A Study on the On-line Monitoring of Xuefu Zhuyu Capsules Extraction Process Using Near Infrared Spectroscopy Combined with Multivariate Statistical Process Control Technology

WANG Xi; YANG Ying-lian; SHA Xin; SONG Wen; ZHANG Ying; YU He-shui; LI Zheng; LI Wen-long

doi:10.12452/j.fxcsxb.24040102

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A Study on the On-line Monitoring of Xuefu Zhuyu Capsules Extraction Process Using Near Infrared Spectroscopy Combined with Multivariate Statistical Process Control Technology

Experimental Techniques and Methods | 更新时间：2024-11-26

- A Study on the On-line Monitoring of Xuefu Zhuyu Capsules Extraction Process Using Near Infrared Spectroscopy Combined with Multivariate Statistical Process Control Technology
- Journal of Instrumental Analysis Vol. 43, Issue 11, Pages: 1821-1828(2024)
- 作者机构：
  
  1.天津中医药大学中药制药工程学院，天津 301617
  2.现代中医药海河实验室，天津 301617
  3.天津宏仁堂药业有限公司，天津 300380
  4.天津市中药智能制药与绿色制药重点实验室，天津 301617
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.24040102
  CLC： O657.3;R283
- Published：15 November 2024，
  
  Received：01 April 2024，
  
  Revised：12 May 2024，
- 稿件说明：
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王玺,杨应莲,沙鑫,宋纹,张营,余河水,李正,李文龙.近红外光谱结合多元统计过程控制技术在血府逐瘀胶囊提取过程在线监测中的研究[J].分析测试学报,2024,43(11):1821-1828.

WANG Xi,YANG Ying-lian,SHA Xin,SONG Wen,ZHANG Ying,YU He-shui,LI Zheng,LI Wen-long.A Study on the On-line Monitoring of Xuefu Zhuyu Capsules Extraction Process Using Near Infrared Spectroscopy Combined with Multivariate Statistical Process Control Technology[J].Journal of Instrumental Analysis,2024,43(11):1821-1828.
王玺,杨应莲,沙鑫,宋纹,张营,余河水,李正,李文龙.近红外光谱结合多元统计过程控制技术在血府逐瘀胶囊提取过程在线监测中的研究[J].分析测试学报,2024,43(11):1821-1828. DOI： 10.12452/j.fxcsxb.24040102.

WANG Xi,YANG Ying-lian,SHA Xin,SONG Wen,ZHANG Ying,YU He-shui,LI Zheng,LI Wen-long.A Study on the On-line Monitoring of Xuefu Zhuyu Capsules Extraction Process Using Near Infrared Spectroscopy Combined with Multivariate Statistical Process Control Technology[J].Journal of Instrumental Analysis,2024,43(11):1821-1828. DOI： 10.12452/j.fxcsxb.24040102.

摘要

建立了多元统计过程控制（MSPC）模型对血府逐瘀胶囊提取过程进行在线监控。采用近红外（NIR）光谱仪在线采集多批血府逐瘀胶囊提取过程光谱数据，利用过程光谱进行主成分分析（PCA），建立血府逐瘀胶囊提取过程轨迹图，以反映提取过程随时间变化的趋势。结合MSPC建立主成分得分（PC score）、DModX和Hotelling T

控制模型监测提取过程，生成PC score图、Hotelling T

图及DMod X控制图。PC1得分图采用±3 SD为控制限，反映PC随提取过程状态波动的情况；DModX控制图采用＋3SD作为控制限，反映采样点偏离模型的绝对距离；Hotelling T

图以95%为控制限，反映各批次采样点偏离PCA模型中心的距离。应用正常批次的过程光谱建立3种MSPC控制模型直接观察血府逐瘀胶囊提取过程的整体变化，3种控制模型联合使用可对加水量、提取温度及缺味异常批次进行及时准确地识别。MSPC技术快速、无损，NIRS结合MSPC技术可应用于血府逐瘀胶囊提取过程的在线监测，对提升中药生产质量具有参考意义。

Abstract

To establish a multivariate statistical process control（MSPC） model for the extraction process of Xuefu Zhuyu capsules，and to monitor the extraction process on-line. Near infrared（NIR） spectrometer was used to collect spectral data of on-line extraction process of multiple batches of Xuefu Zhuyu capsules. The process spectra were used for principal component analysis（PCA） to establish a trajectory chart of the extraction process of Xuefu Zhuyu capsules，it reflects the trend of the extraction process over time. In addition，a principal component score（PC score），DModX，and Hotellin

g T

control models were established in conjunction with MSPC to monitor the extraction process. The PC score charts，DModX charst，and Hotelling T

control charts were generated. The PC1 score chart uses ±3 SD as the control limit，reflecting the fluctuation of PC with the process state；The DModX control chart uses +3 SD as the control limit，reflecting the absolute distance of sampling points from the model，and is a measure of the degree of external data changes in the model；The Hotelling T

chart uses 95% as the control limit，reflecting the distance of sampling points from the center of the PCA model for each batch. Establishing three MSPC control models using process spectra from normal batches can directly observe the overall changes in the extraction process of Xuefu Zhuyu capsules. The combination of the three control models can timely and accurately identify batches with abnormal water addition，extraction temperature，and missing materials. MSPC technology is faster and more non-destructive compared with traditional off-line detection methods.The combination of NIRS and MSPC technology can be fully applied to on-line monitoring of the extraction process of Xuefu Zhuyu capsules，which has reference significance for improving the quality of traditional Chinese medicine production.

关键词

近红外光谱多元统计过程控制血府逐瘀胶囊在线监测主成分分析

Keywords

near infrared spectroscopymultivariate statistical process controlXuefu Zhuyu capsuleson-line monitoringprincipal component analysis

references

Zhang X Y. J. Chin. Presc. Drug（张秀瑛. 中国处方药），2023，21（10）：179-181.

Gao R，Yang Z Q. Chin. J. New Drugs（高蕊，杨忠奇. 中国新药杂志），2023，32（4）：338-347.

Zhang X Y，Jiang Z Z，Zhang L，Xue C，Feng X F，Chai X，Wang Y F. Chin. Herb. Med.，2023，15（1）：139-150.

Huang Y X，Liu E W，Huang X H，Hao J，Hu S Y，Gao X M. Chin. Herb. Med.，2023，15（2）：263-270.

Zhang X C，Meng Q F，Guan J L，Wang Y，Gong X C. Central South Pharm.（张雪灿，孟庆芬，关建丽，王毅，龚行楚. 中南药学），2023，21（1）：123-129.

Gao H. Study on the Effect and Mechanism of Safflower Yellow Pigment Intervention on Coronary Heart Disease Blood Stasis Syndrome and Obesity. Xianyang：Shaanxi University of Chinese Medicine（高欢. 红花黄色素干预冠心病血瘀证和肥胖症的作用及机制研究. 咸阳：陕西中医药大学），2023.

Tang X H，Ren C X，Hu J，Chen J，Wang J，Wang R，Wu Q H，Liao W，Pei J. Chin. Herb. Med.，2023，15（2）：291-297.

Duan S，Wu X T，Li B. Food Sci. Technol.（段帅，吴晓彤，李博. 食品科技），2020，45（9）：233-237.

Xiong H S，Tian G，Liu P，Zhao W S，Li C M，Zhu Y H，Ye Z L，Zhang S N，Yan K J. Chin. Tradit. Herb. Drugs（熊皓舒，田埂，刘朋，赵万顺，李晨鸣，朱永宏，叶正良，章顺楠，闫凯境. 中草药），2020，51（16）：4331-4337.

Wu S J，Wang L，Zhou G M，Liu C，Ji Z R，Li Z，Li W L. Food. Res. Int.，2023，163：112192.

Yang P. Study on the Transfer Method of Near Infrared Quantitative Model of Water Content from Small Scale to Medium Scale in Fluidized Bed Granulation Process. Beijing：Beijing University of Traditional Chinese Medicine（杨培. 流化床制粒过程小试水分近红外定量模型向中试传递方法研究. 北京：北京中医药大学），2020.

Wu S J. Studies on the End-point Determination Methods of Pharmaceutical Technics of Traditional Chinese Medicine Based on Near Infrared Spectroscopy. Tianjin：Tianjin University of Traditional Chinese Medicine（吴思俊. 基于近红外光谱技术的中药制药工艺终点判断方法研究. 天津：天津中医药大学），2021.

Guo H J，Weng W F，Zhao H N，Wen J F，Li R，Li J N，Zeng C B，Ji S G. Spectrochim. Acta A，2021，251：119426.

Chen H，Tan C，Lin Z，Li H J. Spectrochim. Acta A，2019，211：280-286.

Yin L H，Zhou J M，Chen D D，Han T T，Zheng B S，Younis A，Shao Q S. Spectrochim. Acta A，2019，221：117208.

Liu R H，Sun Q F，Hu T，Li L，Nie L，Wang J Y，Zhou W H，Zang H C. Spectrochim. Acta A，2018，192：75-81.

Schat E，Tuerlinckx F，Smit A C，De Ketelaere B，Ceulemans E. Psychol. Methods，2023，28（6）：1335-1357.

An S Y，Zhang L，Yue H S，Liu W Y，Ju A C. Central South Pharm.（安思宇，张磊，岳洪水，柳文媛，鞠爱春. 中南药学），2019，17（9）：1439-1445.

Zhao Y，Hu C Q，Yao S C，Yin L H，Ling X M. Chin. J. New Drugs（赵瑜，胡昌勤，姚尚辰，尹利辉，凌笑梅. 中国新药杂志），2020，29（12）：1355-1362.

Shang X Z，Hou J，Li D K，Zhang L. Drug Eval. Res.（尚献召，侯健，李德坤，张磊. 药物评价研究），2023，46（8）：1679-1685.

Zhu J Y，Zeng J Q，Li Q Q，Ma L J，Lu Y，Zhang H，Zheng Y F，Wu C Y，Wu Z S. China J. Chin. Mater. Med.（朱金媛，曾敬其，李倩倩，马丽娟，陆影，张瀚，郑燕飞，吴春媛，吴志生. 中国中药杂志），2021，46（7）：1629-1635.

Xu M，Zhang L，Yue H S，Pang H W，Ye Z L，Ding L. China J. Chin. Mater. Med.（徐敏，张磊，岳洪水，庞洪伟，叶正良，丁黎. 中国中药杂志），2017，42（20）：3906-3911.

Guo Z Q，Liu F L，Duan Q N，Wang W J，Wang Q R，Huang Y C，Zhao Y T，Liu L，Feng Y J，Xia L B，Gao H，Long Y W，Yao D，Lee J C. Envion. Res.，2023，216（4）：114812.

Zhang H，Dean L，Wang M L，Dang P，Lamb M，Chen C. Front. Plant Sci.，2023，14：1204415.

Hermann M，Umlauf G，Goldlücke B，Franz M O. Sensors（Basel），2022，22（19）：7674.

Vitale R，Spinaci G，Marini F，Marion P，Delcroix M，Vieillard A，Coudon F，Devos O，Ruckebusch C. Talanta，2022，243：123360.

Hua H M. Application of Near-infrared Spectroscopy Technology in the Extraction Process of Poria Cocos Polysaccharides. Guangzhou：Guangdong Pharmaceutical University（华海敏. 近红外光谱技术在茯苓多糖提取过程中的应用研究. 广州：广东药科大学），2021.

Wu S J，Wang L，Wu H G，He X L，Qiu P，Li Z，Li W L. J. Instrum. Anal.（吴思俊，王龙，吴红根，贺兴立，仇萍，李正，李文龙. 分析测试学报），2022，41（1）：121-127.

Yang Y，Wang L，Liu X S，Wu Y J，Bi Y A，Xiao W，Chen Y. Chin. Tradit. Herb. Drugs（杨越，王磊，刘雪松，吴永江，毕宇安，萧伟，陈勇. 中草药），2017，48（17）：3497-3504.

Hou Y Z，Li P，Xiao H M，Chen J L，Li Z，Li W L. Chin. Herb. Med.（侯一哲，黎翩，肖红敏，陈景丽，李正，李文龙. 中草药），2019，50（11）：2552-2559.

Li W L，Wang X，Chen H L，Yan X，Qu H B. Separations，2022，9（11）：378.

Wen P，Huan K W，Zhao H，Wang D. J. Changchun Univ. Sci. Technol.：Nat. Sci. Ed. （文鹏，宦克为，赵环，王迪. 长春理工大学学报：自然科学版），2024，47（1）：23-28.

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