Determination of Chromium(Ⅵ) and Chromium(Ⅲ) in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

吴思霖; 王欣美; 潘晨; 于建; 张凯; 王柯; 郑荣

doi:doi：10.3969/j.issn.1004-4957.2019.06.015

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Determination of Chromium(Ⅵ) and Chromium(Ⅲ) in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

- Determination of Chromium(Ⅵ) and Chromium(Ⅲ) in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry
- Vol. 38, Issue 6, Pages: 724-727(2019)
- 作者机构：
  
  上海市食品药品检验所
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.06.015
  CLC：
- Published：2019
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吴思霖, 王欣美, 潘晨, 于建, 张凯, 王柯, 郑荣. Determination of Chromium(Ⅵ) and Chromium(Ⅲ) in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry[J]. 2019, 38(6): 724-727.
DOI：

吴思霖, 王欣美, 潘晨, 于建, 张凯, 王柯, 郑荣. Determination of Chromium(Ⅵ) and Chromium(Ⅲ) in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry[J]. 2019, 38(6): 724-727. DOI： doi：10.3969/j.issn.1004-4957.2019.06.015.

摘要

建立了一种有效分离检测化妆品中Cr(Ⅵ)和Cr(Ⅲ)的高效液相色谱-电感耦合等离子体质谱(HPLC-ICP-MS)分析方法。以10 mmol/L(pH 7.0)EDTA为提取溶剂，0.075 mol/L 硝酸(pH 7.0，氨水调节)为流动相，采用Agilent Bio-WAX柱(4.6 mm×50 mm

5 μm)对样品提取液进行分离，电感耦合等离子体质谱进行测定。在优化实验条件下，Cr(Ⅵ)和Cr(Ⅲ)在0~100 μg/L 范围内线性关系良好，相关系数(r2)均为0.999 9。Cr(Ⅵ)和Cr(Ⅲ)的检出限分别为6、2 μg/kg，定量下限分别为18、6 μg/kg，加标回收率为85.1%~113%，相对标准偏差为0.4%~4.6%。实际样品的测定结果显示，在膏霜乳液类及粉类样品中检出Cr(Ⅵ)和Cr(Ⅲ)。该方法重现性好、灵敏度高，且Cr(Ⅵ)在中性条件下较稳定，不易转化为Cr(Ⅲ)，适用于不同基质类型化妆品中Cr(Ⅵ)和Cr(Ⅲ)的同时检测。

Abstract

A method was developed for the simultaneous determination of chromium(Ⅵ) and chromium(Ⅲ) by high performance liquid chromatography-inductively coupled plasma mass spectrometry(HPLC-ICP-MS).The sample was extracted with 10 mmol/L EDTA solution(pH 7.0).The chromatographic separation was performed on an Agilent Bio-WAX column(4.6 mm×50 mm

5 μm) utilizing 0.075 mol/L nitric acid(pH 7.0) as mobile phase.Identification and quantitation were achieved by ICP-MS.Under the optimal conditions

the linear ranges for Cr(Ⅵ) and Cr(Ⅲ) were observed from 0 μg/L to 100 μg/L with correlation coefficients(r2) of 0.999 9.The limits of detection for Cr(Ⅵ) and Cr(Ⅲ) were 6 μg/kg and 2 μg/kg

and the limits of quantitation were 18 μg/kg and 6 μg/kg

respectively.Average recoveries for Cr(Ⅵ) and Cr(Ⅲ) at three spiked levels ranged from 85.1% to 113% with relative standard deviations of 0.4%-4.6%.Through the analysis of actual samples

Cr(Ⅵ) and Cr(Ⅲ) were detected out in cream lotion and powder cosmetics.With good reproducibility and high sensitivity

this method is suitable for the simultaneous determination of Cr(Ⅵ) and Cr(Ⅲ) in different types of cosmetics as Cr(Ⅵ) is stable under neutral conditions.

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