A microwave digestion inductively coupled plasma mass spectrometry（ICP－MS） was developed for the determination of metal elements in blood samples．The digestion conditions were optimized，bismuth（Bi） and indium（In） were used as the double internal standard calibration to detect the content of metal elements in postmortem human blood samples and general population control samples．Meanwhile，statistical methods were used to compare the difference and correlation．The results showed that under the digestion conditions of 2 mL hydrogen peroxide，5 mL nitric acid and 190 ℃，the digestion effect was better．There were good linear relationships for nine elements，including magnesium（Mg），chromium（Cr），arsenic（As），strontium（Sr），cadmium（Cd），barium（Ba），mercury（Hg），thallium（Tl） and lead（Pb），with their correlation coefficients（,r,2,） not less than 0.997 7，and the detection limits of 0.000 4－0.049 6 ng/mL．The spiked recoveries ranged from 86.5% to 110%，with the intra-day relative standard deviations（RSDs） and the inter-day RSDs of 0.50%－5.9% and 2.5%－8.5%，respectively，indicating that the recoveries and the precision meet the detection requirements．The Mann－Whitney U test was used to compare the two groups of data since the data of nine metal elements do not conform to Komogorov－Smirnov normality test，and the difference was significant（,P ,<, 0.05）．Spearman rank correlation was used to analyze the correlation among metals，and it was found that most metal elements were significantly correlated．A binary logistic regression model was established to investigate the odds ratio（OR） and 95% confidence interval of the sample type and the concentration of metal elements in the blood sample．Mg，Cd and Ba elements were included in the logistic regression model simultaneously．It was found that the results of Mg element were not statistically significant（,P ,>, 0.05），Cd and Ba elements were related to the type of blood sample．The detection method and basic data established in this paper could provide important reference and scientific data support for detection and identification of cases related to forensic metal element poisoning.