Determination of Benvitimod in Cream Cosmetics by QuEChERS/Gas Chromatography－Tandem Mass Spectrometry

LIANG Zi-yang; LUO Hui-tai; ZHOU Xi; LIN Xiao-shan; WU Hui-qin; HUANG Fang

doi:10.19969/j.fxcsxb.23021002

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Determination of Benvitimod in Cream Cosmetics by QuEChERS/Gas Chromatography－Tandem Mass Spectrometry

Experimental Techniques and Methods | 更新时间：2023-06-15

- Determination of Benvitimod in Cream Cosmetics by QuEChERS/Gas Chromatography－Tandem Mass Spectrometry
- Journal of Instrumental Analysis Vol. 42, Issue 6, Pages: 762-767(2023)
- 作者机构：
  
  广东省科学院测试分析研究所（中国广州分析测试中心），广东省化学测量与应急检测技术重点实验室，广东省中药质量安全工程技术研究中心，广东广州 510070
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.23021002
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梁梓洋,罗辉泰,周熙等.QuEChERS/气相色谱－串联质谱法测定膏霜类化妆品中本维莫德[J].分析测试学报,2023,42(06):762-767.

LIANG Zi-yang,LUO Hui-tai,ZHOU Xi,et al.Determination of Benvitimod in Cream Cosmetics by QuEChERS/Gas Chromatography－Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2023,42(06):762-767.
梁梓洋,罗辉泰,周熙等.QuEChERS/气相色谱－串联质谱法测定膏霜类化妆品中本维莫德[J].分析测试学报,2023,42(06):762-767. DOI： 10.19969/j.fxcsxb.23021002.

LIANG Zi-yang,LUO Hui-tai,ZHOU Xi,et al.Determination of Benvitimod in Cream Cosmetics by QuEChERS/Gas Chromatography－Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2023,42(06):762-767. DOI： 10.19969/j.fxcsxb.23021002.

摘要

该文基于QuEChERS法结合气相色谱－串联质谱法（GC－MS/MS），建立了测定膏霜类化妆品中非法添加本维莫德的方法。样品经饱和氯化钠溶液分散后乙腈提取，无水硫酸镁、PSA和C,18,组成的净化剂净化后，以Agilent VF－17ms毛细管柱（30 m × 0.25 mm × 0.25 μm）分离，在选择反应监测（SRM）模式下检测，以基质匹配外标法定量。通过考察提取溶剂种类、提取溶剂体积、提取时间、净化剂组成及用量对本维莫德回收率的影响，确定最优前处理方法。在优化条件下，本维莫德在1 ~ 100 μg/L范围内呈良好线性关系，相关系数（,r,2,）为0.999 5；方法检出限为0.005 μg/g，方法定量下限为0.02 μg/g，目标物的加标回收率为90.0% ~ 96.3%，重复性相对标准偏差（RSD，,n ,= 6）为1.5% ~ 2.7%，日内和日间精密度（RSD）均小于10%。采用该方法对采集的90个膏霜样品进行检测，检出1个阳性样品。该方法具有简便、快速、准确及灵敏的优点，可为打击化妆品非法添加和保障化妆品的质量安全提供技术支撑。

Abstract

A method of QuEChERS/gas chromatography－tandem mass spectrometry（GC－MS/MS） was established for the determination of benvitimod added illegally in cream cosmetics．Cream samples were dispersed with saturated sodium chloride solution and extracted with acetonitrile．After purified with anhydrous magnesium sulfate，PSA and C,18,，the pretreatment samples were separated on an Agilent VF－17ms capillary column（30 m × 0.25 mm × 0.25 μm），detected by GC－MS/MS in selective reaction monitoring（SRM） mode，and quantified by the matrix-matched calibration．The pretreatment method was optimized by investigating the effects of type and volume of extraction solvent，extraction time，purification composition and dosage on the recovery of benvitimod．Under the optimal conditions，benvitimod showed a good linear relationship in the concentration range of 1－100 μg/L with a correlation coefficient（,r,2,） of 0.999 5．The limit of detection was 0.005 μg/g，and the limit of quantitation was 0.02 μg/g．The spiked recoveries for the target substance ranged from 90.0% to 96.3%，with relative standard deviations（RSDs，,n ,= 6） for repeatability of 1.5%－2.7%，and inter-RSDs and intra-RSDs both less than 10%．The method was applied to the determination of 90 cream cosmetics containing plant extracts，in which one positive sample was found．This method is convenient，accurate and sensitive，and it could provide a technical support for combating illegal addition of cosmetics and ensuring the quality and safety of cosmetics.

关键词

气相色谱－串联质谱（GC－MS/MS）分散固相萃取化妆品非法添加本维莫德

Keywords

gas chromatography－tandem mass spectrometry（GC－MS/MS）dispersed solid phase extractioncosmeticsillegal additionbenvitimod

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中国广州分析测试中心广东省化学危害应急检测技术重点实验室

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