A method was developed for the simultaneous determination of six illegally added analgesic drugs，i.e aminopyrine，phenacetin，diclofenac sodium，indometacin，phenylbutazone and chlorpheniramine in cosmetics by ultra-high performance liquid chromatography－tandem mass spectrometry（UHPLC－MS/MS）．Four kinds of cosmetics such as cream，facial mask，gel and spray were selected as the representative matrixes．The sample pretreatment conditions were optimized in detail．The cosmetic samples were firstly extracted with acetonitrile by ultrasonic-assisted liquid－liquid extraction，then separated on an ACQUITY UPLC BEH C,18, column（2.1 mm × 100 mm，1.7 μm） by gradient elution，with acetonitrile and water both containing 5 mmol/L ammonium acetate as the mobile phases at a flow rate of 0.3 mL/min and an injection volume of 10 μL，and finally detected by tandem mass spectrometry under multiple reaction monitoring（MRM） scanning mode．Retention times and charge－mass ratio of the compounds（parent ion and two daughter ions） were used for qualitative analysis．Quantitative analyses were carried out by the matrix standard curves using the peak areas of the daughter ions with higher intensity．The results showed that there were good linear relationships for six compounds in the range of 5－200 μg/L with their correlation coefficients（,r,） larger than 0.99．The limits of detection（LOD） and limits of quantitation（LOQ） of the method were 0.15 μg/g and 0.50 μg/g，respectively．The recoveries at three spiked levels for the six components in four matrixes ranged from 75.0% to 120%，with intra-day relative standard deviations（RSD） not more than 7.9% and inter-day RSD no more than 9.7%．With the advantages of simplicity，high sensitivity and accuracy，this method is suitable for the determination of analgesic chemical components in various cosmetics substrates，and it also provides a technical support for the safety supervision of cosmetics.