Liquid crystal monomers（LCMs） are a group of manmade chemicals used in display devices，while their wide use has caused environmental pollution and health risks. In this study，a simple，sensitive and accurate analytical methodology was established for the determination of LCMs in indoor dust. For the sample pretreatment，dust samples were mixed with stable isotope substituted internal standards（ISs），namely polychlorinated biphenyls（

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C-PCBs） and polybrominated biphenyl ethers（

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C-PBDEs），and then extracted by dichloromethane（DCM），and the supernatant was subsequently transferred to another tube after centrifugation. With anhydrous sodium sulfate adding into the extracted solution，the solution was further purified by a mixture absorbent of primary secondary amine（PSA） and octadecyl-modified silica（C

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）. Finally，37 LCMs were simultaneously tested on a gas chromatography-tandem mass spectrometry performed under dynamic multi-reaction monitoring mode（dMRM），and the internal standards were used for quantification. Instrumental parameters，the use of extraction solvents and absorbents were optimized. Under the best condition，the 37 LCMs exhibited good linearity in the range of 0.1-50 ng/mL，with a method detection limit of 0.02-1.56 ng/g. The average recoveries of the tested substances at two spiking levels was 65.3%-137%，with relative standard deviations（RSDs） of 0.90%-24%. Twenty real indoor dust samples collected in Beijing were tested. The contents of total LCMs in dust ranged from 38.9 to 125 ng/g，and the average contents of the individual LCMs were from 0.044 7 to 25.1 ng/g. Twenty-two LCMs out of the 37 target LCMs presented relatively high detection frequency（higher than 50%），which indicated the ubiquity of LCMs in indoor environment in Beijing. With the spread of smart electronic devices，it is foreseeable that the pollution of LCMs in indoor environment will be rather serious. The analytical method developed in our study presented multiple advantages including simple operation，low solvent consumption，good sensitivity and stability，and it is suitable for large-scale indoor environmental pollution monitoring.