键词

酚类物质迁移食品接触材料高效液相色谱法（HPLC）荧光检测器

Keywords

phenolsmigrationfood contact materialshigh performance liquid chromatography （HPLC）fluorescence detector

references

GB 9685－2016．National Food Safety Standard for the Use of Additives for Food Contact Materials and Articles．National Standard of the People's Republic of China（食品安全国家标准食品接触材料及制品用添加剂使用标准．中华人民共和国国家标准）．

GB 4806.1－2016．National Food Safety Standard for General Safety Requirements for Food Contact Materials and Articles．National Standard of the People's Republic of China（食品安全国家标准食品接触材料及制品通用安全要求．中华人民共和国国家标准）．

Commision Regulation（EU）．No. 10/2011 of 14 January 2011 on Plastic Materials and Articles Intended to Come Into Contact with Food．European Union.

GB 31604.46－2016．National Food Safety Standard Food Contact Materials and Articles Determination of Residue and Migration of Free Phenols．National Standard of the People's Republic of China（食品安全国家标准食品接触材料及制品游离酚的测定和迁移量的测定．中华人民共和国国家标准）．

ISO 119－1977．Plastics Phenol－formaldehyde Mouldings Determination of Free Phenols： Iodometric Method．International Organization for Standardization.

Gao Y T，Liu G H，Shang G Q．J. Food Saf. Qual. （高亚婷，刘桂华，商贵芹．食品安全质量检测学报），2020，11（14）：4821－4828.

Bai WW，Liu S H，Cao J P，Fan Y Y，Xie Q L．Chin. J. Chromatogr. （白玮玮，刘书慧，曹江平，范盈盈，解启龙．色谱），2013，31（3）：254－259．

Li G H，Liu Z P，Qiu K，Wu G，Huang W，Sui H X，Zhong Q D．Food Ferment. Ind. 李国辉，刘兆平，仇凯，吴刚，黄文，隋海霞，钟其顶．食品与发酵工业），2018，44（12）：73－79.

Zhu H H，Xing W Q，Wang M，Wang S T．Packag. Food Mach. （朱昊浩，邢伟齐，王敏，汪仕韬．包装与食品机械），2019，37（5）：63－67.

Guo M M，Liu X H，Lü Y K，Ma J Q．J. Food Saf. Qual. （郭萌萌，刘雪卉，吕运开，马俊琴．食品安全质量检测学报），2016，7（1）：285－290.

Wang J，Wang W S，Su B Y，Li Y J，Zhang Z L．Plast. Sci. Technol. （王君，王微山，苏本玉，李玉江，张智力．塑料科技），2018，46（9）：128－132.

ISO 8974－2002．Plastics Phenolic Resins Determination of Residual Phenol Content by Gas Chromatography．International Organization for Standardization.

Liang J N，Tan H，Wang D，Guo Z J，Wang R F，Li W W．Chem. Anal. Meterage（梁健能，谭辉，王迪，郭泽瑾，王瑞锋，李伟伟．化学分析计量），2018，27（4）： 55－59.

Qiu F Y，Ding L，Chen X M，Cao H Y，Chen X T，Hong Y P．Chem. Anal. Meterage（邱丰艳，丁力，陈雪梅，曹红云，陈晓婷，洪燕萍．化学分析计量），2020，29（1）： 35－39.

GB 31604.1－2015．National Standard for Food Safety．Food Contact Materials and Products General Rules for Migration Tests．National Standards of the People's Republic of China（食品安全国家标准食品接触材料及制品迁移试验通则．中华人民共和国国家标准）.

GB 5009.156－2016．National Standard for Food Safety．Food Contact Materials and Products General Rules of Migration Test Pretreatment Method．National Standards of the People's Republic of China（食品安全国家标准食品接触材料及制品迁移试验预处理方法通则．中华人民共和国国家标准）.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Determination of Acrylamide Migration in Paper-based Food Contact Materials by Ultra Performance Liquid Chromatography－Tandem Mass Spectrometry

Screening of Specified Risk Materials in Disposable Plastic Tableware

Determination of Migration of Six Cyclosiloxanes in Silicone Rubber Products for Food Contact by GC－MS/MS

Proficiency Testing of Potassium Permanganate Consumption in Food Contact Materials and Its Application Assessment

Non-targeted Screening and Risk Assessment of Nonvolatile Migrants in Paper Straws

Related Author

No data

Related Institution

Changzhou Safety Testing Center for Entry－Exit Industrial and Consumable Products

Ningbo Joysun Product Testing Co.，Ltd.

Ningbo Institute of Inspection and Quarantine Science and Technology

Ningbo Customs District Technology Center

Department of Food Science and Engineering，Jinan University

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰