A novel electrochemiluminescence(ECL) method was developed for the sensitive detection of methimazole based on the fact that in the alkaline medium

the weak ECL signal of luminol could be significantly enhanced by a little amount of methimazole on the surface of graphene modified glass carbon electrode.The effects of reaction medium

graphene dosage

luminol concentration and electrochemical scanning rates on ECL signal of the selected system were investigated.Results showed that under the optimal contions of 8.0 μL of graphene amount

0.01 mol·L-1 of sodium hydroxide

0.7 μmol·L-1 of luminol and 100 mV/s of electrochemical scaning rate

the increased ECL intensity for methimazole was linear in the concentration range of 6.0×10-8-1.0×10-5 mol·L-1 with a detection limit of 2.0×10-8 mol·L-1 and a relative standard deviation(RSD) of 3.5%(c=0.5 μmol·L-1

n=11).The proposed method could be applied in the clinical analysis of methimazole tablets with satisfactory results.