A method based on QuEChERS coupled with high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was developed for the determination of ten fluorescent white agents(FWAs) residues in facial mask.After mixed with water，the sample was extracted with acetonitrile

then added NaCl and MgSO4

cleaned up with C18 and primary secondary amine(PSA).The extracts were centrifuged

concentrated

and diluted with acetonitrile

then analyzed by HPLC-MS/MS.Separation of the FWAs was carried out on a C18 column with 10 mmol/L ammonium acetate and acetonitrile by gradient elution.The compounds were detected in positive/negative ion mode under multi reaction monitoring(MRM) mode.The quantitation was performed by exteral standard method.Results showed that there were good linear relationships for the FWAs in a certain concentration range with correlation coefficients(r2) greater than 0.99.In positive mode

the limits of detection(S/N=3) and the limits of quantitation(S/N=10) were in the ranges of 0.05-1.0 μg/kg and 0.2-3.0 μg/kg

respectively

while in negative mode

they both were 0.1-1.0 mg/kg and 0.3-2.0 mg/kg

respectively.The average recoveries for ten FWAs ranged from 64.4% to 106% with relative standard deviations(RSDs) of 2.6%-8.5%.With the advantages of simple operation and high recovery

the method is suitable for the determination of 10 FWAs in facial mask.