Selective Enrichment and Quantification of α-Asarone in Human Plasma by Dispersive Solid-phase Extraction with Fluorescence Detection

TANG Peng; LIU Tie; LIU De-long

doi:10.12452/j.fxcsxb.23102501

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Selective Enrichment and Quantification of α-Asarone in Human Plasma by Dispersive Solid-phase Extraction with Fluorescence Detection

Scientific Papers | 更新时间：2024-03-13

- Selective Enrichment and Quantification of α-Asarone in Human Plasma by Dispersive Solid-phase Extraction with Fluorescence Detection
- Journal of Instrumental Analysis Vol. 43, Issue 3, Pages: 432-439(2024)
- 作者机构：
  
  1.河北师范大学化学与材料科学学院，河北石家庄 050024
  2.西北师范大学化学化工学院，甘肃兰州 730070
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.23102501
  CLC： O657.3;R457.14
- Published：15 March 2024，
  
  Received：25 October 2023，
  
  Revised：30 November 2023，
- 稿件说明：
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唐芃,刘铁,刘德龙.分散固相萃取/荧光检测法选择性富集和定量人体血浆中的α-细辛醚[J].分析测试学报,2024,43(03):432-439.

TANG Peng,LIU Tie,LIU De-long.Selective Enrichment and Quantification of α-Asarone in Human Plasma by Dispersive Solid-phase Extraction with Fluorescence Detection[J].Journal of Instrumental Analysis,2024,43(03):432-439.
唐芃,刘铁,刘德龙.分散固相萃取/荧光检测法选择性富集和定量人体血浆中的α-细辛醚[J].分析测试学报,2024,43(03):432-439. DOI： 10.12452/j.fxcsxb.23102501.

TANG Peng,LIU Tie,LIU De-long.Selective Enrichment and Quantification of α-Asarone in Human Plasma by Dispersive Solid-phase Extraction with Fluorescence Detection[J].Journal of Instrumental Analysis,2024,43(03):432-439. DOI： 10.12452/j.fxcsxb.23102501.

摘要

该研究采用基于共价有机框架TpBD-Me

（COF-TpBD-Me

）的分散固相萃取/荧光检测法对人体血浆中的α-细辛醚进行选择性富集和定量检测。优化了COF-TpBD-Me

对α-细辛醚的最佳吸附条件，包括吸附剂质量浓度、吸附时间、pH值、解吸试剂和解吸时间。此外，还通过吸附等温线和吸附动力学实验阐明了吸附行为和机理。

-细辛醚在0.1~10 μg/mL范围内呈良好的线性关系，相关系数（

）大于0.999，检出限（LOD）为0.002 5 μg/mL。该方法对人体血浆中

-细辛醚的加标回收率为92.2%~98.0%，相对标准偏差为1.9%~3.8%。实验结果证明所建方法可选择性富集人体血浆中的

-细辛醚并实现准确定量。该方法为选择性富集和快速定量复杂生物基质中的药物活性成分提供了参考。

Abstract

This work used a covalent organic framework TpBD-Me

（COF-TpBD-Me

） based dispersive solid-phase extraction fluorescence detection method to enrich and quantify

-asarone in human plasma. The optimal adsorption conditions of COF-TpBD-Me

on α-asarone were also investigated，including the mass concentration of adsorbent，adsorption time，pH，desorption solvent and desorption time. Furthermore，the adsorption behaviour and mechanism were elucidated by static adsorption and adsorption kinetics studies. α-asarone exhibited a good linear range of 0.1-10 μg/mL，with correlation coefficients（

） greater than 0.999，and the limit of detection（LOD） was 0.002 5 μg/mL. The proposed method applied for the α-asarone in actual human plasma samples for detection recoveries of spiked samples in the range of 92.2%-98.0% with relative standard deviations of 1.9%-3.8%. The results demonstrated that the method can effectively selectively enrich α-asarone in human plasma and accurate quantification. The methodology strategy provided a reference for the selective enrichment and rapid quantification of drug active ingredients in complex biological matrices.

关键词

共价有机框架分散固相萃取吸附α-细辛醚荧光检测

Keywords

covalent organic frameworkdispersive solid-phase extractionadsorptionα-asaronefluorescence detection

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