Non-targeted Screening and Risk Assessment of Nonvolatile Migrants in Paper Straws

AN Hao-yue; MA Xin; WANG Qian; SUI Hai-xia; DU Zhen-xia

doi:10.19969/j.fxcsxb.22063003

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Non-targeted Screening and Risk Assessment of Nonvolatile Migrants in Paper Straws

Scientific Papers | 更新时间：2023-01-04

- Non-targeted Screening and Risk Assessment of Nonvolatile Migrants in Paper Straws
- Journal of Instrumental Analysis Vol. 41, Issue 10, Pages: 1478-1485(2022)
- 作者机构：
  
  1.北京化工大学化学学院，北京 100029
  2.国家食品安全风险评估中心，北京 100022
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.22063003
  CLC：
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安皓月,马鑫,王倩等.纸吸管中非挥发性迁移物的非靶向筛查及风险评估[J].分析测试学报,2022,41(10):1478-1485.

AN Hao-yue,MA Xin,WANG Qian,et al.Non-targeted Screening and Risk Assessment of Nonvolatile Migrants in Paper Straws[J].Journal of Instrumental Analysis,2022,41(10):1478-1485.
安皓月,马鑫,王倩等.纸吸管中非挥发性迁移物的非靶向筛查及风险评估[J].分析测试学报,2022,41(10):1478-1485. DOI： 10.19969/j.fxcsxb.22063003.

AN Hao-yue,MA Xin,WANG Qian,et al.Non-targeted Screening and Risk Assessment of Nonvolatile Migrants in Paper Straws[J].Journal of Instrumental Analysis,2022,41(10):1478-1485. DOI： 10.19969/j.fxcsxb.22063003.

摘要

根据欧盟法规推荐的两种食物模拟物对纸吸管样品进行模拟迁移试验，并基于超高效液相色谱－四极杆飞行时间质谱（UPLC－Q－TOF MS）对样品中的迁移物进行非靶向筛查，得到包括润滑剂、施胶剂、抗氧剂降解产物、消泡剂在内的31种有意添加物和非有意添加物。利用该课题组前期建立的风险矩阵，即风险 = 危害（毒性水平 + Cramer分级 + 4 × 致突变性） × 暴露（4 × 水溶性 + 4 × 渗透性），对纸吸管中31种迁移物进行风险分级。结果表明，未发现Ⅰ级高风险物质，Ⅱ级风险物质中得分较高的来自润滑剂（十六酸酰胺等）、施胶剂（海松酸等）和消泡剂（聚乙二醇等）中的成分，对Ⅱ级风险物质进行半定量分析，通过对比暴露量和TTC阈值，发现酰胺类润滑剂（尤其是芥酸酰胺）存在健康风险，应在纸吸管生产加工过程中引起关注。

Abstract

Based on the European Union regulations，paper straw samples were soaked in the two food simulants. Potential migrants in paper straws were untargeted screened by ultrahigh performance liquid chromatography coupled to quadrupole time－of－flight mass spectrometry（UPLC－Q－TOF MS）．Thirty-one kinds of intentionally or non-intentionally added substances including lubricants，sizing agents，antioxidant degradation products and defoaming agents were screened out. Based on the risk matrix developed by our previous study，namely，risk = hazard （toxicity level + Cramer level + 4 × mutagenicity） × exposure （4 × water solubility + 4 × permeability），the risk of thirty-one kinds of migrants in paper straws were evaluated. The result showed that no grade Ⅰ risk substances were found，and components scored higher in grade Ⅱ risk substances were from several lubricants（such as hexadecenoic acid amide），sizing agents （such as pimaric acid） and defoaming agents（such as polyethylene glycol）．Through semi quantitative analysis on grade Ⅱ risk substances，as well as comparison of exposure and TTC threshold，it is found that amide lubricants have health risks，（especially erucamide） which should be paid attention to in the production and processing of paper straws．

关键词

纸吸管食品接触材料超高效液相色谱－四极杆飞行时间质谱（UPLC－Q－TOF MS）非靶向筛查风险矩阵

Keywords

paper strawfood contact materialsultrahigh performance liquid chromatography coupled to quadrupole time－of－flight mass spectrometry（UPLC－Q－TOF MS）non-targeted screeningrisk matrix

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Institute of Analysis and Testing，Beijing Academy of Science and Technology，Beijing Center for Physical and Chemical Analysis

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