Simultaneous Determination of Specific Migration Amounts of 15 N-nitrosamines in Food Contact Materials and Products by Gas Chromatography－Thermal Energy Analyzer with Alcoholic Food Simulants

LIN Rui; XU Dun-ming; HUANG Yi-jue; DONG Qing-mu; LAI Ying; YANG Zi-he; YANG Ze; ZHUANG Li-li; GUO Si-li; WU Yi-feng; LIN Wei-jing; LIN Hai-xia; DING Hua-jun; SHEN Lu-hong; TU Xing-peng

doi:10.19969/j.fxcsxb.22071001

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Simultaneous Determination of Specific Migration Amounts of 15 N-nitrosamines in Food Contact Materials and Products by Gas Chromatography－Thermal Energy Analyzer with Alcoholic Food Simulants

Experimental Techniques and Methods | 更新时间：2023-01-04

- Simultaneous Determination of Specific Migration Amounts of 15 N-nitrosamines in Food Contact Materials and Products by Gas Chromatography－Thermal Energy Analyzer with Alcoholic Food Simulants
- Journal of Instrumental Analysis Vol. 41, Issue 10, Pages: 1542-1547(2022)
- 作者机构：
  
  厦门海关技术中心，福建厦门 361026
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.22071001
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林睿,徐敦明,黄旖珏等.气相色谱－热能分析仪法同时测定食品接触材料及制品中15种N-亚硝胺在酒精类食品模拟物中的迁移量[J].分析测试学报,2022,41(10):1542-1547.

LIN Rui,XU Dun-ming,HUANG Yi-jue,et al.Simultaneous Determination of Specific Migration Amounts of 15 N-nitrosamines in Food Contact Materials and Products by Gas Chromatography－Thermal Energy Analyzer with Alcoholic Food Simulants[J].Journal of Instrumental Analysis,2022,41(10):1542-1547.
林睿,徐敦明,黄旖珏等.气相色谱－热能分析仪法同时测定食品接触材料及制品中15种N-亚硝胺在酒精类食品模拟物中的迁移量[J].分析测试学报,2022,41(10):1542-1547. DOI： 10.19969/j.fxcsxb.22071001.

LIN Rui,XU Dun-ming,HUANG Yi-jue,et al.Simultaneous Determination of Specific Migration Amounts of 15 N-nitrosamines in Food Contact Materials and Products by Gas Chromatography－Thermal Energy Analyzer with Alcoholic Food Simulants[J].Journal of Instrumental Analysis,2022,41(10):1542-1547. DOI： 10.19969/j.fxcsxb.22071001.

摘要

建立了气相色谱－热能分析仪法（GC－TEA）同时测定食品接触材料及制品中15种N-亚硝胺在酒精类食品模拟物中迁移量的方法。对气相色谱条件、前处理方法（液液萃取法）进行优化，以10%乙醇、20%乙醇、50%乙醇作为食品模拟物，浸泡液经稀释、液液萃取、浓缩、DB－FFAP色谱柱分离后，采用热能分析仪进行检测，外标法定量。在优化实验条件下，15种N-亚硝胺实现了良好的基线分离，线性范围为0.025 ~ 0.5 mg/L，相关系数（,r,2,）大于0.998，检出限（LOD）为0.200 μg/kg，定量下限（LOQ）为0.625 μg/kg。加标回收率为85.7% ~ 106%，相对标准偏差（RSD）小于10%。该方法具有操作简单、线性范围好、灵敏度和准确度高等优点，适用于食品接触材料及制品中15种N-亚硝胺迁移量的检测。

Abstract

A gas chromatography－thermal energy analyzer（GC-TEA） method with alcoholic food simulants was established for the simultaneous determination on the migration amounts of 15 N-nitrosamines in food contact materials and products．The gas chromatographic conditions and pretreatment method（liquid－liquid extraction method） were optimized．Using 10% ethanol，20% ethanol and 50% ethanol as food simulants，the immersion solution was diluted，liquid－liquid extracted and concentrated，then separated on a DB－FFAP column，and finally detected by the thermal energy analyzer and quantified by the external standard method．Under the optimized experimental conditions，good baseline separation for 15 N-nitrosamines was achieved in the linear range of 0.025－0.5 mg/L，with correlation coefficients（,r,2,） greater than 0.998．The limits of detection（LODs） and limits of quantitation（LOQs） were 0.200 μg/kg and 0.625 μg/kg，respectively．The spiked recoveries ranged from 85.7% to 106%，with relative standard deviations（RSDs） less than 10%．With the advantages of simple operation，good linear range，high sensitivity and accuracy，the method was suitable for the determination of 15 N-nitrosamines in food contact materials and products．

关键词

食品接触材料及制品N-亚硝胺酒精类食品模拟物特殊迁移量气相色谱－热能分析仪法（GC－TEA）

Keywords

food contact materials and productsN-nitrosaminesalcoholic food simulantsspecific migration amountsgas chromatography－thermal energy analyzer（GC－TEA）

references

HG/T 2946－2011. Rubber Nipple. Chemical Industry Standard of the People's Republic of China（橡胶奶头．中华人民共和国化工行业标准）.

GB 28482－2012. Safety Requirements of Soothers for Babies and Young Children. National Standards of the People's Republic of China（婴幼儿安抚奶嘴安全要求．中华人民共和国国家标准）.

GB 4806.2－2015. National Food Safety Standard－Nipple. National Standards of the People's Republic of China（食品安全国家标准奶嘴．中华人民共和国国家标准）.

EN 12868－2017. Child Use and Care Articles－Method for Determining the Release of N-Nitrosamines and N-Nitrosatable Substances from Elastomer or Rubber Teats and Soothers. European Committee for Standardization.

GB 4806.11. National Food Safety Standard－Rubber Materials and Products for Food Contact. National Standards of the People's Republic of China（食品安全国家标准．食品接触用橡胶材料及制品．中华人民共和国国家标准）.

Xian Q M，Huang P L．J. Instrum. Anal. （鲜启明，黄沛力．分析测试学报），2008，27（4）：445－447.

Cai J A，Liu Z J，Yuan J W，Pan Y H，Ye Y J．J. Instrum. Anal. （蔡锦安，刘志健，袁嘉伟，潘永红，叶元坚．分析测试学报），2016，35（2）：245－248.

GB/T 24153－2009. Rubber and Elastomer Materials－Determination of N-Nitrosamines. National Standards of the People's Republic of China（橡胶及弹性体材料 N-亚硝基胺的测定．中华人民共和国国家标准）.

GB/T 29669－2013. Determination of 10 Volatile Nitrosamines Including N-Nitrosodimethylamine in Cosmetics－Gas Chromatography Tandem Mass Spectrometry．National Standards of the People's Republic of China（化妆品中N-亚硝基二甲基胺等10种亚硝胺的测定－气相色谱－质谱/质谱法．中华人民共和国国家标准）.

GB/T 39183－2020. Determination of the Migration Quantity of Nitrosamines in Consumer Products－Gas Chromatography－Tandem Mass Spectrometry. National Standards of the People's Republic of China（消费品中亚硝胺迁移量的测定气相色谱－串联质谱法．中华人民共和国国家标准）.

Xing Y N，Wang X，Chen Z Y，Lin H X．J. Instrum. Anal. （幸苑娜，王欣，陈泽勇，林浩学．分析测试学报），2012，31（7）：779－884.

Zhang J，Zeng M S，Lai J M，Li S Y，Yan X H，Ding Y．J. Instrum. Anal.（张静，曾敏珊，赖俊敏，李思源，严小红，丁怡．分析测试学报），2022，41（6）：916－920.

GB/T 35956－2018. Detection and Determination of N-Nitrosodiethanolamine（NDELA） in Cosmetics－HPLC－MS/MS．National Standards of the People's Republic of China

化妆品中N-亚硝基二乙醇胺（NDELA）的测定－高效液相色谱－串联质谱法．中华人民共和国国家标准.

GB 31604.1－2015. National Food Safety Standard－General Rules for Migration Test of Food Contact Materials and Products. National Standard of the People's Republic of China（食品安全国家标准食品接触材料及制品迁移试验通则．中华人民共和国国家标准）.

GB 5009.156－2016. National Food Safety Standard－General Rules of the Migration Test Pretreatment Methods of Food Contact Materials and Articles. National Standard of the People's Republic of China（食品安全国家标准食品接触材料及制品迁移试验预处理方法通则．中华人民共和国国家标准）.

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