Determination of Lead in Serum by ICP-MS Based on Magnetic Particle Enrichment

杨茹; 赵珍阳; 龚子珊; 汪曣; 傅霜; 韩文念; 张勇; 王世功; 孙传强

doi:doi：10.3969/j.issn.1004-4957.2019.11.013

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Determination of Lead in Serum by ICP-MS Based on Magnetic Particle Enrichment

- Determination of Lead in Serum by ICP-MS Based on Magnetic Particle Enrichment
- Vol. 38, Issue 11, Pages: 1364-1368(2019)
- 作者机构：
  
  1. 天津大学精密仪器与光电子工程学院
  2. 山东东仪光电仪器有限公司
  3. 天津国科医工科技发展有限公司
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.11.013
  CLC：
- Published：2019
- 稿件说明：
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杨茹, 赵珍阳, 龚子珊, 汪曣, 傅霜, 韩文念, 张勇, 王世功, 孙传强. Determination of Lead in Serum by ICP-MS Based on Magnetic Particle Enrichment[J]. 2019, 38(11): 1364-1368.
DOI：

杨茹, 赵珍阳, 龚子珊, 汪曣, 傅霜, 韩文念, 张勇, 王世功, 孙传强. Determination of Lead in Serum by ICP-MS Based on Magnetic Particle Enrichment[J]. 2019, 38(11): 1364-1368. DOI： doi：10.3969/j.issn.1004-4957.2019.11.013.

摘要

以FeCl3·6H2O为原料一步合成了粒径为400 nm的Fe3O4磁性微粒，并用于人血清中Pb2+的检测。用Zeta电位仪和单颗粒电感耦合等离子体质谱(SP-ICP-MS)对所合成的Fe3O4磁性微粒进行表征。通过微波消解法对血清样品进行预处理，经Fe3O4磁性微粒分离富集后，采用ICP-MS法检测。优化了Fe3O4磁性微粒分离富集Pb2+的实验条件，并在pH 5.0，吸附剂用量400 μL，吸附30 min的条件下，成功实现了血清中Pb2+的定量检测，富集因子为10。Pb2+的检出限为7 ng/L，定量下限为23.1 ng/L。

Abstract

Magnetic particles with a particle size of 400 nm were synthesized in one step by hydrothermal method for the detection of Pb2+ in human serum.They were characterized by Zeta potentiometry and single particle inductively coupled plasma mass spectrometry(SP-ICP-MS).The serum samples were pretreated by microwave digestion method

then separated and enriched with Fe3O4 magnetic particles

and finally detected by ICP-MS.Experimental conditions for the separation and enrichment of Pb2+ using Fe3O4 magnetic particles were optimized.The quantitative detection of Pb2+ in serum was successfully achieved at pH 50

using a 400 μL of adsorbent adsorbing for 30 min

and the enrichment factor was 10.The limit of detection(LOD) and the limit of quantitation(LOQ) were 7 ng/L and 23.1 ng/L

respectively.

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