An analytical method was established for the determination of 88 pesticide residues in Pericarpium citri reticulatae by improved QuEChERS pretreatment combined with gas chromatography tandem mass spectrometry(GC-MS/MS) in dynamic multi reaction monitoring mode.Screening and optimizing of sample extraction methods

acetonitrile as extraction solvent

then added with 40 g anhydrous magnesium sulfate and 1.0 g anhydrous sodium acetate

followed by ceramic proton extraction

200 mg PSA

100 mg C18 and 30 mg GCB purification

and finally corrected by matrix matching external standard method.Influences of matrix effect on the quantification accuracy for target compounds in Pericarpium citri reticulatae were significantly weakened.The calibration curves for 88 pesticides exhibited good linearity in a certain concentration range

with their correlation coefficients(r2) not less than 0.996 3.The limits of detection(S/N=3) and the limits of quantification(S/N=10) were 0.001 0-0.050 0 mg/kg and 0.002-0.100 0 mg/kg

respectively.Moreover

the average recoveries at low

medium and high spiked levels ranged from 60.1% to 118% with the relative standard deviations(RSDs

n=6) ranged from 0.30% to 13%.The method was fast

efficient

sensitive and reliable

and was suitable for the rapid screening and routine detection of pesticide residues in Pericarpium citri reticulatae.