Research of Exposure Monitoring for Synthetic Musk among College Students Based on Passive Sampling of Silicone Bracelet and Gas Chromatography-Mass Spectrometry

KE Ming-yan; WANG Hao; WU Fan; ZHANG Zhan-yi; ZHANG Na; MENG Pei-pei

doi:10.12452/j.fxcsxb.24020404

您当前的位置：

首页 >

文章列表页 >

Research of Exposure Monitoring for Synthetic Musk among College Students Based on Passive Sampling of Silicone Bracelet and Gas Chromatography-Mass Spectrometry

Scientific Papers | 更新时间：2024-08-16

- Research of Exposure Monitoring for Synthetic Musk among College Students Based on Passive Sampling of Silicone Bracelet and Gas Chromatography-Mass Spectrometry
- Journal of Instrumental Analysis Vol. 43, Issue 5, Pages: 731-737(2024)
- 作者机构：
  
  暨南大学环境与气候学院广东省环境污染与健康重点实验室，广东广州 511436
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.24020404
  CLC： O657.7;X132
- Published：15 May 2024，
  
  Received：04 February 2024，
  
  Revised：11 March 2024，
- 稿件说明：
扫描看全文
柯铭彦,王浩,吴凡,张展毅,张娜,孟佩佩.基于硅胶腕带被动采样/气相色谱-质谱法的大学生群体合成麝香暴露监测研究[J].分析测试学报,2024,43(05):731-737.

KE Ming-yan,WANG Hao,WU Fan,ZHANG Zhan-yi,ZHANG Na,MENG Pei-pei.Research of Exposure Monitoring for Synthetic Musk among College Students Based on Passive Sampling of Silicone Bracelet and Gas Chromatography-Mass Spectrometry[J].Journal of Instrumental Analysis,2024,43(05):731-737.
柯铭彦,王浩,吴凡,张展毅,张娜,孟佩佩.基于硅胶腕带被动采样/气相色谱-质谱法的大学生群体合成麝香暴露监测研究[J].分析测试学报,2024,43(05):731-737. DOI： 10.12452/j.fxcsxb.24020404.

KE Ming-yan,WANG Hao,WU Fan,ZHANG Zhan-yi,ZHANG Na,MENG Pei-pei.Research of Exposure Monitoring for Synthetic Musk among College Students Based on Passive Sampling of Silicone Bracelet and Gas Chromatography-Mass Spectrometry[J].Journal of Instrumental Analysis,2024,43(05):731-737. DOI： 10.12452/j.fxcsxb.24020404.

摘要

合成麝香（SMs）是日常洗护用品中广泛使用的香精添加剂，对人体的长期暴露具有潜在健康风险。该研究采用硅胶腕带作为被动采样器采集大学生人群日常接触的SMs，经乙酸乙酯溶液浸提后通过固相萃取（SPE）富集，利用气相色谱-质谱联用技术（GC-MS）和内标法检测个体样品中SMs的暴露浓度，并通过危险商（

）评估SMs暴露的健康风险。结果表明，佳乐麝香（HHCB）和吐纳麝香（AHTN）在5~500 µg/L范围内线性关系良好，相关系数（

）均大于0.999，检出限为1.2~6.6 µg/L，定量下限为4.10~21.9 µg/L。HHCB和AHTN的加标回收率分别为91.6%~113%和92.7%~118%，相对标准偏差（RSD）分别为1.9%~15%和0.81%~11%。在大学生人群中，HHCB和AHTN的每日暴露量分别为2.60 μg/（kg·d）和0.23 μg/（kg·d）。SMs皮肤暴露的危险商（

derm

）小于1，尚不会对大学生群体产生人体健康风险。硅胶腕带可作为化学品人体皮肤暴露的被动采样器，为化学暴露与人体健康风险评估研究提供数据和新方法。

Abstract

Synthetic musks（SMs） are widely utilized as flavor additives in everyday washing，and prolonged exposure to SMs may present potential health risks to humans. This study employs silicone bracelet as passive sampler for the collection of daily exposure to SMs among college students. After extraction with ethyl acetate solution，the samples were concentrated with solid phase extraction（SPE）. The concentration of SMs in individual samples was detected by gas chromatography-mass spectrometry（GC-MS） a

nd internal standard method，while the health risks associated with SMs exposure were assessed by hazard quotient（

）. The findings demonstrate that the galaxolide（HHCB） and tonalide（AHTN） were linear in the range of 5-500 µg/L，with linear correlation coefficients（

） more than 0.999. The limits of detection for the analytes were 1.2-6.6 µg/L and the limits of quantitation were 4.10-21.9 µg/L. The recoveries of HHCB and AHTN ranged from 91.6% to 113% and from 92.7% to 118%，with relative standard deviations（RSDs） ranging from 1.9% to 15% and from 0.81% to 11%，respectively. The average daily exposure to HHCB and AHTN was found to be 2.60 μg/（kg·d） and 0.23 μg/（kg·d），respectively，among the college student population. The

of SMs dermal exposure is below 1，indicating no significant human health risk to the college student population. The study results confirm the silicone bracelet's potential as a new passive sampling device for researching human compound exposure，offering valuable data and research methods for investigating chemical exposure and assessing human health risks.

关键词

硅胶腕带被动采样合成麝香气相色谱-质谱健康风险

Keywords

silicone braceletpassive samplingsynthetic musksgas chromatography-mass spectrometryhealth risks

references

Tumová J，Sauer P，Golovko O，Ucun O K，Grabic R，Máchová J，Kroupová H K. Sci. Total Environ.，2019，651：2235-2246.

Li X X，Gu W W，Chen B，Zhu Z W，Zhang B Y. J. Hazard. Mater.，2021，416：126116.

Lu Y，Yuan T，Wang W H，Kannan K. Environ. Pollut.，2011，159（12）：3522-3528.

Wang T，Zou H Y，Li D Y，Gao J，Bu Q W，Wang Z Y. Environ. Pollut.，2023，331：121893.

Reiner J L，Wong C M，Arcaro K F，Kannan K. Environ. Sci. Technol.，2007，41（11）：3815-3820.

Sousa S，Pestana D，Faria G，Delerue-Matos C，Calhau C，Domingues V F. Sci. Total Environ.，2023：165015.

Luo N，Gao Y P，Chen X Y，Wang M，Niu X L，Li G Y，An T C. Crit. Rev. Environ. Sci. Technol.，2023，53（24）：2132-2149.

Marchal M，Beltran J. Int. J. Environ. Anal. Chem.，2016，96（13）：1213-1246.

Hayward S J，Gouin T，Wania F. Environ. Sci. Technol.，2010，44（9）：3410-3416.

Wania F，Shunthirasingham C. Environ. Sci.-Processes Impacts，2020，22（10）：1925-2002.

Li J R，Chang H E，Zhang N，He Y Z，Zhang D，Liu B S，Fang Y X. Talanta，2023，253：124092.

Manzano C A，Dodder N G，Hoh E，Morales R. Environ. Sci. Technol.，2019，53（2）：614-624.

O'Connell S G，Kincl L D，Anderson K A. Environ. Sci. Technol.，2014，48（6）：3327-3335.

Hammel S C，Phillips A L，Hoffman K，Stapleton H M. Environ. Sci. Technol.，2018，52（20）：11875-11885.

Aerts R，Joly L，Szternfeld P，Tsilikas K，De Cremer K，Castelain P，Aerts J M，Van Orshoven J，Somers B，Hendrickx M，Andjelkovic M，Van Nieuwenhuyse A. Environ. Sci. Technol.，2018，52（1）：298-307.

Wong F N，Robson M，Melymuk L，Shunthirasingham C，Alexandrou N，Shoeib M，Luk E，Helm P，Diamond M L，Hung H. Environ. Sci.-Processes Impacts，2019，21（1）：74-88.

Ding R，Rene E R，Lun X X，Hu Q，Ma W F. Chemosphere，2023，332：138879.

Zhang X L，Yu Y L，Gu Y，Li X J，Zhang X Y，Yu Y X. Chemosphere，2017，173：417-424.

Zhang D P，Zhang X Y，Yu Y X，Li J L，Yu Z Q，Wang D Q，Wu M H，Sheng G Y，Fu J M. Food Chem.，2012，132（2）：975-981.

Wang Z，Liu S Q，Chen X M，Lin C Y. J. Saf. Environ. 王喆，刘少卿，陈晓民，林春野. 安全与环境学报），2008，（4）：152-156.

Christian M S，Parker R M，Hoberman A M，Diener R M，Api A M. Toxicol. Lett.，1999，111（1/2）：169-174.

US EPA. Reference Dose（RfD）：Description and Use in Health Risk Assessments. ［2024-01-30］. https：//www.epa.gov/iris/reference-dose-rfd-description-and-use-health-risk-assessments#1.6.1https://www.epa.gov/iris/reference-dose-rfd-description-and-use-health-risk-assessments#1.6.1.

Ning X J，Zhou J，Fu C Y. China Surfactant Deterg. Cosmet.（宁啸骏，周静，符昌雨. 日用化学工业），2017，47（5）：292-296，300.

Nakata H，Hinosaka M，Yanagimoto H. Ecotoxicol. Environ. Saf.，2015，111：248-255.

Homem V，Silva E，Alves A，Santos L. Chemosphere，2015，139：276-287.

Guo J Y，Zhou Y，Wang Y F，Chen Y，Zhang B Y，Zhang J B. Sci. Total Environ.，2022，845：157379.

Trabalón L，Cano-Sancho G，Pocurull E，Nadal M，Domingo J L，Borrull F. Environ. Res.，2015，143：116-122.

Tseng W J，Tsai S W. Sci. Total Environ.，2019，669：160-167.

Chen W M，Oh J S，Lim J E，Moon H B. Ecotoxicol. Environ. Saf.，2023，266：115538.

Roosens L，Covaci A，Neels H. Chemosphere，2007，69（10）：1540-1547.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Detection of Volatile Organic Compounds in Nail Polish Products Based on Solid-phase Microextraction

Determination of Seven Dimethylcyclosiloxanes in Typical Materials of Intelligent Electronic Products

Identification of Differential Components and Quality Analysis of Blended Flavors and Fragrances Based on Metabolomics Methods

Related Author

OUYANG Wen-yu

LIU Shu-qin

HUANG Ya-xuan

JIANG Rui-fen

XING Yuan-na

PENG Xian-zhi

LENG Yue

HU Yun

Related Institution

School of Environment and Climate，Jinan University

University of Chinese Academy of Sciences

Guangzhou Institute of Geochemistry，Chinese Academy of Sciences

School of Public Health/Key Laboratory of Environmental Pollution Monitoring and Disease Control，Ministry of Education，Guizhou Medical University

Technology Center of China Tobacco Guizhou Industrial Co. Ltd.

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰