A high performance liquid chromatography with magnetic zeolitic imidazolate framework (ZIF-8@Fe3O4) solid phase extraction was developed for the determination of three benzoylurea insecticides)(BUs)

ie.penfluron

clofentezine and chlorfluazuron in fruit juice samples.The prepared ZIF-8@Fe3O4 sorbent was characterized by X-ray diffraction

Fourier transform infrared spectrometry

scanning electron microscopy and vibrating sample magnetometry.The extraction parameters were optimized

including pH value of solution

amount of sorbent

extraction time

eluting solvent type and volume(single elution volume×elution times).Under the optimized conditions

there were good linear relationships in the range of 2.0-200 ng/mL for penfluron and clofentezine and 3.5-350 ng/mL for chlorfluazuron

with correlation coefficients(r) of 0.999.The limits of detection(S/N=3) for three analytes were in the range of 0.6-1.0 ng/mL

and the limits of quantitation(S/N=10) were 2.0-35 ng/mL.The recoveries for all targets at three spiked levels in fruit juice samples ranged from 82.7% to 98.6%

with intra-day and inter-day relative standard deviations(RSD) of 1.2%-6.1% and 1.3%-9.0%

respectively.The enhancement factors ranged from 43.4 to 48.1 for all the analytes when 10 mL juice sample was used as loading solution.The reusability of the fabricated ZIF-8@Fe3O4 adsorbent was investigated

and the RSD for recoveries of benzoylurea insecticides for 10 consecutive adsorption-desorption cycles in sample solutions were not more than 8.8%.The proposed method is sensitive and effective

and could be applied in the determination of benzoylurea insecticides in fruit juice samples.