Determination of Distearyl Dimethyl Ammonium Chloride in Cosmetics by High Performance Liquid Chromatography-Evaporative Light Scattering Detector

TANG Juan; DING You-chao; FEI Xiao-qing; WU Bin; QIAN Zhi-juan; CHEN Shan-dan; LI Bai

doi:10.12452/j.fxcsxb.23111102

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Determination of Distearyl Dimethyl Ammonium Chloride in Cosmetics by High Performance Liquid Chromatography-Evaporative Light Scattering Detector

Experimental Techniques and Methods | 更新时间：2024-04-18

- Determination of Distearyl Dimethyl Ammonium Chloride in Cosmetics by High Performance Liquid Chromatography-Evaporative Light Scattering Detector
- Journal of Instrumental Analysis Vol. 43, Issue 4, Pages: 649-653(2024)
- 作者机构：
  
  1.南京海关工业产品检测中心，江苏南京 210019
  2.南京海关动植物与食品检测中心，江苏南京 210019
  3.南京海关轻工产品与儿童用品检测中心，江苏扬州 225009
  4.南京金检检验有限公司，江苏南京 210019
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.23111102
  CLC： O657.7;TQ658
- Published：15 April 2024，
  
  Received：11 November 2023，
  
  Revised：08 January 2024，
- 稿件说明：
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汤娟,丁友超,费晓庆,吴斌,钱志娟,陈山丹,李柏.高效液相色谱-蒸发光散射法测定化妆品中二硬脂基二甲基氯化铵[J].分析测试学报,2024,43(04):649-653.

TANG Juan,DING You-chao,FEI Xiao-qing,WU Bin,QIAN Zhi-juan,CHEN Shan-dan,LI Bai.Determination of Distearyl Dimethyl Ammonium Chloride in Cosmetics by High Performance Liquid Chromatography-Evaporative Light Scattering Detector[J].Journal of Instrumental Analysis,2024,43(04):649-653.
汤娟,丁友超,费晓庆,吴斌,钱志娟,陈山丹,李柏.高效液相色谱-蒸发光散射法测定化妆品中二硬脂基二甲基氯化铵[J].分析测试学报,2024,43(04):649-653. DOI： 10.12452/j.fxcsxb.23111102.

TANG Juan,DING You-chao,FEI Xiao-qing,WU Bin,QIAN Zhi-juan,CHEN Shan-dan,LI Bai.Determination of Distearyl Dimethyl Ammonium Chloride in Cosmetics by High Performance Liquid Chromatography-Evaporative Light Scattering Detector[J].Journal of Instrumental Analysis,2024,43(04):649-653. DOI： 10.12452/j.fxcsxb.23111102.

摘要

建立了测定多种化妆品中二硬脂基二甲基氯化铵（DSDMAC）含量的高效液相色谱-蒸发光散射分析方法。样品经乙腈水溶液（体积比2∶1）超声分散后，加入氯化钠进行振荡提取，取上层有机相分析。采用Acclaim

Surfactant柱（150 mm×4.6 mm，5 μm）分离，以乙腈和100 mmol/L乙酸铵水溶液（pH 5.5）为流动相进行梯度洗脱，外标法定量。结果表明，该类化合物可在18 min内实现有效分离，在10～200 mg/L质量浓度范围内呈良好的线性关系，相关系数（

）为0.999 4，检出限（LOD，

=3）和定量下限（LOQ，

=10）分别为3.27 mg/kg和9.96 mg/kg。在100、500、1 000 mg/kg加标水平下，卸妆油等10种典型空白样品的平均回收率为82.5%~101%，相对标准偏差（RSD，

=6）均不大于6.3%。采用该方法对133个市售样品进行检测，1个乳液样品中DSDMAC的测定值超出法规要求。该方法精密度好，准确度高，适用于各种化妆品中DSDMAC的测定，可为化妆品的质量安全监测提供技术支持。

Abstract

A method for the analysis of distearyl dimethyl ammonium chloride（DSDMAC） in various types of cosmetics was established based on high performance liquid chromatography-evaporative light scattering detector（HPLC-ELSD）. Cosmetics were dispersed with acetonitrile aqueous solution（volume ratio 2∶1） and extracted by sodium chloride with oscillation under the oscillation frequency of 160 r/min for 30 minutes. After extraction，the samples were eluted by gradient elution using acetonitrile and 100 mmol/L ammonium acetate aqueous solution（pH 5.5） as the mobile phases，with an Acclaim

Surfactant column（150 mm×4.6 mm，5 μm）. DSDMAC analysis could be completed within 18 min. The external standard method was applied for quantitative determination. The method showed a good linear relationship for DSDMAC in the concentration range of 10-200 mg/L，with the correlation coefficient（

） as 0.999 4. The limits of detection（LOD） and quantitation（LOQ） were 3.27 mg/kg and 9.96 mg/kg，respectively. The average recoveries in makeup remover oil，hair care essential oil，eye-shadow，pancake，toothpaste，lipstick，emulsion，shampoo，essence water and mouthwash were from 82.5% to 101%，with the relative standard deviations（RSDs，

=6） not exceeded 6.3%. This method was applied to 133 commercial samples，and the content of DSDMAC in one positive emulsion exceeded the regulatory requirement. With good precision and accuracy，the developed method was suitable for the quantitative analysis of DSDMAC in typical kinds of cosmetics，which could provide technical support for the quality and safety monitoring of cosmetics.

关键词

化妆品二硬脂基二甲基氯化铵高效液相色谱蒸发光散射

Keywords

cosmeticsdistearyl dimethyl ammonium chloridehigh performance liquid chromatographyevaporative light scattering

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