To evaluate the migration of treemoss flavoring compounds in slim cigarettes from cut tobaaco to tobacco smoke

a gas chromatography–mass spectrometry(GC-MS) in selected ion monitoring mode was developed for the determination of orcinol monomethyl

orcinol

methyl atratate

ethyl hexadecanoate and ethyl orsellinate in cut tobacco and tobacco smoke.The influences of solvent

extraction time and matrix effect were investigated.The tobacco sample was extracted with ethyl acetate

and quantified externally with matrix matched standard solution.Under the optimized conditions

there were good linear relationships for 5 selected analytes in the range of 0.02-2.0 mg/L with their correlation coefficients(r2) larger than 0.996For cut tobacco

the limits of detection(LODs) and limits of quantitation(LOQs) were in the ranges of 0.79-30 ng/mL and 2.6-10.0 ng/mL

respectively

with spiked recoveries of 90.5%-103% and relative standard deviations(RSDs

n=6) of 2.3%-12%.For tobacco smoke

LODs and LOQs were in the ranges of 0.60-2.9 ng/mL and 2.0-9.6 ng/mL

respectively

with average spiked recoveries of 856%-104% and RSDs(n=6) of 1.6%-9.3%.The proposed method was applied in the determination of 5 analytes in cut tobacco and tobacco smoke followed by the evaluation of the migration of treemoss components from cut tobacco to tobacco smoke.The results showed that the method was handy

sensitive and reliable

and could satisfy the requirements for the determination of the 5 analytes both in cut tobacco and tobacco smoke.