Migration Test and Risk Assessment Based on Dietary Exposure of PBT/PET Cyclic Oligomers in Polymer-laminated Metal Cans

LI Qian-yun; WU Gang; WANG Ya; WANG Xiao-long; PAN Feng; ZHANG Hong; XING Hang; LI Jian-wen; ZHU Lei

doi:10.19969/j.fxcsxb.22070203

您当前的位置：

首页 >

文章列表页 >

Migration Test and Risk Assessment Based on Dietary Exposure of PBT/PET Cyclic Oligomers in Polymer-laminated Metal Cans

Scientific Papers | 更新时间：2023-01-04

- Migration Test and Risk Assessment Based on Dietary Exposure of PBT/PET Cyclic Oligomers in Polymer-laminated Metal Cans
- Journal of Instrumental Analysis Vol. 41, Issue 10, Pages: 1494-1500(2022)
- 作者机构：
  
  1.国家食品安全风险评估中心，北京 100022
  2.中国食品发酵工业研究院，北京 100015
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.22070203
  CLC：
扫描看全文
李倩云,吴刚,王亚等.覆膜金属罐中PBT/PET环状低聚物在食品中的迁移测试及基于膳食暴露量的风险评估[J].分析测试学报,2022,41(10):1494-1500.

LI Qian-yun,WU Gang,WANG Ya,et al.Migration Test and Risk Assessment Based on Dietary Exposure of PBT/PET Cyclic Oligomers in Polymer-laminated Metal Cans[J].Journal of Instrumental Analysis,2022,41(10):1494-1500.
李倩云,吴刚,王亚等.覆膜金属罐中PBT/PET环状低聚物在食品中的迁移测试及基于膳食暴露量的风险评估[J].分析测试学报,2022,41(10):1494-1500. DOI： 10.19969/j.fxcsxb.22070203.

LI Qian-yun,WU Gang,WANG Ya,et al.Migration Test and Risk Assessment Based on Dietary Exposure of PBT/PET Cyclic Oligomers in Polymer-laminated Metal Cans[J].Journal of Instrumental Analysis,2022,41(10):1494-1500. DOI： 10.19969/j.fxcsxb.22070203.

摘要

该文建立了一种超高效液相色谱－四极杆飞行时间质谱联用技术（UPLC－QTOF MS）测定覆膜金属罐包装食品中聚对苯二甲酸乙二醇酯（PET）和聚对苯二甲酸丁二醇酯（PBT）环状低聚物迁移量的方法。利用我国人群食物消费量、与食品接触面积和食品单位质量/体积比（,S,/,V,）的调查数据以及PET和PBT环状低聚物迁移试验数据，估算了我国人群对摄入的水果罐头、饮料和啤酒等以覆膜金属罐包装食品中PET和PBT环状低聚物的膳食暴露量，并按照毒理学关注阈值（TTC）决策树方法对其进行风险评估。结果显示，6种PET和PBT环状低聚物均属于Cramer Ⅲ类结构；其膳食暴露量最大值为1.234 µg/kg·BW/d，低于Cramer Ⅲ类物质的阈值1.5 µg/kg·BW/d。表明通过摄入覆膜金属罐包装的水果罐头、饮料和啤酒暴露于PBT和PET环状低聚物所引起的健康风险较低。

Abstract

The cyclic oligomers may migrate from polyethylene terephthalate（PET） and polybutylene terephthalate（PBT） coating of metal cans to foods，which may do harm to the human health．Hence，a method was developed for the detection of migration content of PBT/PET cyclic oligomers in coating of metal cans by ultra-high performance liquid chromatography－quadrupole time-of-flight mass spectrometry（UPLC－QTOF MS）．According to the database of food consumption，the surface to volume（,S,/,V,） data of food contact materials and the migration tests of PET and PBT cyclic oligomers，the total intake of PET and PBT cyclic oligomers in chinese people exposing to coating of metal cans（fruit cans，drinks cans and beer cans） was estimated，and its risk was assessed by threshold of toxicological concern．Six kinds of PET and PBT cyclic oligomers belonged to the substances of Cramer Ⅲ．The maximum dietary exposure contents of PET and PBT cyclic oligomers were both 1.234 µg/kg·BW/d，which were lower than 1.5 µg/kg·BW/d，the threshold of substances of Cramer Ⅲ．As a result，the intake health risk of PET and PBT cyclic oligomers exposing on coating of metal cans（fruit cans，drinks cans and beer cans） was low，which required no undue attention.

关键词

聚对苯二甲酸乙二醇酯（PET）聚对苯二甲酸丁二醇酯（PBT）环状低聚物覆膜金属罐迁移测试毒理学关注阈值（TTC）风险评估

Keywords

polyethylene terephthalate（PET）polybutylene terephthalate（PBT）cyclic oligomerspolymer-laminated metal cansmigration testthreshold of toxicological concern（TTC）risk assessment

references

Song W W，Wang J Q，Bai J G，Zhao Y H．China Packag. Ind. 宋伟伟，王洁琼，柏建国，赵宇晖．中国包装工业），2015，（21）：73－75.

Zhang Q，Guo W Y，Ding S M，Chen J Y．Shanghai Packag. 张清，郭文渊，丁树民，陈晋阳．上海包装），2017，（4）：58－61.

Zhang Q D，Liu J Y，Zhang B Y，Zhang L Y．J. Mech. Eng. （张清东，刘吉阳，张勃洋，张立元．机械工程学报），2019，55（8）：30－45.

Liu Z H，Zeng K，Zhao Y H．Packag. J. （刘志浩，曾科，赵宇晖．包装学报），2012，4（4）：9－15.

Han M H，Jegal J P，Park K W，Choi J H，Baik H K，Noh J H，Song K M，Lim Y S．Surf. Coat. Technol.，2007，（201）：4948－4952．

Zumelzu E，Cabezas C，Delgado F．J. Mater. Process. Technol.，2004，152（3）：384－388.

Hoppe M，Voogt P D，Franz R．Trends Food Sci. Technol.，2016，50（1）：118－130.

GB 9685－2016. National Food Safety Standard. Standard for Use of Additives in Food Contact Materials and Articles. National Standard of the People’s Republic of China（食品安全国家标准．食品接触材料及制品用添加剂使用标准．中华人民共和国国家标准）.

GB 4806.6－2016. National Food Safety Standard. Food Contact Plastic Resin. National Standard of the People’s Republic of China（食品安全国家标准．食品接触用塑料树脂．中华人民共和国国家标准）.

GB 4806.1－2016. National Food Safety Standard. General Safety Requirements for Food Contact Materials and Products. National Standard of the People’s Republic of China（食品安全国家标准．食品接触材料及制品通用安全要求．中华人民共和国国家标准）.

Xu T T，Qiu K，Gao H B，Wu G，Zhang B L，Zhao Q Q，Zhang Y L．Food Control，2021，130（2）：108396.

Emmanouil D，Joao A L，Oliver K，Thomas T，Eddo J．Food Chem.，2020，317（1）：1－11.

EFSA Scientific Committee．EFSA J.，2012，10（7）：1－103.

European Commission. Joint research centre. Varese：European Commission，［2022－05－28］. http：//ihcp.jrc.e.europa.eu/our_labs/computational_toxicology/qsar_tools/toxtreehttp://ihcp.jrc.e.europa.eu/our_labs/computational_toxicology/qsar_tools/toxtree．

Li Q Y，Zhang H，Cai Y J，Qian W L，Huang X Y，Yin Y J，Xing H，Zhu L．Chin. J. Food Hyg.

李倩云，张泓，蔡月洁，钱伟玲，黄小玉，殷玉洁，邢航，朱蕾．中国食品卫生杂志），2022，34（1）：11－16.

GB 31604.1－2015. National Food Safety Standard. General Principle for the Migration Test of Food Contact Materials and Their Products. National Standard of the People’s Republic of China（食品安全国家标准．食品接触材料及制品迁移试验通则．中华人民共和国国家标准）.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Risk Assessment and Determination of 18 Alkaloids in Honey by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry

PM_2.5-bound Plastic Additives in Guangzhou，China：Occurrence，Influencing Factors and Risk Assessment

Detection of Leachables in Huoxiang Zhengqi Liquid Based on Fabric Phase Sorptive Extraction and Their Risk Assessment

Non-targeted Screening of Nonvolatile Migration Compounds in Recycled PET Based on Whole Chain and Their Identification of Characteristic Risk Markers

Related Author

No data

Related Institution

Hunan Provincial Center for Disease Control and Prevention

Key Laboratory of Theoretical Chemistry of Environment，Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE，School of Environment，South China Normal University

Faculty of Science，Beijing University of Chemical Technology

School of Basic Medical Sciences，Capital Medical University

College of Chemistry，Beijing University of Chemical Technology

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰