Analysis and Risk Assessment of Pesticide Residues in <italic style="font-style: italic">Angelica Sinensis</italic> by GC/LC-Q/TOF MS

CHANG Qiao-ying; YANG Zhi-min; BAI Ruo-bin; QIU Guo-yu; LI Jian; ZHU Ren-yuan; ZHANG Hong-yan; YAN Jun; WU Fu-xiang

doi:10.12452/j.fxcsxb.23081404

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Analysis and Risk Assessment of Pesticide Residues in Angelica Sinensis by GC/LC-Q/TOF MS

Scientific Papers | 更新时间：2024-02-21

- Analysis and Risk Assessment of Pesticide Residues in Angelica Sinensis by GC/LC-Q/TOF MS
- Journal of Instrumental Analysis Vol. 43, Issue 2, Pages: 292-300(2024)
- 作者机构：
  
  1.中国检验检疫科学研究院，北京 100176
  2.兰州市食品药品检验检测研究院，食品中农药兽药残留监控重点实验室，甘肃兰州 730050
  3.中原食品实验室，河南漯河 462300
  4.甘肃药业集团科技创新研究院有限公司，甘肃兰州 730050
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.23081404
  CLC： O657.63;R282
- Published：15 February 2024，
  
  Received：14 August 2023，
  
  Revised：10 October 2023，
- 稿件说明：
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常巧英,杨志敏,白若镔等.GC/LC-Q/TOF MS测定当归中农药残留及膳食风险评估[J].分析测试学报,2024,43(02):292-300.

CHANG Qiao-ying,YANG Zhi-min,BAI Ruo-bin,et al.Analysis and Risk Assessment of Pesticide Residues in Angelica Sinensis by GC/LC-Q/TOF MS[J].Journal of Instrumental Analysis,2024,43(02):292-300.
常巧英,杨志敏,白若镔等.GC/LC-Q/TOF MS测定当归中农药残留及膳食风险评估[J].分析测试学报,2024,43(02):292-300. DOI： 10.12452/j.fxcsxb.23081404.

CHANG Qiao-ying,YANG Zhi-min,BAI Ruo-bin,et al.Analysis and Risk Assessment of Pesticide Residues in Angelica Sinensis by GC/LC-Q/TOF MS[J].Journal of Instrumental Analysis,2024,43(02):292-300. DOI： 10.12452/j.fxcsxb.23081404.

摘要

采用气相色谱/液相色谱-四极杆飞行时间质谱（GC/LC-Q/TOF MS）对100例市售当归样品进行了989种农药残留分析，按照风险排序法对检出农药的风险等级进行归类，采用点评估法评估了检出农药的慢性、急性膳食摄入风险，危害指数法（HI）计算了累积风险值。100例当归的总检出率为95%，共检出27种农药，其中甲拌磷和毒死蜱的检出率较高，农药残留量为0.001 0~1.407 7 mg/kg。依据《中国药典（2020年版）》和GB 2763-2021，检出农药中只有甲拌磷、甲基异柳磷、特丁硫磷有最大残留限量（MRL）值，其中甲拌磷的超标率最高。风险排序结果表明，高风险农药为甲拌磷、特丁硫磷、甲基异柳磷。膳食摄入风险和累积风险结果显示，检出农药的慢性膳食摄入风险（%ADI）和急性膳食摄入风险（%ARfD）平均值分别为0.290 8%和0.097 8%，均远低于100%；慢性累积暴露危害指数（HIc）和急性累积暴露危害指数（HIa）分别为0.066 89和0.011 73，均远小于1，慢性和急性膳食摄入风险及累积风险均处于可接受水平。当归中检出农药的膳食摄入和累积暴露的风险均较低，但仍需加强对农药使用的监管，建议制定当归中检出的中等风险农药的MRL值。

Abstract

In this study，a total of 989 pesticide residues were analyzed by gas chromatography and liquid chromatography-time of flight mass spectrometry（GC/LC-Q/TOF MS） in 100 samples of commercially available

Angelica sinensis

，and the risk levels of detected pesticides were categorized according to the risk ranking method of veterinary drug residue matrix，and the chronic and acute dietary intake risk and cumulative risk values of detected pesticides were calculated by point assessment method and hazard index（HI） method，respectively. The total detection rate in 100 cases of

Angelica sinensis

was 95%，and 27 pesticides were detected，among which phorate and chlorpyrifos were detected at a higher rate，with pesticide residue levels ranging from 0.001 0 mg/kg to 1.407 7 mg/kg. According to the Chinese Pharmacopoeia 2020 and GB 2763-2021，only phorate，isofenphos-methyl，and terbufos among the detected pesticides had MRL，of which phorate had the highest exceedance rate. The risk ranking results showed that the high-risk pesticides were phorate，terbufos and isofenphos-methyl. The results of dietary intake risk and cumulative risk showed that the average values of chronic dietary intake risk（%ADI） and acute dietary intake risk（%ARfD） of detected pesticides were 0.290 8% and 0.097 8%，both far below 100%；the chronic cumulative risk（HIc） and acute cumulative exposure（HIa） were 0.066 89 and 0.011 73，respectively，both far less than 1. The chronic and acute dietary intake risk and cumulative risk were both at acceptable levels. The dietary intake and cumulative exposure risks of the pesticides detected in Angelica sinensis were low，but the regulation of pesticide use still needs to be strengthened，and it is recommended to set MRLs for medium risk pesticides detected in

Angelica sinensis

关键词

当归GC-Q/TOF MSLC-Q/TOF MS农药残留风险排序危害指数法风险评估

Keywords

Angelicae sinensisGC-Q/TOF MSLC-Q/TOF MSpesticide residuesrisk rankinghazard indexrisk assessment

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Analysis and Risk Assessment of Pesticide Residues in Angelica Sinensis by GC/LC-Q/TOF MS

DOI：10.12452/j.fxcsxb.23081404

摘要

Abstract

关键词

Keywords

references