Study of a Glucose Sensor Based on Carbon Dots/Glucose Oxidase Co-encapsulates Metal-Organic Framework

ZHANG Chi; GE Xin-yu; CHEN Da-wei; WU Yong-ning

doi:10.12452/j.fxcsxb.24032802

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Study of a Glucose Sensor Based on Carbon Dots/Glucose Oxidase Co-encapsulates Metal-Organic Framework

Experimental Techniques and Methods | 更新时间：2024-07-08

- Study of a Glucose Sensor Based on Carbon Dots/Glucose Oxidase Co-encapsulates Metal-Organic Framework
- Journal of Instrumental Analysis Vol. 43, Issue 7, Pages: 1058-1062(2024)
- 作者机构：
  
  1.北京工商大学食品与健康学院，北京 100048
  2.国家食品安全风险评估中心，北京 100021
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.24032802
  CLC： O657.3;TS236.3
- Published：15 July 2024，
  
  Received：28 March 2024，
  
  Revised：30 April 2024，
- 稿件说明：
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张弛,葛鑫禹,陈达炜,吴永宁.基于碳点/葡萄糖氧化酶共包裹金属有机框架的葡萄糖传感器研究[J].分析测试学报,2024,43(07):1058-1062.

ZHANG Chi,GE Xin-yu,CHEN Da-wei,WU Yong-ning.Study of a Glucose Sensor Based on Carbon Dots/Glucose Oxidase Co-encapsulates Metal-Organic Framework[J].Journal of Instrumental Analysis,2024,43(07):1058-1062.
张弛,葛鑫禹,陈达炜,吴永宁.基于碳点/葡萄糖氧化酶共包裹金属有机框架的葡萄糖传感器研究[J].分析测试学报,2024,43(07):1058-1062. DOI： 10.12452/j.fxcsxb.24032802.

ZHANG Chi,GE Xin-yu,CHEN Da-wei,WU Yong-ning.Study of a Glucose Sensor Based on Carbon Dots/Glucose Oxidase Co-encapsulates Metal-Organic Framework[J].Journal of Instrumental Analysis,2024,43(07):1058-1062. DOI： 10.12452/j.fxcsxb.24032802.

摘要

建立了高稳定性的血清中葡萄糖的检测方法。通过将葡萄糖氧化酶（GOx）、碳点（CDs）共同包封在类沸石咪唑酯骨架（ZIF-8）材料中制备了纳米复合材料GOx/CDs@ZIF-8。在中性条件下，该复合材料可高效催化氧化葡萄糖生成H

，随后H

与Co

通过类芬顿反应产生自由基（·OH），该自由基可使碳点的荧光发生猝灭，基于此构建了血清中葡萄糖的荧光检测方法。在优化条件下，该荧光探针的检出限为0.16 μmol/L，回收率为91.0% ~108%。所构建的纳米荧光探针可用于实际样品中葡萄糖的检测，且在常温下具有较高的稳定性。

Abstract

A highly stable method for the detection of glucose in serum was developed. The nanocomposite GOx/CDs@ZIF-8 was prepared by co-encapsulating glucose oxidase（GOx） and carbon dots（CDs） in a zeolitic imidazolate framework material（ZIF-8）. Under neutral conditions，this nanocomposite material can efficiently catalyze the oxidation of glucose to produce H

，and then free radicals（·OH） were produced via a Fenton-like reaction from the H

and Co

. The free radical can burst the fluorescence of carbon dots，based on which，a fluorescence detection method for glucose in serum was constructed. Under the optimized conditions，the detection limit of the fluorescent probe was 0.16 μmol/L，and the recoveries were 91.0%-108%. The constructed nano fluorescent probe can be used for the detection of glucose in real samples and has high stability at room temperature.

关键词

纳米复合材料荧光检测金属有机框架碳点葡萄糖

Keywords

nano-compositefluorescence detectionmetal-organic frameworkcarbon dotsglucose

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