Determination of 11 Common Psychotropic Drugs in Human Hair by High Performance Liquid Chromatography-Tandem Mass Spectrometry with Supercritical Fluid Carbon Dioxide Extraction

徐代化; 欧军; 陈深树; 徐期林; 陈垚翰; 程良红

doi:doi：10.3969/j.issn.1004-4957.2019.08.013

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Determination of 11 Common Psychotropic Drugs in Human Hair by High Performance Liquid Chromatography-Tandem Mass Spectrometry with Supercritical Fluid Carbon Dioxide Extraction

- Determination of 11 Common Psychotropic Drugs in Human Hair by High Performance Liquid Chromatography-Tandem Mass Spectrometry with Supercritical Fluid Carbon Dioxide Extraction
- Vol. 38, Issue 8, Pages: 979-984(2019)
- 作者机构：
  
  1. 广东南天司法鉴定所
  2. 深圳黑尔格科技有限公司
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.08.013
  CLC：
- Published：2019
- 稿件说明：
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徐代化, 欧军, 陈深树, 徐期林, 陈垚翰, 程良红. Determination of 11 Common Psychotropic Drugs in Human Hair by High Performance Liquid Chromatography-Tandem Mass Spectrometry with Supercritical Fluid Carbon Dioxide Extraction[J]. 2019, 38(8): 979-984.
DOI：

徐代化, 欧军, 陈深树, 徐期林, 陈垚翰, 程良红. Determination of 11 Common Psychotropic Drugs in Human Hair by High Performance Liquid Chromatography-Tandem Mass Spectrometry with Supercritical Fluid Carbon Dioxide Extraction[J]. 2019, 38(8): 979-984. DOI： doi：10.3969/j.issn.1004-4957.2019.08.013.

摘要

建立了一种超临界二氧化碳萃取(SFE)结合高效液相色谱-串联质谱(HPLC-MS/MS)测定毛发中11种常见精神药物的方法，并应用于实际毛发样品的检测。剪碎的毛发样品在优化的SFE条件下萃取，提取液经氮吹浓缩，以甲醇定容至100 μL后，进行HPLC-MS/MS测定。结果表明，11种常见精神药物在2~200 ng/mL范围内线性良好，相关系数(r2)大于0.999

方法检出限为0.01~0.05 ng/mg，定量下限为 0.03~0.10 ng/mg；在0.05、0.20、0.40 ng/mg加标水平下，方法的回收率为81.6%~94.8%，相对标准偏差(RSD)为0.50%~3.4%。该方法快速、灵敏、准确，可用于毛发中11种常见精神药物的同时检测。

Abstract

A high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) with supercritical fluid carbon dioxide extraction(SFE) was established for the determination of 11 common psychotropic drugs in human hair.The sheared hair samples were extracted by SFE under optimized conditions.The concentrated extract was reconstituted to 100 μL with methanol

then analyzed by HPLC-MS/MS.Results showed that there existed good linear relationships for 11 common psychotropic drugs in the range of 2-200 ng/mL

with correlation coefficients(r2) greater than 0.999.The detection limits and the quantitation limits were in the ranges of 0.01-0.05 ng/mg and 0.03-0.10 ng/mg

respectively.Recoveries at the spiked levels of 0.05

0.20 and 0.40 ng/mg ranged from 816% to 94.8% with relative standard deviations(RSD) of 0.50%-3.4%.The method is rapid

sensitive and accurate

and could be used in simultaneous detection of 11 common psychotropic drugs in human hair.

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