Determination of Migration of Ethyleneimine in Food Contact Paper and Paper Product by Ultra-high Performance Liquid Chromatography－Tandem Mass Spectrometry

LI Zi-cheng; ZHANG Hai-feng; LIANG Jin-xin; DONG Ben; CHEN Yan-fen; ZENG Ying; CHEN Sheng; ZHONG Huai-ning; LI Dan; ZHENG Jian-guo

doi:10.19969/j.fxcsxb.22071204

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Determination of Migration of Ethyleneimine in Food Contact Paper and Paper Product by Ultra-high Performance Liquid Chromatography－Tandem Mass Spectrometry

Experimental Techniques and Methods | 更新时间：2023-01-04

- Determination of Migration of Ethyleneimine in Food Contact Paper and Paper Product by Ultra-high Performance Liquid Chromatography－Tandem Mass Spectrometry
- Journal of Instrumental Analysis Vol. 41, Issue 10, Pages: 1553-1557(2022)
- 作者机构：
  
  广州海关技术中心，广东广州 510623
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- DOI：10.19969/j.fxcsxb.22071204
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黎梓城,张海峰,梁进欣等.超高效液相色谱－串联质谱法测定食品接触用纸和纸制品中乙烯亚胺的迁移量[J].分析测试学报,2022,41(10):1553-1557.

LI Zi-cheng,ZHANG Hai-feng,LIANG Jin-xin,et al.Determination of Migration of Ethyleneimine in Food Contact Paper and Paper Product by Ultra-high Performance Liquid Chromatography－Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2022,41(10):1553-1557.
黎梓城,张海峰,梁进欣等.超高效液相色谱－串联质谱法测定食品接触用纸和纸制品中乙烯亚胺的迁移量[J].分析测试学报,2022,41(10):1553-1557. DOI： 10.19969/j.fxcsxb.22071204.

LI Zi-cheng,ZHANG Hai-feng,LIANG Jin-xin,et al.Determination of Migration of Ethyleneimine in Food Contact Paper and Paper Product by Ultra-high Performance Liquid Chromatography－Tandem Mass Spectrometry[J].Journal of Instrumental Analysis,2022,41(10):1553-1557. DOI： 10.19969/j.fxcsxb.22071204.

摘要

采用超高效液相色谱－串联质谱（UPLC－MS/MS）建立了食品接触用纸和纸制品中乙烯亚胺迁移量的测定方法。以0.1%（体积分数）甲酸水溶液和甲醇作为流动相，使用电喷雾离子源对目标物进行电离，采用多反应监测模式进行测定。结果表明，乙烯亚胺在4%乙酸、10%乙醇、95%乙醇与异辛烷模拟物中的线性范围为0.003 ~ 0.05 mg/L，检出限为1 μg/L；在橄榄油模拟物中的线性范围为0.003 ~ 0.05 mg/kg，检出限为1 μg/kg。各食品模拟物中，乙烯亚胺的加标回收率为96.0% ~ 102%，相对标准偏差（RSD）为1.6% ~ 5.9%。采用该方法对20批次实际样品进行检测，有2批次检出乙烯亚胺。该方法简单快速，具有较高的准确性、灵敏度，适用于食品接触用纸和纸制品中乙烯亚胺迁移量的检测。

Abstract

An analytical method for migration amount of ethyleneimine in food contact paper and paper product was established by ultra-high performance liquid chromatography－tandem mass spectrometry（UPLC－MS/MS）．Formic acid aqueous solution（0.1%，volume fraction） and methanol were adopted as mobile phases，electrospray ionization（ESI） ion source was used to ionize the target，and multi-reaction monitoring mode was ultilized for detection．The results showed that there was good linear relationships for ethyleneimine in simulants of 4% acetic acid，10% ethanol，95% ethanol and isooctane in the mass concentration range of 0.003－0.05 mg/L，with the detection limits of 1 μg/L．Meanwhile，good linear relationship for ethyleneimine in simulant of olive oil existed in the range of 0.003－0.05 mg/kg，with a detection limit of 1 μg/kg．The spiked recoveries ranged from 96.0% to 102%，with the relative standard deviations（RSDs） of 1.6%－5.9%．20 batches of samples were selected for practical detection，of which 2 batches were found to contain ethyleneimine．The method was sensitive and accurate，and it was suitable for the determination of migration of ethyleneimine in food contact paper and paper products.

关键词

乙烯亚胺迁移量食品接触用纸超高效液相色谱-串联质谱法

Keywords

ethyleneiminemigrationfood contact materialultra-high performance liquid chromatography－tandem mass spectrometry

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Zhejiang Institute of Product Quality and Safety Science

Zhejiang University of Science ＆ Technology

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