Capillary electrophoresis(CE)

a highly mature and versatile technique

has been continually evolving in the last three decades.Capillary electrophoresis has important applications in the field of biological analysis such as protein separation due to its advantages of short separation time

high separation efficiency and low sample consumption

etc.However

many drawbacks have been caused by dissociation of silicon hydroxyl on inner wall of capillary in CE separation process.To overcome these drawbacks associated with CE

modification of capillary inner surfaces by antifouling polymer coatings are chosen.The antifouling polymer modified capillary method could not only regulate the electroosmotic flow

but also benefit the proteins separation.This method could also effectively improve the separation efficiency and separation stability for proteins in CE process.The paper presents a review on the latest research progress of capillary coatings

like dynamic and static polymer coating for protein separation.It also summarizes the research progress of polymer coating capillary based on dopamine/polydopamine anchored.And finally

the prospects of the future development trend of polymer coatings of capillary are discussed.