A liquid chromatography-electrospray ionization tandem mass spectrometric (LC-ESI MS/MS) method was developed for the sensitive and selective determination of melamine migration in food contact materials,melamine tableware.The separation was performed on a strong cation exchange column using acetonotrile- 10 mmol/L NH4Ac/HAc (pH=4.0) (40∶60,by volume) as mobile phase at 35 ℃.The determination of melamine in melamine tableware sample was carried out by ESI MS/MS system under the muti reaction monitering mode(MRM).The result indicated that the calibration curves were linear over melamine concentration in the range of 3.00-130.00 μg/L for different simulant solutions with LODs（S/N=3） of 1.00-3.00 μg/L.The average recoveries at three spiked concentration levels of 10.00,50.00,80.00 μg/L were in the range of 98%-104% with relative standard deviations of 3.0%-3.6%.With the advantages of simple sample preparation,high sensitivity and strong anti interference capacity,the method could meet the requirements for determination of melamine migrantion from relevant products.