Advances in Detection Methods for Telomerase

孙丽芳; 杨海堂; 卫伟

doi:doi：10.3969/j.issn.1004-4957.2019.10.020

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Advances in Detection Methods for Telomerase

- Advances in Detection Methods for Telomerase
- Vol. 38, Issue 10, Pages: 1280-1284(2019)
- 作者机构：
  
  1. 国家知识产权局复审和无效审理部
  2. 东南大学化学化工学院
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.10.020
  CLC：
- Published：2019
- 稿件说明：
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孙丽芳, 杨海堂, 卫伟. Advances in Detection Methods for Telomerase[J]. 2019, 38(10): 1280-1284.
DOI：

孙丽芳, 杨海堂, 卫伟. Advances in Detection Methods for Telomerase[J]. 2019, 38(10): 1280-1284. DOI： doi：10.3969/j.issn.1004-4957.2019.10.020.

摘要

端粒酶是一种核蛋白逆转录酶，能以自身的RNA为模板添加重复序列(TTAGGG)n至染色体末端，稳定端粒长度。端粒酶在85%~90%的癌细胞中处于激活状态，已经引起了人们的广泛关注，成为肿瘤诊断和临床治疗的重要突破口。因此，准确、高效地测定端粒酶活性具有重要意义。近年来，许多灵敏、准确的体外或原位检测技术在端粒酶活性检测方面得到了发展。该文综述了近年来端粒酶活性检测的最新进展，并对其发展趋势进行了展望。

Abstract

Telomerase is a nuclear protein reverse transcriptase that adds the repeat sequence(TTAGGG)n to the end of chromosome with its own RNA template to stabilize the telomere length.Telomerase is activated in 85% to 90% of cancer cells

which has attracted a widespread concern and become an important breakthrough in tumor diagnosis and clinical treatment.Therefore

accurate and efficient determination of telomerase activity is of great significance.In recent years

many sensitive and accurate in vitro or in situ detection techniques have been developed for the detection of telomerase activity.In this paper

recent advances in the detection of telomerase activity have been reviewed

and the development trend for telomerase detection has been prospected.

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