Quick Entry
Author Login
Reviewer Login
Editor Login
Biomedical Analysis
About Journal
ISSN:1004-4957
CN:44-1318/TH
Administrator: Guangdong Academy of Sciences
Sponsors: Institute of Analysis,Guangdong Academy of Sciences (Guangzhou Center for Analytical and Testing of China) ; China Association for Instrumental Analysis
Editor-in-Chief: Academician Jiang Guibin
Publication Frequency: Monthly
Tel: 020-87684776
Address: No.100, Xianlie Zhong Road, Guangzhou
- Latest Articles
- Online First
- Archive
2026年第45卷第5期
Special Topic
Organic Light-Emitting Transistor：A Novel Display Technology Integrating Drive and Emission 增强出版 AI导读
摘要：The continuous innovation in display technology is crucial for the development of the information industry. As an emerging type of monolithic integrated driving and light-emitting device，organic light-emitting transistor（OLET） have attracted considerable attention due to their integration of the switching/amplification functions of organic field-effect transistors and the light-emitting characteristics of organic light-emitting diode within a single device architecture. This article reviews the latest advancements in OLET technology in terms of material innovation and device design. In the field of high mobility emissive organic semiconductors，the bottleneck of balancing high mobility with strong luminescence has been successfully overcome through strategies including molecular structure design and aggregation state optimization. In terms of the device performance，leveraging the unique open-plane light-emitting characteristics and gate-voltage modulation mechanism of OLET，highly polarized emission（with a degree of polarization up to 0.97） and ultranarrow spectral emission（with a full width at half maximum as low as 13 nm） have been achieved. These breakthroughs provide a novel technological pathway for the development of next-generation high-performance，multifunctional integrated display technologies，demonstrating the significant potential of OLET in driving the evolution of display technology.关键词：organic light-emitting transistor（OLET）;high mobility emissive organic semiconductor;monolithically integrated driving and light-emitting device;display technology126|83|0更新时间：2026-05-11- 摘要：The clinical diagnosis of ALS lacks early biomarkers，and the complexity of peripheral blood components makes it difficult to directly reflect pathological changes. Blood exosomes，which stably carry protein information from their source cells，provide a window for non-invasive disease monitoring. SUMOylation is a crucial post-translational modification that plays a key regulatory role in disease. However，the characteristics of SUMO-1 modification in the blood exosomes of ALS patients remain unclear. To address this，this study utilized an affinity ligand（CP-1） screened via phage display technology to synthesize a specific enrichment material（M2）. Combined with LC-MS/MS，a proteomic analysis of SUMO-1 modifications was performed on blood exosomes from 4 early-stage and 4 mid-to-late-stage ALS patients. A total of 119 SUMO-1-modified proteins were identified. The overall abundance of these modified proteins was significantly higher in middle-to-late-stage patients compared to early-stage patients，and they were primarily enriched in the chemokine signaling and HIF-1 signaling pathways. These findings suggest that exosomal SUMO-1 modification may be involved in the pathological process of ALS，providing new clues for understanding the disease mechanism.关键词：amyotrophic lateral sclerosis;exosomes;SUMOylation;phage display;LC-MS/MS118|68|0更新时间：2026-05-11
Scientific Papers
摘要：This study employed a high-fat diet（HFD）-induced hyperlipidemia mice model to systematically evaluate the lipid-lowering and hepatoprotective effects of Microctis Folium and to elucidate its regulatory mechanism on the arginine-proline-polyamine metabolic axis using integrated untargeted and targeted metabolomics. Serum untargeted metabolomics was performed using UPLC-QTOF-MS/MS to screen for differential metabolites and conduct pathway enrichment analysis. Subsequently，targeted metabolomics based on UPLC-TQ-MS/MS was employed to quantify key metabolites including L-arginine，proline，creatine，and polyamines（spermidine and spermine）. Microctis Folium significantly reduced TC，TG，and LDL-C levels and decreased ALT and AST while increasing HDL-C across dose groups. Untargeted metabolomics revealed broad metabolic disturbances induced by HFD，with significant enrichment of arginine and proline metabolism；differential metabolites mainly involved amino acids and derivatives，polyamines，creatine-related metabolites，as well as lipids and organic acids. Microctis Folium treatment globally reversed these metabolic abnormalities. Targeted quantification further confirmed that L-arginine，proline，creatine，and polyamines（spermine/spermidine） were decreased in the model group，and Microctis Folium markedly restored their levels toward those of controls. Collectively，Microctis Folium exhibits pronounced lipid-lowering and hepatoprotective activities，which may be mediated by modulation of the arginine-proline-polyamine metabolic axis and associated metabolic remodeling of nitrogen and energy metabolism，thereby promoting restoration of metabolic homeostasis. These findings provide metabolomics-based evidence for the mechanism of action of Microctis Folium and support future screening of its bioactive constituents and translational development.关键词：Microcos Folium;hyperlipidemia;arginine-proline-polyamine metabolism;UPLC-QTOF-MS/MS;UPLC-TQ-MS/MS98|90|0更新时间：2026-05-11- 摘要：In this study，a tertiary amine silane coupling agent bearing bis［3-（trimethoxysilyl）propyl］ groups was first synthesized via the nucleophilic ring-opening reaction of N，N'-dimethyl-1，3-propanediamine with KH560（γ-glycidoxypropyltrimethoxysilane），which was then grafted onto the surface of silica gel. Subsequently，the silane coupling agent-bonded silica microspheres were further reacted with 1，3-propanesultone to afford a bidentate-bonded silica chromatographic stationary phase（denoted as Sil-SAI）. Fourier transform infrared spectroscopy（FT-IR） and elemental analysis（EA） confirmed that the Sil-SAI stationary phase was successfully modified with sulfobetaine zwitterionic and tertiary amine bifunctional groups.Furthermore，the separation mechanism of the Sil-SAI column，the effects of buffer salt concentration and pH value of the mobile phase on chromatographic retention behavior，as well as the hydrolytic stability of the stationary phase were systematically investigated. The results indicated that：Sil-SAI exhibits a typical hydrophilic interaction liquid chromatography（HILIC） separation mechanism. Owing to the multiple interactions（including hydrophilic interaction，electrostatic interaction，hydrogen bonding，and dipole-dipole interactions） between probe molecules and the Sil-SAI stationary phase，this stationary phase presents a mixed separation mechanism involving both partition and adsorption processes；With variations in the concentration and pH of the buffer salt in the mobile phase，the neutral，acidic，and basic probe molecules display distinct chromatographic retention behaviors；Benefiting from its bidentate bonding structure，the Sil-SAI stationary phase possesses superior hydrolytic stability.The application of Sil-SAI stationary phase for the separation of six sugars and seven sugar alcohols demonstrated excellent separation efficiency and satisfactory separation reproducibility for all analytes.关键词：bidentate-bonded;sulfobetaine functional group;HILIC chromatographic column;sugar compounds;sugar alcohols98|83|0更新时间：2026-05-11
- 摘要：Gas chromatography-ion mobility spectrometry（GC-IMS） was employed to analyze the volatile components of Cyperi Rhizoma from different origins. Partial least squares-discriminant analysis（PLS-DA） was applied to screen differential characteristic components. Based on these characteristic components，9 machine learning algorithms such as SVM-L were constructed to develop rapid discrimination models for Cyperi Rhizoma from different origins. Fifty-nine volatile compounds were identified in Cyperi Rhizoma decoction pieces from five provinces，including alcohols，esters，aldehydes，ketones，and unsaturated hydrocarbons. Ten characteristic components were screened by PLS-DA analysis，such as 1，4-dimethylbenzene，3-methyl-1-pentanol，and ethyl acetoacetate. Furthermore，nine machine learning models all demonstrated excellent predictive performance（Accuracy=1），indicating good potential for practical application. This study provides a simple and rapid method for discrimination and identification of Cyperi Rhizoma from different geographical origins，while also offering a reference for establishing a quality evaluation system for Cyperi Rhizoma.关键词：gas chromatography-ion mobility spectrometry（GC-IMS）;Cyperi Rhizoma;volatile components;geographical origins;machine learning74|77|0更新时间：2026-05-11
- 摘要：The identification of HN-DNA adducts formed in animals after exposure to nitrogen mustards（NMs，codenamed HN） enables the traceability and confirmatory analysis of HN exposure. Six-week-old Sprague-Dawley（SD） rats，with a mean weight of approximately 200 g，were given intraperitoneal injections of HN1，HN2，and HN3，respectively，to establish an exposure animal model. The nitrogen mustard exposure groups（0.3 LD50，0.5 LD50，or LD50 exposure dose） as well as a blank solvent control group were set up. A high-performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） method employing multiple reaction monitoring（MRM） mode was established to quantitatively analyze the types and concentrations of HN-DNA adducts in rat urine samples. The results demonstrated a good linearity for the 12 HN-DNA adduct standards within the concentration range of 0.02-500 ng/mL，with limits of detection（LODs） of 0.01-0.02 ng/mL and limits of quantification（LOQs） of 0.02-0.05 ng/mL. The relative standard deviations（RSDs） of intra-assay and inter-assay precision were less than 15%. Urine analysis of HN-exposed SD rats at 12 hours post-exposure revealed the presence of HN-AN3，HN-GN7，HN-GO6，and HN-Bis-GN7 adducts，with concentrations decreasing in the order of HN-GN7>HN-Bis-GN7>HN-AN3>HN-GO6. The concentrations of the four DNA adducts demonstrated a dose-dependent positive correlation and a gradual decrease over time. The application of HPLC-MS/MS technique to detect these urinary DNA adducts allows for the non-invasive early detection，accurate traceability，and damage assessment of HN exposure. These findings provide an experimental basis for further study of HN-induced DNA damage repair processes and mechanisms.关键词：nitrogen mustard;DNA adducts;biomarker;traceability analysis;high-performance liquid chromatography-tandem mass spectrometry105|145|0更新时间：2026-05-11
- 摘要：A detection method based on dispersive solid phase extraction coupled with ultra-performance liquid chromatography-tandem mass spectrometry（d-SPE/UPLC-MS/MS） was established for the simultaneous determination of 19 chemical components in roasted coffee. This method compared the effects of solvent type，feed-to-solvent ratio，solvent pH value，ascorbic acid concentration，ultrasonication time，and the type and amount of adsorbent used as the packing material for sample purification. The optimal experimental conditions selected were a solid-liquid ratio of 1∶10，with 70% ethanol aqueous solution at pH 2 as the extraction solvent，the ascorbic acid concentration was 5 mg/mL，ultrasound time of 60 minutes，and purification packing consisting of 60 mg octadecylsilane（C18），30 mg diatomaceous earth（DE），and 20 mg primary secondary amine（PSA）. Using a 0.01% formic acid aqueous solution and a 0.01% formic acid methanol as the mobile phase，separation was achieved within 6 minutes using a Kinetex PFP column（100 mm×3 mm，2.6 μm）. The validation results demonstrated an excellent linear relationship for all 19 compounds across the concentration range of 0.2-5 000 μg/L（r²>0.995）. The verification results show that，with the exception of malic acid（LOD is 100 μg/L；LOQ is 200 μg/L），the limits of detection（LODs） and limits of quantification（LOQs） for the other 18 compounds range from 0.1 to 20 μg/L and 0.2 to 50 μg/L，respectively. The recoveries for spiked samples at three concentration levels ranged from 73.2% to 111%，with relative standard deviations ranging from 1.4% to 11%. This method was applied to the analysis of 21 batches coffee samples from Yunnan with different processing combinations（variety×processing method×roasting degree），and combined with principal component analysis（PCA） for statistical analysis. The results indicated that among the measured chemical components，Yellow Bourbon has the highest total sum，in addition，the content of the majority of phenolic acids contained in coffee beans tends to decrease gradually as the degree of roasting increases. For the part of flavonoids，which mainly include catechin and epicatechin，tends to increase steadily with the degree of roasting. This research not only provides a specific technical method for detecting chemical components in Yunnan coffee but also offers reliable theoretical support for the processing procedures and production practices of high-quality coffee.关键词：coffee;chemical components;dispersed solid phase extraction;UPLC-MS/MS;principal component analysis108|129|0更新时间：2026-05-11
查看更多
Rankings 
更多
- 0 1 Research Progress of Design，Synthesis and Application of Fluorescent Nanoprobe 3224
- 0 2 Recent Advances in the Application of Machine Learning in Environmental Analysis and Detection 3100
- 0 3 Recent Progress in Nuclear Radiation Detection Technology and Device 2824
- 0 4 Advances in Tissue Penetration by Optical Imaging Techniques 2560
- 0 5 Research Progress and Prospects of Sonodynamic Therapy 2367
查看更多
- Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
- Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
- Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：874686 Visits Today：15
0