A analytical method was established for the simultaneous screening and determination of 26 veterinary drugs,including 14 sulfonamides,4 β-agonists，2 fluoroquinolones，3 tetracyclines and 3 organic phosphorus pesticides,in pork by liquid chromatography-quadrupole-time of flight mass spectrometry(HPLC-Q-TOF-MS).The QuEChERS(Quick,Easy,Cheap,Effective,Rugged,and Safe) method was used for sample preparation．The samples were extracted with acidified acetonitrile-methanol(1% acetic acid，10% methanol),and cleaneded up by dispersive solid-phase extraction using C18 dispersant sorbent，then degreased with hexane.The 26 veterinary drugs were separated on an Eclipse Plus C18(3.0 mm×100 mm,1.8 μm) column using water with 0.1% formic acid(A) and methanol(B) as mobile phase by gradient elution in 19 min，and analyzed by MS under ESI positive ionization mode．The quantitation analysis was carried out by extracting peak area with accurate mass．The confirmatory analysis of target compounds was performed with the qualitative fragments．The results showed that the limits of quantitation(LOQ，S/N=10) of 26 target compounds in pork ranged from 0.4 μg/kg to 10 μg/kg．The mean recoveries of 26 veterinary drugs were in the range of 56.7%-106.2%,with RSDs of 7.7%-15.8%.With the advantages of simplicity，fast，efficient,the method was suitable for the analysis of 26 veterinary drugs in pork.