Preparation and Uncertainty Valuation of Naringenin Certified Reference Material

刘金涛; 李玲; 董家吏; 焦必宁; 苏学素

doi:doi：10.3969/j.issn.1004-4957.2020.02.004

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Preparation and Uncertainty Valuation of Naringenin Certified Reference Material

更新时间：2023-05-25

- Preparation and Uncertainty Valuation of Naringenin Certified Reference Material
- Vol. 39, Issue 2, Pages: 190-197(2020)
- 作者机构：
  
  1. 西南大学化学化工学院
  2. 中国农业科学院/西南大学柑橘研究所
  3. 农业农村部柑橘产业质量安全风险评估实验室
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2020.02.004
  CLC：
- Published：2020
- 稿件说明：
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刘金涛, 李玲, 董家吏, 焦必宁, 苏学素. Preparation and Uncertainty Valuation of Naringenin Certified Reference Material[J]. 2020, 39(2): 190-197.
DOI：

刘金涛, 李玲, 董家吏, 焦必宁, 苏学素. Preparation and Uncertainty Valuation of Naringenin Certified Reference Material[J]. 2020, 39(2): 190-197. DOI： doi：10.3969/j.issn.1004-4957.2020.02.004.

摘要

建立了柚皮素标准物质的研制和定值方法。通过红外光谱和核磁共振氢谱对样品进行定性分析，经过柱层析纯化、干燥、混匀后，分装得到120瓶样品。采用质量平衡法和差示扫描量热法进行定值分析(质量平衡法包括液相色谱面积归一化法、水分、无机杂质和残留溶剂的测定)。运用液相色谱法考察了样品的均匀性和稳定性，并对定值结果进行了不确定度评定。结果显示，研制的柚皮素标准物质具有良好的均匀性和稳定性，定值结果为99.2%，扩展不确定度为0.2%，有效期6个月。

Abstract

A method for preparation and determination of naringenin certified reference material was established.Qualitative analysis of purchased samples was performed using infrared spectroscopy and nuclear magnetic resonance.The samples were purified by column chromatography and dried at 105 ℃ for 6 h

after mixing and dispensing

120 bottles of reference material candidates were obtained.Purity determination was carried out by differential scanning calorimetry and mass balance method.The mass balance method based on area normalization method of liquid chromatography

included detections on contents of moisture

inorganic impurities and residual solvents.Homogeneity and stability studies were validated by liquid chromatography

and uncertainty of the determination results was also analyzed.Results showed that the developed naringenin certified reference material had good homogeneity and stability

with a purity of 99.2%

an expanded uncertainty of 0.2%(k=2) and a validity period of 6 months.

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