Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation

赵双丽; 罗菲菲; 祝璐琪; 王清江; 何品刚

doi:doi：10.3969/j.issn.1004-4957.2019.07.017

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Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation

- Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation
- Vol. 38, Issue 7, Pages: 865-869(2019)
- 作者机构：
  
  华东师范大学化学与分子工程学院
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.07.017
  CLC：
- Published：2019
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赵双丽, 罗菲菲, 祝璐琪, 王清江, 何品刚. Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation[J]. 2019, 38(7): 865-869.
DOI：

赵双丽, 罗菲菲, 祝璐琪, 王清江, 何品刚. Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation[J]. 2019, 38(7): 865-869. DOI： doi：10.3969/j.issn.1004-4957.2019.07.017.

摘要

该文在水相溶剂中绿色合成了γ 氨基丁酸键合硅胶(Sil-GABA)色谱固定相，采用红外光谱、元素分析等对其进行了表征，并将制备的Sil-GABA材料作为毛细管色谱柱的填料研究了其色谱分离模式和分析性能。结果显示，在以乙酸铵水溶液为流动相的条件下，该填料可有效分离硝基氯苯3种位置异构体和7种磺胺，表明Sil-GABA固定相具有富水作用色谱的特性；在高浓度有机流动相条件下可有效分离4种苯甲酸类化合物，表明Sil-GABA具有亲水作用色谱的特性；此外，该Sil-GABA固定相在反相模式下对硝基苯胺异构体也有一定的分离能力。在优化条件下，7种磺胺保留时间的相对标准偏差小于32%，表明制得的色谱柱具有良好的重复性。该Sil-GABA固定相具有多种保留机理，在毛细管液相色谱分离领域具有潜在的应用价值。

Abstract

A γ aminobutyric acid bonded silica(Sil-GABA) stationary phase was prepared in a green medium with only water as solvent

which was characterized by Fourier transform infrared spectroscopy and elemental analysis.The separation mode and analytical performance of the Sil-GABA stationary phase were evaluated through a series of experiments when it was used as packing material for capillary column.Results showed that three nitrochlorobenzene positional isomers and seven sulfonamides were separated effectively on the Sil-GABA stationary phase with ammonium acetate as mobile phase in an aqueous liquid chromatography mode.Four benzoic acid compounds were separated with high concentrations of organic solvents as mobile phases in a hydrophilic chromatography mode.Additionally

three nitroaniline positional isomers were also separated in a reversed phase chromatography mode.Under the optimal conditions

the relative standard deviations(RSD) of the retention times for the sulfonamides were within 32%

indicating that the Sil-GABA column has a good reproducibility.The prepared Sil-GABA stationary phase could provide potential applications in capillary liquid chromatography with multiple retention mechanisms.

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