Determination of Minocycline Hydrochloride Using a Novel Fluorescence Turn-on Method Based on Rapeseed Carbon Quantum Dots

武文波; 张越诚; 马红燕; 田锐; 刘晓莉

doi:doi：10.3969/j.issn.1004-4957.2019.04.016

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Determination of Minocycline Hydrochloride Using a Novel Fluorescence Turn-on Method Based on Rapeseed Carbon Quantum Dots

- Determination of Minocycline Hydrochloride Using a Novel Fluorescence Turn-on Method Based on Rapeseed Carbon Quantum Dots
- Vol. 38, Issue 4, Pages: 471-476(2019)
- 作者机构：
  
  1. 延安大学化学与化工学院
  2. 延安市分析技术与检测重点实验室
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.04.016
  CLC：
- Published：2019
- 稿件说明：
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武文波, 张越诚, 马红燕, 田锐, 刘晓莉. Determination of Minocycline Hydrochloride Using a Novel Fluorescence Turn-on Method Based on Rapeseed Carbon Quantum Dots[J]. 2019, 38(4): 471-476.
DOI：

武文波, 张越诚, 马红燕, 田锐, 刘晓莉. Determination of Minocycline Hydrochloride Using a Novel Fluorescence Turn-on Method Based on Rapeseed Carbon Quantum Dots[J]. 2019, 38(4): 471-476. DOI： doi：10.3969/j.issn.1004-4957.2019.04.016.

摘要

以油菜籽和水为原料，一步合成了强荧光碳量子点（CQDs）。基于KMnO4能使该CQDs的荧光显著猝灭；而当有盐酸米诺环素（MINO）存在时，CQDs-KMnO4体系的荧光恢复，使荧光信号重新“打开”的原理，提出了以油菜籽CQDs荧光信号的“关开”为荧光探针测定盐酸米诺环素的新方法。方法的线性范围为5.0×10-7~1.0×10-5 mol/L，相关系数r=0.999 5，方法检出限为4.9×10-7 mol/L。方法用于样品中盐酸米诺环素的测定，回收率为99.6%~100%。通过紫外-可见吸收光谱的变化和荧光寿命的测定，确定CQDs与KMnO4间的猝灭类型为动态猝灭。同时对体系的“关-开”机理进行了初步探讨。

Abstract

In this paper

a new fluorescent carbon quantum dots（CQDs）were synthesized by one-step method using rapeseed and water as raw material.The experiments showed that potassium permanganate（KMnO4）could effectively quench the fluorescence of the CQDs.However

the fluorescence of CQDs-KMnO4 system restored reversibly in the presence of minocycline hydrochloride.Based on this principle

a new method was proposed for the determination of minocycline hydrochloride with the“off-on”fluorescence signal of rapeseed CQDs as a fluorescent probe.Under the optimum conditions

the linear range of the method was 5.0×10-7 mol/L to 1.0×10-5 mol/L with a correlation coefficient of 0.999 5 and a detection limit of 4.9×10-7 mol/L.The method was used in the determination of minocycline hydrochloride in samples with a recovery of 99.6%-100%.The mechanisms for CQDs fluorescence quenched by KMnO4 and recovered by minocycline hydrochloride were studied.

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