A high performance liquid chromatographic(HPLC)method was developed for the determination of 4 banned phenols
i.e.phloroglucinol
4-nitroguaiacol
phenolphthalein and dinoseb in water-based
emulsions
creams
powder and waxy based cosmetics.After a clean up process of vortex extraction and nitrogen blowing concentration
the analytes were redissolved with optimized solvent.The qualitative analysis was based on retention time and ultraviolet absorbance
while quantitative analysis was performed by the external standard method.There existed good linear relationships for four analytes in the certain concentration range,with correlation coefficients(r2) more than 0.99.The limits of detection(LOD)and limits of quantitation(LOQ)for 4 banned phenols were in the ranges of 1.5-6.0 mg/kg and 5.0-20.0 mg/kg
respectively.The spiked recoveries for four analytes were in the range of 81.3%-100% with relative standard deviations(RSD)of 1.0%-8.2%.The developed method was applicable for the determination of 4 banned phenols in cosmetic with simple pretreatment and easy operation.
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Related Author
MAO Xi-qin
ZHANG Rong
WANG Dong
JIANG Bo-hai
YU Ben-tao
XUE Heng-yue
LI Yue-chen
GONG Shan-shan
Related Institution
Dalian Institute For Drug Control
School of Chemical Engineering,Dalian University of Technology