Rapid Determination of Paraquat in Whole Blood and Urine by Matrix Assisted Laser Desorption Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

陈超; 罗辉泰; 张秋炎; 杨运云; 向章敏; 刘舒芹

doi:doi：10.3969/j.issn.1004-4957.2020.09.010

您当前的位置：

首页 >

文章列表页 >

Rapid Determination of Paraquat in Whole Blood and Urine by Matrix Assisted Laser Desorption Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

更新时间：2023-04-18

- Rapid Determination of Paraquat in Whole Blood and Urine by Matrix Assisted Laser Desorption Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
- Vol. 39, Issue 9, Pages: 1126-1130(2020)
- 作者机构：
  
  广东省科学院广东省测试分析研究所(中国广州分析测试中心)广东省原位电离质谱分析工程技术研究中心
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2020.09.010
  CLC：
- Published：2020
- 稿件说明：
移动端阅览
陈超, 罗辉泰, 张秋炎, 杨运云, 向章敏, 刘舒芹. Rapid Determination of Paraquat in Whole Blood and Urine by Matrix Assisted Laser Desorption Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry[J]. 2020, 39(9): 1126-1130.
DOI：

陈超, 罗辉泰, 张秋炎, 杨运云, 向章敏, 刘舒芹. Rapid Determination of Paraquat in Whole Blood and Urine by Matrix Assisted Laser Desorption Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry[J]. 2020, 39(9): 1126-1130. DOI： doi：10.3969/j.issn.1004-4957.2020.09.010.

摘要

该文建立了一种利用基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱(MALDI-FTICR-MS)快速测定全血及尿液中百草枯的分析方法。采用含1%甲酸的乙腈溶液从生物样品中提取百草枯，并与2

5-二羟基苯甲酸溶液混合后直接进样分析。结果表明，全血、尿液和水中的百草枯在10~5 000 μg/L质量浓度范围内线性良好，相关系数(r)为0.995 5~0.999 2；3种基质下的方法检出限(LOD

S/N=3)为0.6~3.0 μg/L，定量下限(LOQ，S/N=10)为2.0~10 μg/L；百草枯在全血和尿液中的平均回收率为85.2%~110%，相对标准偏差(RSD)为0.40%~7.3%。该方法具有所需样品和溶剂用量少，操作简单，分析速度快，灵敏度高，且稳定可靠等特点，可满足临床及司法鉴定相关的中毒快检需求。

Abstract

A matrix assisted laser desorption ionization-Fourier transform ion cyclotron resonance mass spectrometric(MALDI-FTICR-MS) method was developed for rapid determination of paraquat in whole blood and urine.The sample was extracted by liquid-liquid extraction method

with acetonitrile solution containing 1% formic acid as extraction solvent.Prior to analysis

the extracted solution was mixed with 2

5-dihydroxybenzoic acid.Results showed that there were good linear relationships for paraquat in whole blood and urine samples in the mass concentration range of 10-5 000 μg/L

with correlation coefficients(r) of 0.995 5-0.999 2.The limits of detections(LODs) and limits of quantitations(LOQs) of the method were in the ranges of 0.6-3.0 μg/L and 2.0-10 μg/L

respectively.The average recoveries at spiked levels ranged from 85.2% to 110%

with relative standard deviations(RSDs) of 0.40%-7.3%.The method showed the advantages of low sample and solvent consumption

simple operation

rapid analysis and high sensitivity

and could meet the requirements for rapid detection of clinical poisoning and forensic.

关键词

Keywords

references

Views

325

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Rapid Determination of Paraquat and Diquat in Vegetables by Matrix Assisted Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Identification of the 2-FXE and Its Metabolites in Human Urine by UPLC-QTOF MS

Preparation of Nitrogen and Chlorine Co-doped Carbon Quantum Dots and Their Application in Detection of 6 Kinds of Tetracycline Antibiotics

Simultaneous Determination of p-Phenylenediamines and Their Quinone Derivatives in Human Urine by Solid-phase Extraction Combined with LC-MS/MS

Advances and Perspectives in Imaging，Identification，and Quantification Technologies for Micro/nanoplastics in Plants

Related Author

陈超

潘佳钏

刘舒芹

郭鹏然

XU Fang-min

ZHANG Qiang

WANG Xue-hu

LIU Ling-yun

Related Institution

广东省科学院测试分析研究所(中国广州分析测试中心)广东省化学危害应急检测技术重点实验室

广东省科学院测试分析研究所(中国广州分析测试中心)广东省原位电离质谱分析工程技术研究中心

Institute of Forensic Science，Public Security Bureau of Jiangyin，Jiangyin

Institute of Forensic Science，Public Security Department of Inner Mongolia

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：939937 Visits Today：1737

⁰