碳量子点荧光猝灭法检测药物中的异鼠李素

李海红; 刘荔贞; 冯锋

doi:doi：10.3969/j.issn.1004-4957.2020.04.013

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碳量子点荧光猝灭法检测药物中的异鼠李素

更新时间：2023-04-18

- 碳量子点荧光猝灭法检测药物中的异鼠李素
- Facile Synthesis of Fluorescence Carbon Quantum Dots and Their Application in Detection of Isorhamnetin in Medicines
- 分析测试学报 2020年39卷第4期页码：514-519
- 作者机构：
  
  1. 山西师范大学化学与材料科学学院
  2. 山西大同大学化学与环境工程学院
- 作者简介：
- 基金信息：
  
  山西省教育厅高等学校科技创新项目(2019L0750);大同市重点研发计划项目基金( 2018014)
- DOI：doi：10.3969/j.issn.1004-4957.2020.04.013
  中图分类号：
- 纸质出版：2020
- 稿件说明：
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李海红, 刘荔贞, 冯锋. 碳量子点荧光猝灭法检测药物中的异鼠李素[J]. 分析测试学报, 2020,39(4):514-519.

李海红, 刘荔贞, 冯锋. Facile Synthesis of Fluorescence Carbon Quantum Dots and Their Application in Detection of Isorhamnetin in Medicines[J]. 2020, 39(4): 514-519.
李海红, 刘荔贞, 冯锋. 碳量子点荧光猝灭法检测药物中的异鼠李素[J]. 分析测试学报, 2020,39(4):514-519. DOI： doi：10.3969/j.issn.1004-4957.2020.04.013.

李海红, 刘荔贞, 冯锋. Facile Synthesis of Fluorescence Carbon Quantum Dots and Their Application in Detection of Isorhamnetin in Medicines[J]. 2020, 39(4): 514-519. DOI： doi：10.3969/j.issn.1004-4957.2020.04.013.

摘要

以L-天冬氨酸为碳源，尿素为氮源，采用微波加热法制备荧光碳量子点(CDs)，得到的CDs具有球形结构和单一分散性，平均粒径约为5 nm。红外光谱、X射线光电子能谱、紫外和荧光光谱的表征结果表明，合成的CDs具有较高的荧光稳定性，良好的水溶性和对异鼠李素(ISOR)高的选择性。在优化条件下，ISOR浓度在0.22~180 nmol/L范围内时与CDs荧光猝灭程度(IF0/IF)呈良好的线性关系，检出限(LOD)为1.32 nmol/L，回收率为90.8%~107%。结果表明，该CDs可用于ISOR的快速、高效、灵敏检测。

Abstract

kind of novel fluorescence carbon quantum dots(CDs) were fabricated by microwave heating method using L aspartic acid and urea as the precursors.The obtained CDs exhibited good spherical shapes with an average size about 5 nm.In addition

the CDs were characterized by Fourier transform infared spectroscopy

X-ray photoelectron spectroscopy

ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy.The CDs showed high fluorescence stability

good particle dispersion

excellent water solubility and remarkable selectivity toward isorhamnetin(ISOR).Under the optimized conditions

there was a good relationship between fluorescence quenched degree(IF0/IF) of the CDs and concentration of ISOR in the range of 0.22-180 nmol/L with a limit of detection(LOD) of 1.32 nmol/L.The CDs were successfully applied in the detection of ISOR in ginkgo biloba tablets with recoveries of 90.8%-107%.Results showed that the as synthesized CDs could be used in ISOR detection with rapidness

efficiency and sensitivity.

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