Rapid Screening of Prostaglandin F2α Compounds in Eyelash Cosmetics by Ultra-performance Liquid Chromatography－ Quadrupole Time-of-flight Mass Spectrometry

WANG Xin-ran; YIN Wei-cheng; WANG Hai-yan; LU Yong

doi:10.19969/j.fxcsxb.22080101

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Rapid Screening of Prostaglandin F2α Compounds in Eyelash Cosmetics by Ultra-performance Liquid Chromatography－ Quadrupole Time-of-flight Mass Spectrometry

Scientific Papers | 更新时间：2023-05-25

- Rapid Screening of Prostaglandin F2α Compounds in Eyelash Cosmetics by Ultra-performance Liquid Chromatography－ Quadrupole Time-of-flight Mass Spectrometry
- Journal of Instrumental Analysis Vol. 42, Issue 1, Pages: 55-61(2023)
- 作者机构：
  
  1.中国食品药品检定研究院/国家药品监督管理局化妆品研究与评价重点实验室，北京 100050
  2.湖南省药品检验检测研究院，湖南长沙 410001
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.22080101
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王欣然,尹伟成,王海燕等.超高效液相色谱－四极杆飞行时间质谱法快速筛查睫毛用化妆品中前列腺素F2α类化合物[J].分析测试学报,2023,42(01):55-61.

WANG Xin-ran,YIN Wei-cheng,WANG Hai-yan,et al.Rapid Screening of Prostaglandin F2α Compounds in Eyelash Cosmetics by Ultra-performance Liquid Chromatography－ Quadrupole Time-of-flight Mass Spectrometry[J].Journal of Instrumental Analysis,2023,42(01):55-61.
王欣然,尹伟成,王海燕等.超高效液相色谱－四极杆飞行时间质谱法快速筛查睫毛用化妆品中前列腺素F2α类化合物[J].分析测试学报,2023,42(01):55-61. DOI： 10.19969/j.fxcsxb.22080101.

WANG Xin-ran,YIN Wei-cheng,WANG Hai-yan,et al.Rapid Screening of Prostaglandin F2α Compounds in Eyelash Cosmetics by Ultra-performance Liquid Chromatography－ Quadrupole Time-of-flight Mass Spectrometry[J].Journal of Instrumental Analysis,2023,42(01):55-61. DOI： 10.19969/j.fxcsxb.22080101.

摘要

采用超高效液相色谱－四极杆飞行时间质谱（UPLC－Q－TOF MS/MS）技术，建立了睫毛用化妆品中9种前列腺素F2α类化合物（比马前列素、曲伏前列素、他氟前列素、他氟乙酰胺、拉坦前列素、比马前列素酸甲基酯、氯前列醇异丙基酯、15-酮-曲伏前列素、比马酰胺）的快速定性筛查方法。样品经乙腈超声提取，采用Waters ACQUITY UPLC BEH C,18,（2.1 mm × 100 mm，1.7 μm）色谱柱，以2 mmol/L甲酸铵水溶液（含0.05%甲酸）－乙腈为流动相，分离后进入四极杆飞行时间质谱，采用电喷雾离子源正离子模式（ESI+），以MS,E,模式进行数据采集，建立了9种前列腺素F2α类化合物的筛查数据库。9种化合物在各自质量浓度范围内线性关系良好，相关系数（,r,2,）均大于0.99，检出限为0.075 ~ 0.75 μg/g，定量下限为0.25 ~ 2.5 μg/g。所建立的筛查数据库无需对照品即可对化妆品中的9种前列腺素F2α类化合物进行筛查。结果表明，该方法特异性良好，应用于48批睫毛类化妆品的定性筛查具有良好的选择性，可为化妆品中前列腺素F2α类化合物的筛查分析提供技术支持。

Abstract

A high-throughput method for rapid and qualitative screening of nine prostaglandin F2α compounds，i.e. bimatoprost，travoprost，tafluprost，tafluprost ethyl amide，latanoprost，bimatoprost acid methyl ester，cloprostenol isopropyl ester，15-keto travoprost，N-norbimatoprost in eyelash cosmetics was established by ultra-performance liquid chromatography－quadrupole time-of-flight mass spectrometry（UPLC－Q－TOF MS/MS）．The samples were ultrasonically extracted with acetonitrile，separated on a Waters ACQUITY UPLC BEH C,18,（2.1 mm × 100 mm，1.7 μm） chromatographic column with 2 mmol/L ammonium formate aqueous solution containing 0.05% formic acid－acetonitrile as the mobile phase，then data-acquisitioned by quadrupole time-of-flight mass spectrometry in MS,E, mode using electrospray ionization source in positive ion mode（ESI+），and a high-throughput screening database for 9 prostaglandin F2α compounds was established．There were good linear relationships for the 9 analytes in their respective concentration ranges，with correlation coefficients（,r,2,） all greater than 0.99．The detection limits and the quantitation limts of 9 analytes were in the ranges of 0.075－0.75 μg/g and 0.25－2.5 μg/g，respectively．The screening database collected and established by high-resolution mass spectrometry can screen 9 kinds of prostaglandin F2α compounds in cosmetics without reference substances．The results showed that the established method has good selectivity in high-throughput qualitative screening of 48 batches of eyelash cosmetics with good specificity．The method is suitable for the screening and analysis of prostaglandin F2α compounds in cosmetics，and it could provide a technical support for the qualitative analysis of five prostaglandin F2α compounds in cosmetics.

关键词

前列腺素F2α化妆品超高效液相色谱－四极杆飞行时间质谱

Keywords

prostaglandin F2αcosmeticsultra-performance liquid chromatography－quadrupole time-of-flight mass spectrometry

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