Determination of Ribavirin by Electrochemical Luminescence with TiO2-CdTe

吴可心; 田利; 胡玥; 王月; 陆娟

doi:doi：10.3969/j.issn.1004-4957.2019.08.017

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Determination of Ribavirin by Electrochemical Luminescence with TiO2-CdTe

- Determination of Ribavirin by Electrochemical Luminescence with TiO2-CdTe
- Vol. 38, Issue 8, Pages: 1000-1004(2019)
- 作者机构：
  
  长春师范大学化学学院
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.08.017
  CLC：
- Published：2019
- 稿件说明：
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吴可心, 田利, 胡玥, 王月, 陆娟. Determination of Ribavirin by Electrochemical Luminescence with TiO2-CdTe[J]. 2019, 38(8): 1000-1004.
DOI：

吴可心, 田利, 胡玥, 王月, 陆娟. Determination of Ribavirin by Electrochemical Luminescence with TiO2-CdTe[J]. 2019, 38(8): 1000-1004. DOI： doi：10.3969/j.issn.1004-4957.2019.08.017.

摘要

将碲化镉量子点(CdTe)与二氧化钛(TiO2)的复合物修饰至玻碳电极表面，构建了TiO2-CdTe/GCE电化学发光传感平台，并对其电化学发光性质进行研究。在含有联吡啶钌和三正丙胺的碱性缓冲溶液中，TiO2-CdTe/GCE产生很强的电化学发光信号，随着利巴韦林的加入，该体系的电化学发光信号发生明显猝灭，据此建立了一种新的利巴韦林含量的检测方法。在优化实验条件下，利巴韦林在3.9×10-4~3.9 μmol· L-1范围内，其浓度的对数与相对电化学发光强度呈现良好的线性关系，检出限为1.3×10-10 mol·L-1。对注射液中利巴韦林含量进行测定，回收率为96.6 %~101%，结果满意。

Abstract

A novel electrochemical luminescence method was established for the detection of ribavirin based on a TiO2-CdTe glassy carbon electrode(GCE).The TiO2-CdTe/GCE electrochemical luminescence(ECL) sensor platform was constructed by immobilizing a CdTe-TiO2 complex onto the surface of glassy carbon electrode

which ECL properties were studied.The TiO2-CdTe/GCE exhibited an efficient and stable ECL signal in alkaline buffer solution containing Ru(bpy)2+3 and trinpropylamine(TprA).The ECL signal was obviously quenched when a certain amount of ribavirin was added.Thus

a new detection method for ribavirin was established.Under the optimized conditions

the ECL signal intensity depends linearly on the logarithm of ribavirin concentration in the range of 3.9×10-4-3.9 μmol·L-1

and the detection limit(S/N=3) was 1.3×10-10 mol·L-1.The method was successfully applied in the detection of ribavirin in injection with recoveries of 96.6%-101%.

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