最新刊期
卷 31 ， 期 6 ， 2012
- 摘要：In Britton-Robinson buffer of pH 2.5-3.5，famciclovir(FCV)could react with palladium(Ⅱ) to form 1∶1 anionic chelates.The chelates react further with chrome azurol S(CAS) to form the ion-association complexes,which could result in the great enhancement of resonance Rayleigh scattering(RRS) intensities and a new RRS spectra appearing.The maximum RRS wavelength locates at 367 nm.Under the optimum conditions，the intensities of RRS are proportional to concentration of FCV in the range of 0.02-2.4 mg/L，with a detection limit of 3.6 μg/L.The reaction conditions of the system and effect of coexisting substances were investigated.The softwares of Gaussview 3.07 and Gaussian 03W at a B3LYP/6-31G(base group)level based on the density functional theory(DFT) were used to calculate the charge distribution of FCV.The reaction mechanism and the reasons for RRS enhancement of the system were investigated.The method was simple,rapid and sensitive ,and was applied in the determination of FCV in capsule and urine samples with satisfactorily result.关键词：resonance Rayleigh scattering(RRS);famciclovir;palladium(Ⅱ);chrome azurol S
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- 2
发布时间： - 摘要：A new method for the determination of 3 aquaculture disinfectants in aquatic products using hydrophilic interaction liquid chromatography-tandem mass spectrometry（LC-MS/MS） was established.The homogenized sample was extracted with acetonitrile-5% ammonia hydroxide（30∶70，by volume）.Separation of analytes was performed using a SeQuant ZIC-HILIC hydrophilic interaction column by gradient elution after solid-phase extraction（SPE） purification.The qualitative and quantitative analyses of 3 aquaculture disinfectants were operated by electrospray ionization mass spectrometry under the negative mode using multiple reaction monitoring（MRM）.Acetonitrile and water with 0.1% formic acid and 10 mmol/L ammonium acetate were used as the mobile phase.The calibration curves were linear in the range of 0.042-2.4 mg/L with correlation coefficients more than 0.99.The average recoveries at three spiked concentration levels varied from 68% to 96% with relative standard deviations（RSDs） of 5.9%-10.9%.The limit of detection（LOD，S/N≥3） and limit of quantitation（LOQ，S/N≥10） were 0.015 mg/kg and 0.05 mg/kg，respectively.The real sample tests showed that the method was suitable for the determination of aquaculture disinfectants in aquatic products.关键词：hydrophilic interaction;liquid chromatography-tandem mass spectrometry（LC-MS/MS）;aquaculture disinfectants;triclosan;dichloroisocyanurate;trichloroisocyanurate;aquatic products
- 3395
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- 1286
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- 4
发布时间： - 摘要：The interactions of an anticancer drug,camptothecin with lysozyme and catalase were investigated by the combination of several spectroscopic techniques,including UV-Vis absorption,IR and fluorescence spectra.The results showed that camptothecin could form groundstate complexes with these two proteins and induce the quenching of the intrinsic fluorescence of proteins.The binding constants and the numbers of binding site of camptothecin interacting with lysozyme and catalase at different temperatures were calculated.Their main binding forces were electrostatic interaction and hydrophobic interaction.The distances between camptothecin and tryptophan residues in lysozyme and catalase were determined.Camptothecin showed a higher binding affinity on catalase than it had on lysozyme,as it interacted not only with tryptophan residue,but also with tyrosine residue and heme in catalase.The results also showed that the presence of camptothecin could induce the conformational variation of proteins with a decrease in α-helix secondary structure.
- 1812
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- 944
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- 3
发布时间： - 摘要：A method was established for the separation and determination of chlorinated paraffin（CPs） and polychlorinated biphenyls（PCBs） in sediment.CPs and PCBs were firstly extracted with dichloromethane from sediment，then CPs were separated from PCB via a cleanup procedure with complex Florisil/Silica column.The fraction containing PCBs was eluted with 80 mL hexane，followed by the elution of fraction containing CPs with 60 mL dichloromethane.CPs were determined by GC-ECNCI-LRMS under selective ion monitoring mode and PCBs were analyzed by GC-EI-MS，and quantified by the internal standard method.The procedure of sample pretreatment，amount of dispersant and instrument conditions were also optimized.The result indicated that recoveries of technical mixture of CP52 and 22 PCB standards in spiked matrix ranged from 86% to 99%，with RSDs less than 10%.The method detection limits for short-chain chlorinated paraffin（SCCPs） and medium-chain chlorinated paraffin（MCCPs） were in the ranges of 0.144-3.47 ng/g and 0.530-2.24 ng/g，respectively.The method was applied in the determination of CPs and PCBs in six sediments from Dongjiang River.The concentrations of SCCPs，MCCPs and PCBs were in the ranges of 0.245-1.58 μg/g，0.538-1.83 μg/g and 1-100 ng/g，respectively.Therefore,the method was rapid，sensitive and accurate，and was suitable for the reliable investigation of CPs and PCBs in sediment as well as in soil samples.关键词：GC-MS;short-chain chlorinated paraffin（SCCPs）;medium-chain chlorinated paraffin（MCCPs）;polychlorinated biphenyls（PCBs）;sediment
- 2507
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- 1111
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- 10
发布时间： - 摘要：A method for the analysis of 32 industrial dyes in seasoning paste was developed by ultra performance liquid chromatography-tandem mass spectrometry（UPLC-MS/MS） combined with gel permeation chromatography（GPC） purification.The homogenized sample was extracted with acetonitrile，and then purified by GPC.The targeted compounds were detected by MS/MS system with eletrospray ionization（ESI） under multiple reaction monitoring（MRM） mode.The result indicated that the limits of quantitation（LOQs） of 32 dyes were in the range of 0.2-5 μg/kg.The linear correlation coefficients of 32 dyes were more than 0.994.The average recoveries ranged from 53% to 115% with RSDs of 3.9%-22.4%.This method was suitable for the identification and quantification of multi-component dyes in seasoning paste due to its simplicity，good purification and high sensitivity.关键词：seasoning paste;industrial dyes;GPC;UPLC-MS/MS
- 2835
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- 1069
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- 14
发布时间： - 摘要：As a powerful tool for the analysis of high pure metal and semiconductor，glow discharge mass spectrometry(GDMS) has been extended applied in China.The primary theory and application of GDMS were simply introduced and the instrumental conditions，measurement repeatability and series certified reference materials with different metallic matrix were researched in detail.The measured repeatabilities of analysis results were in the range of 1%-5% for the impurities which the contents were about 1 mg/kg. The series of certified reference materials of steel，copper，including SRM1761a,SRM1762a，SRM1763a，SRM1764a，SRM1765，SRM1766，SRM1767，SRM1767，SRM1112-SRMC1117 and SRM1256b purchased from National Institute of Standards and technology(NIST) of USA，were investigated and the results were compared.It was found that the same correction factors could be used in the measurement of impurities with similar matrix in a wide range of contents under the same measurement conditions.The correlation coefficients of series results were more than 0.999.It was found that there were obvious matrix effects in the measurements of samples with different matrixes.The routine instrumental values of some relative sensitivity factors(RSFs)，especially for the elements of lighter mass number，were not suitable for the quantitative analysis,but it is enough for the semi-quantitative analysis because the differences were no more than double of the RSFs.The result indicated that the correction of RSFs was the key technique for the measurement traceability through the research of the quantitative analysis by GDMS spectrometry.关键词：glow discharge mass spectrometry(GDMS);relative sensitivity factors;quantitative analysis;matrix effect
- 2163
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- 1281
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- 6
发布时间： - 摘要：A method for the analysis of strobane residues in meat,beef,mutton,chicken,chinese bacon and dry pork was developed using gas chromatography-negative chemical ionization mass spectrometry(GC-NCI/MS),based on gel permeation chromatography(GPC) purification.The homogenized sample was extracted with n hexane，then cleaned by GPC with ethyl acetate-cyclohexane solution(1∶1) as mobile phase．The targeted compounds were detected under selected ion monitoring(SIM)mode and quantified by the external standard method.The high correlation coefficents(r=0.999 7)of strobane were obtained within a concentration range of 0.01-2.0 mg/L .The LOQ of strobane was 10 μg/kg.In the six matrixes mentioned above,the average recoveries of strobane at spiked concentration of 10.0-50.0 μg/kg ranged from 80% to 98%,with RSDs(n=8) of 2.1%-8.7%.This method was suitable for the identification and quantification of strobane residues in various meat and meat products.关键词：strobane;gas chromatography-negative chemical ionization mass spectrometry(GC-NCI/MS);gel permeation chromatography(GPC);meat and meat products
- 1954
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- 1005
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- 0
发布时间： - 摘要：Effects of DNA damage induced by Chinese herbal medicine were studied by differential pulse voltammetric(DPV) method.The voltammeitric behaviour of 8-hydorxy-2-deoxyano-sine(8-OHdG) in the phosphate buffer(pH 5.0) was investigated at a glassy carbon electrode by cyclic voltammetry(CV) and DPV.A well-defined oxidation peak of 8-OHdG at +0.5 V was found，and its current intensity was proportional to concentration of 8.OHdG in the range of 1.0×10-6-7.1×10-4 mol/L.The regression equation was Ip(μA)=0.004 3c(mol/L)+4×10-8(r=0.999 8) and the detection limit(S/N=3) was 3.5×10-7 mol/L.The method was applied in analysis of the levels of 8-OHdG in the calf thymus DNA(ctDNA) exposed to concentration of 40 g/L of glycyrrhiza，cherokee rose，eucommia ulmoides，pinellia，nux vomica extract for 2 h，respectively，and the blood of Kunming mice exposed to low and high concentration of nux vomica extract by mouth injection for 30 consecutive days.The results showed that glycyrrhiza，cherokee rose，eucommia ulmoides，pinellia extract could not cause ctDNA oxidative damage，and nux vomica extract can cause DNA oxidative damage to the formation of 8-OHdG in the average level of (3.2±0.2)μmol/L.The average levels of 8-OHdG were (2.0 ± 0.1) μmol/L and (5.3 ± 0.3) μmol/L in the blood after a long-term administration of low concentration and high concentration of nux vomica extracts of Kunming mice，respectively.The study indicated that nux vomica contained the potential genotoxicity.关键词：differential pulse voltammetry(DPV);Chinese herbal medicine;DNA damage;8-hydorxy-2-deoxyano-sine(8-OHdG);genotoxicity
- 2390
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- 1084
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- 0
发布时间： - 摘要：A rapid method for the determination of glyceryltrioleate was developed by using screen-printed electrode（SPE） modified with lipase as an electrochemical biosensor.Cyclic voltammetry(CV) and chronocoulometry(CC) were applied to characterize the behavior of glyceryltrioleate on the surface of the lipase-modified SPE.The optimal conditions of glyceryltrioleate determination were investigated.A linear response to glyceryltrioleate in the concentration ranges of 001-5 g?L-1 with a detection limit of 2.5 mg?L-1 for CV,and 0.001-5.50 g?L-1 with a detection limit of 0.2 mg?L-1 for CC were obtained.The method was used in the determination of 6 sunflower seed oil samples with spiked recoveries of 94%-105%.关键词：Screen-printed electrode;lipase;glyceryltrioleate
- 2696
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- 1082
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- 1
发布时间： - 摘要：A high performance liquid chromatography with tunable ultraviolet method（HPLC-UV） was developed for the quantification of thiocyanate in milk products and raw materials.Samples were purified and extracted by Oasis WAX SPEs followed by protein precipitation with acetic acid.The purified solution was separated on a symmetry C18 column using methanol-phosphatic solution（containing ion pair reagent） as mobile phase,and analyzed by the internal standard method at a detection wavelength of 231 nm.Under the optimal conditions,the linear range for thiocyanate was in the range of 0.2-50 mg/L with correlation coefficient more than 0.999.The limit of detection for thiocyanate was 0.05 mg/kg,and the limit of quantitation（LOQ） was 0.15 mg/kg.The recoveries at spiked concentration levels of 1,5,25 mg/kg were in the range of 77%-104%.With the advantages of excellent reproducibility,high sensitivity and good practicability,this method could be used as a routine detection in practice.关键词：thiocyanate;SPE extract;HPLC;ultraviolet detection;milk product
- 2017
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- 1132
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- 1
发布时间： - 摘要：An electro-deposition method was adopted to prepare gold-capped pencil graphite surface using pencil graphite electrode(PGE).By chemical bonding of Au-S,L-cysteine(L-Cys) can be stably immobilized onto the surface of gold,followed by an assembling with acridine orange(AO) via the electrostatic interaction between AO and L-cysteine to obtain an AO/L-Cys/Au/PGE multilayer membrane.The prepared multilayer membrane was connected between the terminal joints of the working electrode and the counter electrode,together with a reference electrode,to construct a novel system.The whole multilayer membrane fabrication process was characterized by cyclic voltammetry and electrochemical impedance spectroscopy.The interaction of AO and the subsequent introduction of bovine serum albumin(BSA) resulted in a significant change of zero current potential(ΔEzcp) utilizing zero current potentiometry,thus the electrochemical quantification of BSA could thus be realized.The results showed that ΔEzcp and logarithmic of BSA concentration was linear in a wide concentration range of 1.0×10-9-1.0×10-5 mol/L(r=0.997 0),and the detection limit was 1.41×10-11 mol/L.The multilayer membrane exhibited good selectivety and reproducibility,and was applicable for the determiantion of other proteins.关键词：zero current potentiometry;bovine serum albumin;pencil graphite electrode;self-assembled multilayer membrane
- 2068
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- 1002
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- 2
发布时间： - 摘要：Based on the basic principles of biomineralization,calcium carbonate was induced by egg white protein（EWP） in the dialysis bag compartment under biomimetic conditions.The different morphology and polymorphy of calcium carbonate were characterized by SEM and FT-IR spectra.The results showed that calcium carbonates were all vaterite under different conditions except in the distilled water.Dialysis bag limited not only the movement of protein,but also the movement of the coordination compound of Ca2+- egg white protein,and provided a solid foundation to prepare a special morphology of calcium carbonate.关键词：biomimetic synthesis;calcium carbonate;egg white protein（EWP）;dialysis bag
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- 1076
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- 0
发布时间： - 摘要：An analytical method was developed for the determination of sulbactam in milk using hydrophilic interaction chromatography tandem mass spectrometry（HILIC-MS/MS）.The samples were extracted with 0.2% acetic acid solution，then purified and enriched with an HLB solid-phase extraction（SPE）cartridge.The separation of sulbactam was carried out on an Acquity UPLC BEH HILIC column using ammonium formate - acetonitrile as mobile phase．The quantitation analysis of target compound was performed under the multiple reaction monitoring（MRM） mode by the external standard method.A good linear relationship was obtained between peak area and concentrations of sulbactam in the range of 1-100 μg/L，with correlation coefficients more than 0.99 and limit of quantitation（LOQ） of 1.0 μg/kg．The recoveries at spiked levels of 1.0-50.0 μg/kg ranged from 82% to 102% with relative standard deviations of 1.6%-47%.With the advantages of convenience，sensitivity，good recovery and repeatability，the method was suitable for the detection of sulbactam in milk．关键词：sulbactam;hydrophilic interaction chromatography tandem mass spectrometry（HILIC-MS/MS）;milk
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- 7
发布时间： - 摘要：In this paper，Tenax-TA tubes were used for air sampling with a small volume air sampler，and a gas chromatography-mass spectrometer(GC-MS) equipped with thermal desorber was adopted to analyze 4 simulant warfare agents，including 1，2-dichloroethane，N，N-dimethylacetamide，trimethyl phosphate and dimethyl methylphosphonate.The results showed that good linearities for four simulant CWAs were obtained in the range of 1-100 ng/tube with correlation coefficients(r2) more than 0.99.The average spiked recoveries were in the range of 82%-112%.The limits of detection(LODs) ranged from 0.13 ng/tube to 0.26 ng/tube，and the relative standard deviations(RSDs) were less than 15%.关键词：thermal desorption;gas chromatography-mass spectrometry(GC-MS);chemical warfare agents(CWAs);air;simulants
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- 1006
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- 3
发布时间： - 摘要：A new type of solid phase extraction column(Bond Elut ENV)was used for the rapid determination of benzo［a］pyrene in edible vegetable oil.And a solid phase extraction purification and high performance liquid chromatography/fluorescence detection method was developed for the determination of benzo［a］pyrene in edible vegetable oil.Samples were dissolved in n-hexane and then purified by solid phase extraction.Chromatographic analysis was performed on a SUPELCOSILTM LC-PAH(25 cm×4.6 mm，5 μm) column using acetonitrile-water (95∶5) as mobile phase.Quantitation analysis was carried out by the external standard method using fluorescence detecter at λex=297 nm and λem=408 nm.The calibration curve was linear over the benzo［a］pyrene concentration in the range of 1.0-50.0 μg/L(r=0.999 6) with detection limit of 0.3 μg/kg.The recoveries ranged from 79% to 102% with relative standard deviations no more than 94%.The method is accurate,practical,simple and fast,and has an extensive application prospect in the determination of benzo［a］pyrene residues in edible vegetable oil.关键词：Bond Elut ENV solid phase extraction column;edible vegetable oil;benzo［a］pyrene;silica gel solid phase extraction column;liquid chromatography with fluorescence detection
- 1905
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- 1104
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- 6
发布时间： - 摘要：A high performance liquid chromatography(HPLC) method was developed for the determination of polyoxin residue in paddy soil and water. The paddy water was adjusted to pH 8.0 with ammonia water，and extracted with acetic ether to remove organic impurities. The water phase was concentrated to constant. The paddy soil was extracted using alkaline mixed with solution of carbinol-water(70∶30)，and concentrated to constant. The above extracts were separated on a C18 hydrophilic stainless steel chromatographic column(AQ-C18,4.6 mm×250 mm,5 μm) and detected with ultraviolet detector(UVD).The quantification analysis of polyoxin was performed by the external standard.The other optimal conditions were as follows:mobile phase:carbinol- water(13∶87);flow rate:1.0 mL/min for first 0-8 min，and 0.3 mL/min for the next 8-16 min，column temperature:30 ℃，detection wavelength:272 nm. Under the optimal conditions，the calibration curve was linear between peak area and polyoxin concentration in the range of 0.05-2.00 mg/L with correlation coefficient of 0.998 8.The limit for detection for polyoxin was 1.0×10-9 g，and the detection limits of polyoxin in paddy soil and water were 0.05 mg/kg and 0.05 mg/L，respectively.The spiked recoveries of polyoxin in paddy water and soil at spiked concentrations of 0.06,0.60,1.00 mg/kg were in the range of 97%-99% and 95%-97%,with RSDs of 0.71%-2.4% and 1.7%-4.5%，respectively.This method showed the advantages of easy operation，good separation effect and high accuracy，and could meet the requirements for pesticide residue detection.关键词：polyoxin;paddy soil;paddy water;high performance liquid chromatography(HPLC);residue analysis
- 2472
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- 1681
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- 3
发布时间： - 摘要：A micellar electrokinetic capillary chromatographic（MECC） method was established for the separation and determination of three active components，including caffeine，paracetamolum and aspirin，in Paracetamol Caffeine Aspirin Powder.The micellar phase of cholic acid combined with improver of organic base triethanolamine was optimized.The optimal electrophoretic conditions were as follows：buffer：40 mmol/L borate-60 mmol/L cholic acid-12.5% triethanolamine （pH 12.0），separated voltage：15 kV,detection wavelength：254 nm.Under the optimum conditions，the baseline separation of three components in Paracetamol Caffeine Aspirin Powder was achieved within 14 min.The linear calibration curves were in the ranges of 18.75-900.0 mg/L （r=0.999 9） for caffeine，2.60-62.50 mg/L （r=0.992 9） for paracetamolum and 79.17-3 800 mg/L （r=0.994 0） for aspirin.The relative standard deviations of three components were no more than 1.8% for migration time and 6.8% for peak height.The detection limits （S/N=3） were 4.6，0.17,38 mg/L，respectively.The spiked recoveries of three components in Paracetamol Caffeine Aspirin Powder were 100%，100% and 102%，respectively，which could meet the requirement for analyzing reality sample.The improved method is simple，reliable，sensitive and economical，and is suitable for the separation and determination of the multiple ingredients in Paracetamol Caffeine Aspirin Powder.关键词：micellar electrokinetic chromatography;Paracetamol Caffeine Aspirin Powder;caffeine;paracetamolum;aspirin
- 2019
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- 1016
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- 0
发布时间： - 摘要：A simple and sensitive method based on hollow fiber liquid phase microextraction（HF-LPME） was developed to separate， purify and enrich ephedrine and pseudoephedrine in human urine sample.With HF-LPME device，the extraction conditions were optimized.Under the optimal conditions using n-octyl alcohol as organic phase impregnated in the pores of hollow fiber，and acidic microliter solution（pH 2.0）as acceptor phase，the enrichment factors of 180 for ephedrine and 220 for pseudoephedrine were obtained at room temperature with extraction time of 60 min.The calibration curves- were linear in the ranges of 0.01-5 mg/L and 0.005-0.75 mg/L for ephedrine and pseudoephedrine,with their correlation coefficients of 0.998 2 and 0.997 8，respectively.The limits of quantitation（S/N=10） were 0.01 mg/L and 0.005 mg/L，respectively.With the advantages of low organic solvent consumption and high extraction efficiency， the method was suitable for the simultaneous determination of ephedrine and pseudoephedrine in urine sample.关键词：HF-LPME;HPLC;ephedrine;pseudoephedrine;urine sample
- 3291
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- 958
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- 3
发布时间： - 摘要：A rapid resolution liquid chromatography-tandem mass spectrometric(RRLC-MS/MS) method was firstly developed for the determination of Congo red in meat products.Homogenized samples were extracted with acetonitrile-n-hexane mixture(1∶1) and the acetonitrile extraction were transferred for immediate testing after centrifugated by 15 000 r/min for 10 min.The target compound was separated on an Agilent XDB C18 column with acetonitrile-10 mmol/L ammonium formate as mobile phase by gradient elution,and determined by tandem mass spectrometry with multiple reaction monitoring(MRM) mode under negative electrospray ionization mode.The two precursor-product ion pairs,m/z 325.0/416.0 and m/z 651.0/152.0,were used as the quantizative and qualificative ions,respectively.The external standard method was used for quantitative analysis.The results showed a good linearity in range of 0.1-10 mg/L with correlation coefficients higher than 0.999.The average recoveries of three spiked levels including high,medium and low concentrations were between 91% and 102%,with relative standard deviations(RSDs) of 1.2%-4.0%.The limits of detection(LODs) and limits of quantitation(LOQs) were 0.07 mg/kg and 0.18 mg/kg,respectively.The proposed method was accurate and high efficient,and could meet the requirements for the rapid detection of Congo red in meat products.关键词：Congo red;RRLC-MS/MS;meat products
- 2350
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- 1010
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- 6
发布时间： - 摘要：An ion chromatographic(IC) method was developed for the quantitative analysis of ammonia in water borne adhesives.After extracted with 10 mmol/L hydrochloric acid and purified by oscillation centrifugation and filtration,the ammonia was separated by ion chromatography and detected with electrical conductivity detector.The results showed that the ammonia had a good linearity(r2=0.999 8) in the range of 0.05-2.0 mg/L.The detection limit(S/N=3) was 0.007 mg/L and the quantitation limit(S/N=10) was 0.024 mg/L.The average recoveries were between 93% and 102% with relative standard deviations not more than 4.3%.The analysis of real samples verified the reliability of this method.The stability test of ammonia results suggested that the processed samples should be measured in 12 h.关键词：ion chromatography;electrical conductivity detector;water-borne adhesives;ammonia
- 2008
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- 1067
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- 0
发布时间： - 摘要：A method was established for the determination of carbofuran，aldicarb and its metabolite in groundwater by liquid chromatography-electrospray ionization tandem mass spectrometry with direct injection.The optimization conditions of LC and MS were discussed.Methanol and water were chosen as mobile phase.Under the optimal conditions,the calibration curves for carbamate and its metabolite were linear in the range of 0.05-100 μg/L, with correlation coefficients between 0.996 0 and 0.999 3.The limits of detection(S/N≥5) were between 0.01 μg/L and 0.05 μg/L.The recoveries of target compounds at three spiked concentration levels ranged from 90% to 106% with relative standard deviations(RSDs, n=8)of 2.7%-6.5%.This method was accurate and sensitive, and was suitable for the trace determination of carbamate in groundwater.关键词：groundwater;carbofuran;aldicarb;metabolite;LC-MS/MS
- 2218
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- 1088
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- 8
发布时间： - 摘要：Propranolol(PPL) is a nonselective blocking agent of β-adrenoceptor and it has many pharmacology effects.Propranolol is used clinically as racemics with partes aequales of S- and R-propranolol,but the β-adrenoceptor blocking effects of S is 100 times more than that of R-propranolol，and the R form is known to have antioxidant activities.It is important in chiral separation for propranolol enantiomers pharmacokinetics.In this paper,the applications of chromatographic method in resolution of propranolol enantiomers and their pharmacokinetics were reviewed by consulting and summarizing references in order to supply a reference for their further exploitation.关键词：chromatography;propranolol;enantiomer;chiral separation;pharmacokinetics;application
- 2321
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- 983
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- 6
发布时间： - 摘要：The application of mass spectrometric(MS) method and its combination with chromatography,including direct infusion strategies,gas chromatography-MS(GC-MS),supercritical fluid chromatography-MS(SFC-MS) and high performance liquid chromatography-MS(HPLC-MS),in the analysis of triacylglycerols(TAGs) were reviewed.The advantages and disadvantages of these analytical methods and the relevant applications for TAGs analysis were also described.In addition,some databases in common used for lipidomics analysis were introduced,and the development of the analytical methods and their applications in TAGs analysis were prospected.关键词：edible oils;triglycerides;mass spectrometry;chromatography-mass spectrometry;development progress
- 2781
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