A high performance liquid chromatography(HPLC) for quantitative analysis of multi components with a single marker(QAMS) was established for the quality control of Shuganyipi granules.Meanwhile,the applicability and accuracy of the method in quality control were also verified.Three main effective components,i.e.schisandrol,deoxyschisandrin and schisandrin B in Shuganyipi granules were simultaneously separated by HPLC.With schisandrol as the internal reference,the relative correction factors(RCFs) fs/k for other two components were set up and calculated to achieve QAMS.In a certain linear range,the RCFs(fs/k) for deoxyschisandrin and schisandrin B were calculated by multipoint correction method to be 0.94 and 0.95,respectively,with good repeatability under the experimental conditions such as different instruments and chromatographic columns.Moreover,the results of QAMS were compared with those obtained by the external standard method,and there were no significant differences existed.Therefore,the QAMS method is simple,reliable and accurate,and could be used for the simultaneous detection of contents of three components in Shuganyipi granules and the effective control of the quality of Shuganyipi granules.