In order to assess the migration risk of antioxidants in food contact materials and products,an ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was established for the simultaneous determination of 9 antioxidants migration amounts in food contact materials and products.The separation of 9 antioxidants in the food simulant were performed on a C18 chromatographic column with 1 mmol/L ammonium fluoride-methanol as mobile phase.Under the electrospray ionization positive-negative mode,the antioxidants were detected in a multiple reaction monitoring mode,and quantified by the external standard method.Results indicated that this method exhibited a perfect performance in chromatographic separation.The calibration curves for the 9 antioxidants were linear in the range of 03-6 mg/L with their detection limits of 01 mg/L.The spiked recoveries ranged from 939% to 106% with relative standard deviations of 080%-93%.The method was suitable for the detection of migration amounts of 9 antioxidants in plastic food contact materials and products with the advantages of rapidness,high efficiency and good linear range.