Design of Triple Quadrupole Mass Spectrometry Control System Based on NI Development Platform

王晓俊; 孙传强; 龚子珊; 张涛; 杨茹; 赵学玒; 汪曣

doi:doi：10.3969/j.issn.1004-4957.2019.01.004

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Design of Triple Quadrupole Mass Spectrometry Control System Based on NI Development Platform

- Design of Triple Quadrupole Mass Spectrometry Control System Based on NI Development Platform
- Vol. 38, Issue 1, Pages: 31-38(2019)
- 作者机构：
  
  1. 天津大学精密仪器与光电子工程学院
  2. 天津大学天津市生物医学检测技术与仪器重点实验室
- 作者简介：
- 基金信息：
- DOI：doi：10.3969/j.issn.1004-4957.2019.01.004
  CLC：
- Published：2019
- 稿件说明：
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王晓俊, 孙传强, 龚子珊, 张涛, 杨茹, 赵学玒, 汪曣. Design of Triple Quadrupole Mass Spectrometry Control System Based on NI Development Platform[J]. 2019, 38(1): 31-38.
DOI：

王晓俊, 孙传强, 龚子珊, 张涛, 杨茹, 赵学玒, 汪曣. Design of Triple Quadrupole Mass Spectrometry Control System Based on NI Development Platform[J]. 2019, 38(1): 31-38. DOI： doi：10.3969/j.issn.1004-4957.2019.01.004.

摘要

三重四极杆质谱作为生物小分子分析与定量工具被广泛应用。该文基于NI开发平台，利用LabVIEW软件开发了一套质谱控制系统。该系统硬件由PXIe板卡及部分辅助电路组成，实现了气路控制、真空控制、温度控制、扫描电路控制等功能。其中气体流量控制精度为0.1%

真空系统压力为10-3 Pa

温度控制范围为0~850 ℃，温度控制精度为±0.5 ℃。使用该控制系统测试环孢霉素A(Cyclosporine A，CsA)标准样品，获得了CsA样品质谱图，结果发现，质量数为1 202.8 Da的离子峰半峰宽为044 amu。该控制系统具有较好的通用性、可扩展性及维护性，采用面向对象的编程设计，使软硬件分离，降低了软件对硬件的依赖，可满足仪器的使用要求。

Abstract

A control system for triple quadrupole mass spectrometry(TQMS) was developed using LabVIEW software based on the NI development platform as it was widely used as an analysis and quantification tool for small molecules.The system hardware consisted of a PXIe board and some auxiliary circuits

which could realize the functions of air control

vacuum control

temperature control and scanning circuit control.The accuracy for gas flow control was 0.1%

the vacuum system pressure was 10-3 Pa

and the range and accuracy for temperature control were 0-850 ℃ and ±0.5 ℃

respectively.The control system was used for the determination of a cyclosporine A(CsA) standard sample

and a mass spectrum for the CsA sample was obtained.The half width for the ion peak with a mass number of 1 202.8 Da was 0.44 amu.Results showed that the control system

with good versatility

scalability and maintainability

could meet the requirements of the instrument by using object-oriented programming design

separating hardware from software to reduce the dependence of the software on the hardware.

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