最新刊期
卷 42 ， 期 10 ， 2023
- 摘要：Based on liquid chromatography-high resolution mass spectrometry，this study established target and suspect screening methods of various pesticides and their transformation products for different food matrices through standardized sample extraction methods，low discrimination instrument analysis methods，and the integration of technologies such as omics，machine learning and biotransformation. The experimental results show that the recoveries of different pesticides in various matrices ranged from 80% to 120%. The MS2 of pesticides in samples can balance both detection rate and specificity in data-dependent scanning（DDA） mode with inclusion list. The target screening method is based on the matching of multiple parameters such as retention time（RT），MS1（m/z deviation，isotope profile，addition form，in-source cleavage） and MS2（secondary fragment） in the database，which can identify positive substances with high confidence. Meanwhile，with the help of artificial intelligence（AI） prediction model，eight suspected pesticide transformants were found in chrysanthemum tea. Based on the MS1 matching，these suspected features are further filtered by predicted MS2 and RT. The MS2 characteristics of these transformation products without commercial standard were obtained by in vitro liver microsomes biosynthesis，which confirmed the suspected results. The method realized high throughput and high specificity screening of pesticides and their transformation products，which was suitable for rapid screening of various food substrates.关键词：pesticide;pesticide transformation product;suspect screening;machine learning;biotransformation
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发布时间：2023-10-18 - 摘要：An efficient method was developed to screening 112 illegally added chemical compounds in anti-fatigue health food based on ultra-high performance liquid chromatography quadrupole electrostatic field orbital trap high-resolution mass spectrometry（UPLC-Q-Orbitrap HRMS）. Otherwise，a HRMS database was established through acquiring each chemical compound data by Q-Orbitrap HRMS and analyzing it by Trace Finder software. The samples were prepared by ultrasonic extraction of 90% methanol（containing 0.1% formic acid） and the data were acquired by heat-electrospray ionization（H-ESI） process in the positive ion polarity mode. Through database screening，illegal chemical components were identified. And according to the identification，the sample prepared conditions，chromatographic conditions and MS conditions were optimized，respectively. Then，the verification of the quantitative method of each chemical compound identified was investigated，including its detection limit（LOD），quantitation limit（LOQ） and linear range. The results showed that the LODs and LOQs of 112 compounds were in the range of 0.012 5-0.062 5 mg/kg，and 0.025-0.125 mg/kg ，respectively. The linear ranges were linear within a certain ranges，with correlation coefficients（r2） not less than 0.999. The average recoveries were between 62.0% and 124%，with relative standard deviations（RSDs） of 2.4%-8.9%. Thus，the method could achieve the purpose of high-throughput rapid screening of illegal compounds in health care food. Besides，some suspicious compounds outside the database were found through the full scan mode after the data re-analysis. Furthermore，the identification of suspicious compound was beneficial for discovering new illegal additions. The method has been applied to practical work，and was suitable for the rapid screening of illegal chemical substances in anti-fatigue health products and food.关键词：anti-fatigue;functional food;illegal addition;ultra-high performance liquid chromatography quadrupole electrostatic field orbital trap high-resolution mass spectrometry（UPLC-Q-Orbitrap HRMS）;rapid screening
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发布时间：2023-10-18 - 摘要：An analytical method for detection of 68 chemical risk substances in honey was established based on sugar extraction/ultra high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry technology. The honey extracts were separated by a chromatographic column and then analyzed by quadrupole electrostatic field orbitrap high resolution mass spectrometry. The acquired sample information and the standard information were preliminary screening through the accurate mass number，retention time and isotope distribution ratio comparison. The positive compounds in the initial screening were further confirmed by comparing the secondary fragment ions. This method can accurately screen 68 risk substances in honey within 17 minutes，with the detection limits of 0.03-2.73 μg/kg，the quantification limits of 0.10-9.00 μg/kg，the recoveries of 50.7%-122% and the relative standard deviations（RSDs） of 1.0%-15%. This method was used to detect 32 honey samples，and coumaphos was detected in 12 samples，with the detection concentration ranging from 0.74 to 24.87 µg/kg. This method has high throughput，fast speed，and accurate quantification，and can be used for rapid screening of risk substances in honey.关键词：ultra high performance liquid chromatography（UPLC）;high resolution mass spectrometry;rapid screening;sugar extraction;honey
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发布时间：2023-10-18 - 摘要：QuEChERS combined with ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry（UPLC-QTOF MS） method was developed for the screening of pesticides in peach. Homogeneous fresh peach samples were extracted by acetonitrile containing 1% acetic acid，added with anhydrous sodium acetate and anhydrous magnesium sulfate，purified by PSA and Carb dispersion solid phase extraction powder，and then analyzed using UPLC-QTOF MS under data independent acquisition mode and screened by a self-built pesticides library. Peak identification and spectrum library retrieval were carried out by the UNIFI software. 33 pesticides were detected in 23 fresh peach samples，of which 49% were insecticides，33% were antibacterial agents，and the others were herbicides and plant growth regulators. All samples were detected with one or more pesticides，of which 18 pesticides had national limit standards. The antibacterial carbendazim and flusilazole in 2 fresh peach samples were exceeded the maximum residue limit. This study indicated that UPLC-QTOF MS screening is an effective analytical method to detect pesticides in fruits. Multiresidues of pesticides in peach samples were ubiquitous，thus，more relevant residues monitor and health risk assessment should be conducted in the future.关键词：fresh peach;pesticides;ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry
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发布时间：2023-10-18 - 摘要：A method for the simultaneous determination of 212 pesticide residues in Panax notoginseng by gas chromatography-tandem mass spectrometry（GC-MS/MS） was developed. The samples were extracted by acetonitrile-ethyl acetate（1∶3，by volume），and cleaned up by a FaPEx-BKT50 solid phase extraction cartridge. The analytes were measured on GC-MS/MS，characterized by retention time and characteristic ion pairs，and quantified by external standard method. The results showed that the analytes were linear in the range of 10-200 µg/L，with linear correlation coefficients（r2） more than 0.999.The limits of detection（S/N=3） for the analytes were 0.003-0.02 mg/kg and the limits of quantitation（S/N=10） were 0.01-0.05 mg/kg. At the spiked levels of 0.02，0.04，0.1 mg/kg，the average recoveries of 212 analytes in blank sample were 60.0%-121% with relative standard deviations（RSDs） of 0.90%-31%. The method is simple，sensitive and stable，and all the technical parameters meet the requirements of the domestic and international standards for pesticide residue monitoring，and can be applied to the determination of trace pesticide residues in Panax notoginseng.关键词：gas chromatography-tandem mass spectrometry（GC-MS/MS）;Panax notoginseng;multi-pesticide residues
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发布时间：2023-10-18 - 摘要：This study used ultra-high performance liquid chromatography-quadrupole-orbitrap high-resolution mass spectrometry（UHPLC-Q/Orbitrap HRMS） technology to analyze 41 batches of Ganqingqinglan samples from three regions in Tibet. Compound Discoverer 3.2 software was utilized to identify the chemical components，and differential compounds between different regions were screened through multivariate statistical analysis. A total of 73 compounds were identified in the Ganqingqinglan samples，including 41 flavonoids，15 organic acids，8 amino acids，and 9 other compounds. Through multivariate statistical analysis，11 differential compounds were found between samples from Shannan City（SN） and Lhasa City（LS），18 differential compounds between SN and Qamdo City（CD），and 21 differential compounds between LS and CD（VIP>1，P<0.05）. The majority of differential compounds were flavonoids and organic acids. Chlorogenic acid exhibited the largest difference among the three groups，with the highest content found in the CD group（approximately 11.85 mg/g），followed by the LS group（approximately 7.85 mg/g），and the lowest content in the SN group（approximately 5.30 mg/g）. This correlated with the leaf quantity and powder color of the Ganqingqinglan samples. Considering the topography and climate of each region，it is speculated that sunlight duration and diurnal temperature range have an influence on the chemical composition of Ganqingqinglan. In conclusion，geographical environmental differences are believed to have an impact on the characteristics and chemical composition of Ganqingqinglan. These research findings provide a theoretical basis for quality control and subsequent rational development and utilization of Ganqingqinglan.关键词：UHPLC-Q/Orbitrap HRMS technology;Ganqingqinglan;multivariate statistical analysis;differential components
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发布时间：2023-10-18 - 摘要：An analytical method for the determination of acrylamide in honey samples by modified QuEChERS using ultra high performance liquid chromatography-tandem mass spectrometry was established. After dissolved by water，honey samples was extracted by acetonitrile，and then the extracted supernatant was cleaned by matrix dispersion solid phase extraction. The target was separated by ZORBAX RRHD Eclipse Plus C18 column（3.0 mm×150 mm，1.8 μm） using 0.1% formic acid solution and methanol as mobile phase by gradient elution，and analyzed in positive electrospray ionization mode by multiple reaction monitoring（MRM） mode. Acrylamide was quantified by internal standard method. The analyte showed a good relationship in concentration range of 2.0-500 ng/mL，with a correlation coefficient（r2） of 0.999 7. The limits of detection and quantitation of the method was 0.42 μg/kg and 1.38 μg/kg，respectively. Average recoveries of acrylamide at low，medium and high spiked levels in honey matrices were 89.2%-96.3%，and relative standard deviations（RSDs，n=6） were 2.2%-4.2%. The proposed method was applied for the determination of acrylamide in 30 honey samples，and all samples showed positive results. The acrylamide contents of 30 honey samples ranged from 2.5 to 40.4 μg/kg. This method was suitable for analysis of acrylamide in honey samples with the advantages of simplicity，rapidity，high sensitivity and accuracy.关键词：QuEChERS;ultra high performance liquid chromatography-tandem mass spectrometry;honey;acrylamide
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发布时间：2023-10-18 - 摘要：In this paper，a screening and quantitative method for 15 kinds of 153 veterinary drugs in raw milk matrix was established by one-step QuEChERS combined with liquid chromatography quadrupole electrostatic field orbital trap high resolution mass spectrometry（LC-Q Orbitrap HRMS）. Raw milk samples were added with 6 mL of Na2EDTA-McIlvine buffer，extracted with acetonitrile acidified with 1%（by volume） acetic acid，purified with 30 mg PSA and 90 mg C18，separated on an Agilent Eclipse plus C18 column using 0.1% formic acid aqueous solution and acetonitrile as mobile phase，and detected in full MS/dd-MS2 positive ion scanning mode. All kinds of veterinary drugs had good linearities in the corresponding concentration ranges，and the correlation coefficient（r2） were above 0.99. The limits of screening（SDL） of all veterinary drugs were in the range of 0.1-20 μg/kg，and the limits of quantitation（LOQ） were in the range of 0.1-20 μg/kg. The recoveries were verified at three spiked levels of 1-，2- and 10- times LOQ（n=6）. The recoveries of target veterinary drugs at three spiked levels ranged from 70% to 120%，and the relative standard deviations（RSDs）≤20% accounted for 92.8%，94.1% and 94.8%，respectively. This method has the advantages of simple sample processing，short time consumption，and high sensitivity，making it suitable for rapid screening and quantification of multiple types of veterinary drugs in raw milk.关键词：raw milk;liquid chromatography quadrupole electrostatic field orbital trap high resolution mass spectrometry（LC-Q Orbitrap HRMS）;veterinary drugs
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发布时间：2023-10-18 - 摘要：To establish a method for the determination of prohibited drugs in poultry eggs by ultra performance liquid chromatography-tandem triple quadrupole mass spectrometry（UPLC-QqQ-MS），samples were extracted and purified using QuEChERS method. The drugs were extracted with 0.2% formic acid-acetonitrile solution（3∶1，by volume），and 25 mg of Na2EDTA was added to chelate the metal ions in the matrix，and the separation was performed on an ACQUITY UPLC HSS T3 column（2.1 mm×100 mm，1.8 μm） after cleanup with EMR-lipid packing. The separation was carried out by gradient separation with 0.1% formic acid aqueous solution-methanol as mobile phase in positive ion mode and water-acetonitrile as mobile phase in negative ion mode，which was scanned by multi-reaction monitoring（MRM） mode and quantified by the standard curve internal standard method. The results showed that target compounds obtained good linear relationship in their respective mass concentration ranges，with correlation coefficients（r2） not less than 0.99. The limits of detection（LODs） and the limits of quantitations（LOQs） for the 90 compounds were determined to be 0.05-1 μg/kg and 0.1-3 μg/kg，respectively. Average recoveries of these compounds in eggs were 60.8%-111%，and the relative standard deviations were 1.6%-18%，which met the requirements of multiple veterinary drug residues. A total of 7 prohibited drugs were detected in 106 samples. This method can be used for the high-throughput rapid detection of prohibited drug residues in poultry eggs with a simple，accurate and low-cost procedure.关键词：QuEChERS;ultra performance liquid chromatography-tandem mass spectrometry;prohibited drugs;poultry eggs
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发布时间：2023-10-18 - 摘要：A gas chromatography-exactive orbitrap mass spectrometry（GC-Exactive Orbitrap MS） method was established to simultaneous determination of 71 kinds of pesticide residues in milk. The sample was extracted with 1.0% formic acid-acetonitrile solution and pretreated with modified QuEChERS method. The purified liquid was dried，re-dissolved，measured by Full MS mode of GC-Exactive Orbitrap MS and quantified by matrix matching internal standard method. The 71 kinds of pesticides showed good linear relationships within the respective concentration ranges，and the correlation coefficients（r） were not less than 0.99. The deviations for each accurate mass number were not more than 2.55×10-6，and the detection limits were 1.0-2.0 μg/kg. The average recoveries were 59.6%-117% at 0.01，0.02，0.10 mg/kg spiked concentrations，with the relative standard deviations（RSDs） of 1.9%-13%. 4，4'-DDE was detected in two of ultra-high temperature sterilized milk，and the detected values were all lower than LOQ. The method is simple and efficient，which is suitable for the analysis of 71 kinds of pesticide residues in milk.关键词：pesticides;milk;QuEChERS;gas chromatography-exactive orbitrap mass spectrometry
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发布时间：2023-10-18 - 摘要：An ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry method was developed for rapid screening of 69 veterinary drugs belonging to four classes（β-agonists，sulfonamides，quinolones and tetracyclines） in milk. The extraction was performed using acetonitrile solution containing 0.5% formic acid，and the purification was carried out by liquid-liquid extraction using n-hexane for defatting. An ACQUITY UPLC BEH C18 column was used for chromatographic separation，and gradient elution was performed using 0.1% formic acid and methanol-acetonitrile（2∶8） containing 0.1% formic acid as the mobile phases. The electrospray ionization was used in positive ion mode for full scan and data-dependent acquisition mode（DDA） detection. Efficient separation of 69 veterinary drugs can be achieved within 10 min. The limits of quantification（LOQs） of 69 veterinary drugs in milk was 10 μg·kg-1. The average recoveries was 59.0%-120% with relative standard deviations（RSDs） of 0.80%-13% at three spiked levels（10，50 and 100 μg·kg-1）. This method is simple and efficient，and can be used for the rapid screening of 69 veterinary drugs in milk.关键词：milk;ultra-high performance liquid chromatography;time-of-flight mass spectrometry;veterinary drug residues;rapid screening
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发布时间：2023-10-18 - 摘要：A comprehensive high-throughput screening and quantification method for hormones was established based on ultrahigh performance liquid chromatography-quadrupole-time of flight mass spectrometry（UPLC-Q-TOF MS）. A database for qualitative screening of 51 hormones was established using information dependent acquisition（IDA） mode. After precipitation of protein in milk samples by acetonitrile，the milk samples were purified using zirconia coated silica gel sorbent（Z-Sep）. Separation was performed on Waters Acquity BEH C18 column（100 mm × 2.1 mm，1.7 μm） with gradient elution by UPLC-Q-TOF MS and quantified using matrix matching curve external standard method. The method showed good linearity in the range of 0.10-500 μg/L，with correlation coefficients（r2） greater than 0.99. The limits of detection（LODs） and limits of quantitation（LOQs） were in the range of 0.03-1.67 μg/kg and 0.10-5.00 μg/kg，respectively. The recoveries is 44.6%-120% with relative standard deviations of 0.90%-20%. Twenty milk samples were determined using this method，of which 19 samples were detected for progesterone，with content ranged from 0.80 to 4.51 µg/kg，one sample had trace amounts of cortisol detected at 0.62 µg/kg，and no other hormones were detected. This method has good linearity，sensitivity，accuracy，and precision，and can be used for simultaneous qualitative and quantitative analysis of multiple hormones.关键词：hormones;milk;UPLC-Q-TOF MS;QuEChERS
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发布时间：2023-10-18 - 摘要：A method of QuEChERS/gas chromatography-triple quadrupole mass spectrometry was established for the simultaneous determination of 35 pesticide residues in green tea. The samples were brewed with water at 85 ℃，then extracted with acetonitrile after cooling down. After purified with 200 mg PSA，200 mg C18 and 50 mg GCB，the analytes were separated on an Agilent HP-5MS capillary column（30 m×0.25 mm×0.25 μm）. The analysis was performed in electron impaction source under multi-reaction monitoring mode，and quantified by matrix-matched standard curve and external standard method. There were good linear relationships for 35 pesticides in concentration range of 10-1 000 µg/L，with their correlation coefficients（r2） larger than 0.99. The limits of detection and limits of quantitation were 1-5 µg/kg and 5-15 µg/kg，respectively. The average recoveries for 35 pesticides in green tea at the spiked levels of 20，40 and 200 µg/kg ranged from 70.3% to 112%，with relative standard deviations of 1.6% -12%. 30 commercially available green tea were detected by the proposed method，and 6 pesticides were found in 4 samples. The method is simple，rapid，sensitive，and accurate，and could be adapted for daily analysis and planed monitoring of 35 pesticide residues in green tea samples.关键词：gas chromatography-triple quadrupole mass spectrometry;green tea;pesticide residue;QuEChERS
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发布时间：2023-10-18 - 摘要：An analytical method was established for the determination of 25 diuretics in animal-derived foods by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry（UPLC-QE-Orbitrap HRMS）. The animal meat samples were extracted with 80% acetonitrile aqueous solution，while egg and milk samples were extracted with acetonitrile. The extracts were purified through a PRiME HLB solid-phase extraction column and separated on an HSS T3 column，gradient elution with 0.1% formic acid aqueous solution and acetonitrile，simultaneous detection by Q-Exactive Orbitrap with Full MS/dd-ms2 mode，under HESI positive and negative ion mode. The results showed that the linearities were good in the range of 10-200 ng/mL for tolvaptan，ethacrynic acid，amiloride，triamterene，methyclothiazide and xylazine，and 5-100 ng/mL for other diuretics，with corralation coefficient（r2） greater than 0.99. The detection limits were in the range of 5-10 μg/kg，the method recoveries were 63.0%-116% and the relative standard deviations（n=6） were 0.80%-14% . The method is simple and practical，and can achieve rapid screening and accurate quantification of diuretics in animal-derived foods，which could provide effective technical support for the detection of diuretics in animal-derived foods.关键词：ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry（UPLC-QE-Orbitrap HRMS）;animal-derived foods;diuretics
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发布时间：2023-10-18 - 摘要：A confirmatory test for the simultaneous determination of sulfonamides，tetracyclines，and quinolones in urine totalling 45 antibiotics by ultra-high performance liquid chromatography-tandem mass spectrometry（UPLC-MS/MS） was developed. The urine samples were extracted and then cleaned up by an HLB solid phase extraction column（200 mg/6 mL），and the separation of the target was performed on a ThermoAccucore RP-MS column（100 mm×2.1 mm，2.6 µm） using acetonitrile-0.02% formic acid aqueous solution with gradient separation elution，detected in positive ion scanning mode（ESI+） in multiple selected reaction monitoring（SRM） and quantified by external standard method. The recoveries of a total of 45 target compounds from three classes of antibiotics at three spiked levels（2.0，5.0 and 10.0 μg/L） were in the range of 78.6 %-114% with the RSDs in the range of 0.60%-18%，and the limits of detection（LODs） and the limits of quantification（LOQs） of the method were in the range of 0.1-0.5 μg/L and 0.3-1 μg/L，respectively. The developed method was applied to 280 urine samples for the detection of antibiotics，none of which detected antibiotics residues in excess of limit. The results showed that the established method was highly precise and accurate，simple and convenient，and included commonly used antibiotic species，which can support the screening antibiotic residues in urine.关键词：antibiotic;urine;ultra-high performance liquid chromatography-tandem mass spectrometry;sulfonamides;quinolones;tetracyclines
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发布时间：2023-10-18 - 摘要：An analytical method for the simultaneous detection of 21 pyrrolizidine alkaloids（PAs） in tea was established by high performance liquid chromatography-tandem mass spectrometry. The samples were extracted by 0.05 mol/L sulfuric acid，cleaned by solid phase extraction，separated by Phenomenex Kinetex F5 column（150 mm×3.0 mm×2.6 μm），and gradient eluted with methanol-0.1% formic acid water as mobile phase. The analytes were detected in multiple reaction monitoring（MRM） mode with positive ion mode scanning，quantified by matrix matching standard curve external standard method. The results showed that 21 PAs showed a good linear relationship in their respective concentration ranges（r2≥0.995 0）. The detection limits（LODs） of the method was 0.3-1.0 μg/kg. Under the three spiked levels of low，medium and high，the recoveries（n=6） were between 72.1%-108%，and the relative standard deviations（RSDs，n=6） were 2.0%-9.8%. This method was used for the detection of commercially available tea samples，and PAs were detected in 5 samples with total content of 1.8-85 μg/kg. The established method is efficient and stable，and can simultaneously detect 21 pyrrolizidine alkaloids.关键词：pyrrolizidine alkaloids;tea;high performance liquid chromatography-tandem mass spectrometry
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发布时间：2023-10-18
Scientific Papers
- 摘要：The chemically hazardous substances in plant-derived foods threaten people’s life and health. At present，the chemical hazards in plant-derived foods have the characteristics of large categories，low residues，and unknown potential risks，which lead to difficult to detect. Therefore，it is significant to develop high-throughput and high-sensitive detection techniques of chemically hazardous substances in plant-derived foods. Chromatography-mass spectrometry techniques have many advantages，such as high sensitivity，high selectivity，and high throughput. Therefore，chromatography-mass spectrometry techniques have been widely used in the field of chemically hazardous substances detection in the plant-derived foods. This paper summarized the research progress of detection techniques of chemically hazardous substances in plant-derived foods based on chromatography-mass spectrometry，including the types and status quo of major chemically hazardous substances in plant-derived foods，the types and the development trend of the related sample preparation methods，and the research status quo of detection techniques based on chromatography-mass spectrometry. The advantage and existing problems of different detection techniques were discussed，and the development trend of detection techniques applied in the field of the chemically hazardous substances detection was prospected to providing a new reference for the related research of chromatography-mass spectrometry in the detection of chemically hazardous substances in plant-derived foods.关键词：plant-derived foods;chromatography-mass spectrometry;chemically hazardous substances;high-throughput
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发布时间：2023-10-18 - 摘要：Due to the complexity of plant-derived food matrix，the variety of pesticide residues，and the strict standards for the pesticide residue limits，it is of great significance to establish a high-throughput and rapid multi-pesticide residues detection technique in plant-derived food samples. Gas chromatography-mass spectrometry（GC-MS） is one of the most widely used technologies in the field of multi-pesticide residues high-throughput detection. However，there are still many problems in the high-throughput detection of multi-pesticide residues in plant-derived food samples. Now，scientific researchers at home and abroad have done many researches. The key to improve the detection ability is to develop the sample pretreatment technology based on the existing equipment and high-throughput resolution algorithms of complex signals. This paper summarizes the high-throughput detection technology in recent years of multi-pesticide residues in plant-derived food samples based on GC-MS developed from domestic and abroad from the two aspects：new sample pretreatment technology for the extraction of different pesticide residues and high-throughput resolution algorithms of complex signal based on‘mathematical separation’. In addition，the relevant suggestions were put forward for the existing problems. We would like to provide references for the high-throughput and rapid detection of multi-pesticide residues in food samples.关键词：gas chromatography-mass spectrometry（GC-MS）;multi-pesticide residues;high-throughput detection;sample pretreatment;chemometrics
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发布时间：2023-10-18 - 摘要：Food safety is related to people’s health of the broad masses. In order to screen the chemical hazardsmore accurately and efficiently in food，it is extremely important to conduct rapid and high-throughput non-targeted analysis of food. In non-targeted analysis，sample pretreatment is required to eliminate the effects of complex matrix in food，and to efficiently recover and enrich chemical hazards，so the development of appropriate sample pretreatment methods and materials is particularly critical. Recently，new nanomaterials such as metal-organic frameworks，covalent organic frameworks and magnetic nanomaterials play important roles in sample pretreatment. This paper mainly introduces the sample pretreatment methods for food safety non-targeted analysis，the application of nanomaterials in sample pretreatment，and the application of sample pretreatment in non-targeted analysis in recent years. And its development trend is prospected.关键词：food safety;non-targeted analysis;sample pretreatment;emerging nanomaterials
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发布时间：2023-10-18 - 摘要：High resolution mass spectrometry combined with traditional data analysis methods is often used to identify the quality of saffron. However，the traditional data analysis algorithm sometimes has low accuracy and poor model fitting effect，resulting in high false positive rate and false negative rate of discrimination results，and it is difficult to accurately identify the quality of saffron. Deep learning algorithm can automatically extract the hidden feature information in the data，and combine with high resolution mass spectrometry technology to accurately identify the quality of saffron. This paper briefly summarizes research progresses of deep learning algorithms in processing high resolution mass spectrometry metabolomics data. On this basis，applications of deep learning algorithm in saffron quality identification were summarized，and the feasibility of combining high resolution mass spectrometry with deep learning algorithm was further discussed.关键词：deep learning;saffron;high resolution mass spectrometry;feature extraction;quality identification
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发布时间：2023-10-18
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